Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry.

Autor: Lin Y; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France., Jung H; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Bulman CA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94158, United States., Ng J; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France., Vinck R; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France., O'Beirne C; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France., Zhong S; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France., Moser MS; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94158, United States., Tricoche N; Molecular Parasitology, New York Blood Center, Lindsley F. Kimball Research Institute, New York, New York 10065, United States., Peguero R; Molecular Parasitology, New York Blood Center, Lindsley F. Kimball Research Institute, New York, New York 10065, United States., Li RW; United States Department of Agricultural Research Service (USDA-ARS), Animal Parasitic Diseases Laboratory, Beltsville, Maryland 20705, United States., Urban JF Jr; United States Department of Agriculture, Diet, Genomics and Immunology Laboratory, Beltsville, Maryland 20705, United States., Le Pape P; Nantes Université, CHU de Nantes, Cibles et Médicaments des Infections et de l'Immunité, IICiMed, UR 1155, F-44000 Nantes, France., Pagniez F; Nantes Université, CHU de Nantes, Cibles et Médicaments des Infections et de l'Immunité, IICiMed, UR 1155, F-44000 Nantes, France., Moretto M; Fondazione Edmund Mach Via E. Mach 1, Research and Innovation Centre, Via E. Mach 1, 38010 San Michele all'Adige, Italy., Weil T; Fondazione Edmund Mach Via E. Mach 1, Research and Innovation Centre, Via E. Mach 1, 38010 San Michele all'Adige, Italy., Lustigman S; Molecular Parasitology, New York Blood Center, Lindsley F. Kimball Research Institute, New York, New York 10065, United States., Cariou K; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France., Mitreva M; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, United States., Sakanari JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94158, United States., Gasser G; Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Dec 14; Vol. 66 (23), pp. 15867-15882. Date of Electronic Publication: 2023 Nov 27.

In-vitro and in-vivo investigations into the carbene-gold anticancer drug candidates NHC*-Au-SCSNMe2 and NHC*-Au-S-GLUC against advanced prostate cancer PC3.

Autor: Walther W; Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin.; Max Delbrück Center for Molecular Medicine, Berlin, Germany., Althagafi D; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland., Curran D; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland., O'Beirne C; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland., Mc Carthy C; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland., Ott I; Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Braunschweig., Basu U; Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Braunschweig., Büttner B; EPO GmbH Berlin-Buch, Berlin, Germany., Sterner-Kock A; EPO GmbH Berlin-Buch, Berlin, Germany., Müller-Bunz H; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland., Sánchez-Sanz G; Irish Centre of High-End Computing, Grand Canal Quay, Dublin 2, Ireland., Zhu X; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland., Tacke M; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.

Publikováno v: Anti-cancer drugs [Anticancer Drugs] 2020 Aug; Vol. 31 (7), pp. 672-683.

Exposure of Candida parapsilosis to the silver(I) compound SBC3 induces alterations in the proteome and reduced virulence.

Autor: Piatek M; Department of Biology, SSPC Pharma Research Centre, Maynooth University, Maynooth, Co. Kildare, Ireland., O'Beirne C; School of School of Chemistry, University College Dublin, Belfield, Stillorgan, Dublin 4, Ireland., Beato Z; School of School of Chemistry, University College Dublin, Belfield, Stillorgan, Dublin 4, Ireland., Tacke M; School of School of Chemistry, University College Dublin, Belfield, Stillorgan, Dublin 4, Ireland., Kavanagh K; Department of Biology, SSPC Pharma Research Centre, Maynooth University, Maynooth, Co. Kildare, Ireland.

Publikováno v: Metallomics : integrated biometal science [Metallomics] 2022 Aug 03; Vol. 14 (8).

Synthesis, Characterization, and Anticancer Studies of Dimethylene Bridged Bis Tri-n-heterocyclic Carbene Trinuclear Silver(I).

Autor: Abdurrahman, Nuraddeen^1,2, Braim, Farhank Saber^3,4, Razali, Mohd. R.¹ mohd.rizal@usm.my

Publikováno v: Malaysian Journal of Medicine & Health Sciences. 2024 Supplement, Vol. 20, p66-74. 9p.

Antibacterial Activities of Ethanolic and Aqueous Extracts of Vernonia amygdalina (bitter leaf) with Ciprofloxacin on Selected Bacteria.

Autor: Azuamah, Y. C.¹ azuamahyoung@gmail.com, Francis, O. F.¹, Eluchie, E. C.², Johnson, C. F.³

Publikováno v: Nigerian Journal of Parasitology. Sep2024, Vol. 45 Issue 2, p290-298. 9p.