Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Nyree Crawford"'
Autor:
Anamarija Jurisic, Pei‐Ju Sung, Mark Wappett, Julien Daubriac, Ian T. Lobb, Wei‐Wei Kung, Nyree Crawford, Natalie Page, Eamon Cassidy, Stephanie Feutren‐Burton, J. S. Shane Rountree, Matthew D. Helm, Colin R. O'Dowd, Richard D. Kennedy, Gerald Gavory, Aaron N. Cranston, Daniel B. Longley, Xavier Jacq, Timothy Harrison
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 4, Pp n/a-n/a (2024)
Abstract Background Understanding how to modulate the microenvironment of tumors that are resistant to immune checkpoint inhibitors represents a major challenge in oncology.Here we investigate the ability of USP7 inhibitors to reprogram the tumor mic
Externí odkaz:
https://doaj.org/article/c9655525645b43019fcffa228b383b32
Autor:
Jerzy A. Woznicki, Nisha Saini, Peter Flood, Subhasree Rajaram, Ciaran M. Lee, Panagiota Stamou, Agnieszka Skowyra, Milan Bustamante-Garrido, Karine Regazzoni, Nyree Crawford, Simon S. McDade, Daniel B. Longley, Pedro Aza-Blanc, Fergus Shanahan, Syed A. Zulquernain, Jane McCarthy, Silvia Melgar, Bradford L. McRae, Ken Nally
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-15 (2021)
Abstract Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes within these networks and both are associated with disrup
Externí odkaz:
https://doaj.org/article/3fd851ad37fa451687518ec09ff3247a
Autor:
Claire Grills, Nyree Crawford, Alex Chacko, Patrick G Johnston, Francesca O'Rourke, Dean A Fennell
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e3038 (2008)
The molecular mechanism underlying mitochondrial BAK activation during apoptosis remains highly controversial. Two seemingly conflicting models have been proposed. In one, BAK requires so-called activating BH3 only proteins (aBH3) to initiate its con
Externí odkaz:
https://doaj.org/article/f0738072c3fe42a8af146655ec5c12b8
Autor:
Daniel B. Longley, Kevin M. Prise, Karl T. Butterworth, Gerard G. Hanna, Timothy Harrison, Patrick G. Johnston, Caitriona Holohan, Nyree Crawford, Catherine Higgins, Joanna Majkut, Catherine Fenning, Izabela Stasik, Luke Humphreys, Conor A. Bradley, Zsuzsanna Nemeth, Kylie A. McLaughlin
Figure legends for Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e283045617eeb7207cfd83637a6fd7
https://doi.org/10.1158/1535-7163.22503607.v1
https://doi.org/10.1158/1535-7163.22503607.v1
Autor:
Simon S. McDade, Ultan McDermott, Daniel B. Longley, Mathew Garnett, Lodewyk Wessels, David A. Tice, Amy Wesa, Ido Sloma, Daniel Ciznadija, Syd Barthorpe, Aikaterini Chatzipli, Vivek Iyer, Magali Michaut, Lewis Gallagher, Jess Bateson, Jamie Young, Jochen Prehn, Katherine McAllister, Christopher McCann, Andrea Lees, Stacey Price, Nyree Crawford, Mark Wappett, Vera Grinkevitch
Multivalent second-generation TRAIL-R2 agonists are currently in late preclinical development and early clinical trials. Herein, we use a representative second-generation agent, MEDI3039, to address two major clinical challenges facing these agents:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2efa1fb2eca5731e15fb0928e1e7b7
https://doi.org/10.1158/1535-7163.c.6543438.v1
https://doi.org/10.1158/1535-7163.c.6543438.v1
Autor:
Daniel B. Longley, Kevin M. Prise, Karl T. Butterworth, Gerard G. Hanna, Timothy Harrison, Patrick G. Johnston, Caitriona Holohan, Nyree Crawford, Catherine Higgins, Joanna Majkut, Catherine Fenning, Izabela Stasik, Luke Humphreys, Conor A. Bradley, Zsuzsanna Nemeth, Kylie A. McLaughlin
Caspase-8 dependent apoptosis induced by IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3b846ebd2384c791188a1352be1b9e
https://doi.org/10.1158/1535-7163.22503616
https://doi.org/10.1158/1535-7163.22503616
Autor:
Simon S. McDade, Ultan McDermott, Daniel B. Longley, Mathew Garnett, Lodewyk Wessels, David A. Tice, Amy Wesa, Ido Sloma, Daniel Ciznadija, Syd Barthorpe, Aikaterini Chatzipli, Vivek Iyer, Magali Michaut, Lewis Gallagher, Jess Bateson, Jamie Young, Jochen Prehn, Katherine McAllister, Christopher McCann, Andrea Lees, Stacey Price, Nyree Crawford, Mark Wappett, Vera Grinkevitch
Supplementary Figure from Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6636bc7fd14949c096b587e72af567
https://doi.org/10.1158/1535-7163.22522569.v1
https://doi.org/10.1158/1535-7163.22522569.v1
Autor:
Daniel B. Longley, Kevin M. Prise, Karl T. Butterworth, Gerard G. Hanna, Timothy Harrison, Patrick G. Johnston, Caitriona Holohan, Nyree Crawford, Catherine Higgins, Joanna Majkut, Catherine Fenning, Izabela Stasik, Luke Humphreys, Conor A. Bradley, Zsuzsanna Nemeth, Kylie A. McLaughlin
IR-induced changes in cell surface expression of death receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03936d5a9db9144762e4bbe9e8602778
https://doi.org/10.1158/1535-7163.22503613.v1
https://doi.org/10.1158/1535-7163.22503613.v1
Autor:
Daniel B. Longley, Kevin M. Prise, Karl T. Butterworth, Gerard G. Hanna, Timothy Harrison, Patrick G. Johnston, Caitriona Holohan, Nyree Crawford, Catherine Higgins, Joanna Majkut, Catherine Fenning, Izabela Stasik, Luke Humphreys, Conor A. Bradley, Zsuzsanna Nemeth, Kylie A. McLaughlin
Response of H460 and A549 cells to IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae4c09e1955ffe2e5fc3184217a8c57
https://doi.org/10.1158/1535-7163.22503619.v1
https://doi.org/10.1158/1535-7163.22503619.v1
Autor:
Simon S. McDade, Ultan McDermott, Daniel B. Longley, Mathew Garnett, Lodewyk Wessels, David A. Tice, Amy Wesa, Ido Sloma, Daniel Ciznadija, Syd Barthorpe, Aikaterini Chatzipli, Vivek Iyer, Magali Michaut, Lewis Gallagher, Jess Bateson, Jamie Young, Jochen Prehn, Katherine McAllister, Christopher McCann, Andrea Lees, Stacey Price, Nyree Crawford, Mark Wappett, Vera Grinkevitch
Supplementary Data from Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65e018c5371d1a9a5d2dd985a27fdf8
https://doi.org/10.1158/1535-7163.22522572.v1
https://doi.org/10.1158/1535-7163.22522572.v1