Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Nyssa Drinkwater"'
Autor:
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren J Creek
Publikováno v:
eLife, Vol 13 (2024)
New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of Plasmodium M1 alanyl metalloaminopeptidase as an attractive drug target usin
Externí odkaz:
https://doaj.org/article/332f337244e8411285174e5b2343498f
Autor:
Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum an
Externí odkaz:
https://doaj.org/article/2d940180a1bd41efa98e153bebf7c041
Autor:
Chiara Ruggeri, Nyssa Drinkwater, Komagal Kannan Sivaraman, Rebecca S Bamert, Sheena McGowan, Alessandro Paiardini
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138957 (2015)
The Plasmodium falciparum PfA-M1 and PfA-M17 metalloaminopeptidases are validated drug targets for the discovery of antimalarial agents. In order to identify dual inhibitors of both proteins, we developed a hierarchical virtual screening approach, fo
Externí odkaz:
https://doaj.org/article/1f1c79855b624367819fad8f0ee767bc
Autor:
Alessandro Paiardini, Rebecca S Bamert, Komagal Kannan-Sivaraman, Nyssa Drinkwater, Shailesh N Mistry, Peter J Scammells, Sheena McGowan
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0115859 (2015)
Malaria is a parasitic disease that remains a global health burden. The ability of the parasite to rapidly develop resistance to therapeutics drives an urgent need for the delivery of new drugs. The Medicines for Malaria Venture have compounds known
Externí odkaz:
https://doaj.org/article/126ae061875a4773b3d91cd622d4616e
Autor:
Tess R. Malcolm, Brooke K Hayes, Chaille T. Webb, Nyssa Drinkwater, Karolina Weronika Swiderska, Marcin Drag, Sheena McGowan
Publikováno v:
Biochemical Journal
During malarial infection, Plasmodium parasites digest human hemoglobin to obtain free amino acids for protein production and maintenance of osmotic pressure. The Plasmodium M1 and M17 aminopeptidases are both postulated to have an essential role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc3f4ff2e17b560dabfe69c481086d3
https://doi.org/10.1042/bcj20210172
https://doi.org/10.1042/bcj20210172
Autor:
James Fodor, Blake T. Riley, Kirill Tsyganov, Anne Geert Volbeda, Daniel C. Nelson, Kylie A Farrow, Brooke K. Hayes, Colin J. Jackson, Sheena McGowan, Sebastian S. Broendum, Ben E. Clifton, Ryan D. Heselpoth, Jeroen D. C. Codée, Felix Kraus, Daniel E. Williams, Nyssa Drinkwater, Ashley M. Buckle
Publikováno v:
Molecular Microbiology, 116(2), 397-415. WILEY
Endolysin enzymes from bacteriophage cause bacterial lysis by degrading the peptidoglycan cell wall. The streptococcal C1 phage endolysin PlyC, is the most potent endolysin described to date and can rapidly lyse group A, C, and E streptococci. PlyC i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846e2ef7204d60bb22eabac1ed34cebe
https://doi.org/10.1111/mmi.14719
https://doi.org/10.1111/mmi.14719
Autor:
Emilia M. Marijanovic, Nyssa Drinkwater, Jasmin C Aschenbrenner, James Andersen, Chaille T. Webb, Sheena McGowan, Marcin Drag, Karolina Weronika Swiderska
Publikováno v:
Biochemical Journal
Toxoplasmosis is a parasitic disease caused by infection with Toxoplasma gondii that currently has few therapeutic options. The M1 aminopeptidase enzymes have been shown to be attractive targets for anti-parasitic agents and/or vaccine candidates, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04040875b588f8170d85668035bece7
https://doi.org/10.1042/bcj20200569
https://doi.org/10.1042/bcj20200569
Autor:
Chaille T. Webb, Wei Yang, Blake T. Riley, Brooke K. Hayes, Komagal Kannan Sivaraman, Tess R. Malcolm, Stephen Harrop, Sarah C. Atkinson, Itamar Kass, Ashley M. Buckle, Nyssa Drinkwater, Sheena McGowan
Publikováno v:
The Journal of biological chemistry. 298(7)
The metal-dependent M17 aminopeptidases are conserved throughout all kingdoms of life. This large enzyme family is characterized by a conserved binuclear metal center and a distinctive homohexameric arrangement. Recently, we showed that hexamer forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb66a0f6d0acae1864dd4eadf011c98
https://pubmed.ncbi.nlm.nih.gov/35691342
https://pubmed.ncbi.nlm.nih.gov/35691342
Autor:
Petar P.S. Calic, Natalie B. Vinh, Chaille T. Webb, Tess R. Malcolm, Anna Ngo, Kym Lowes, Nyssa Drinkwater, Sheena McGowan, Peter J. Scammells
Publikováno v:
European Journal of Medicinal Chemistry. 248:115051
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b8e81b37acfeefd0bf2e8efe87ad93b
https://doi.org/10.1016/j.ejmech.2022.115051
https://doi.org/10.1016/j.ejmech.2022.115051
Autor:
Nyssa Drinkwater
The enzyme phenylethanolamine N-methyltransferase (PNMT) catalyses the biosynthesis of adrenaline. Although adrenaline is a significant central nervous system (CNS) neurotransmitter, and has been associated with various physiological processes such a
Externí odkaz:
http://espace.library.uq.edu.au/view/UQ:192678
