Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Nyosha Alikhani"'
The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, a major barrier imposed on tumor cells early in tumorigenesis. MYC is a key factor in suppression of RAS/BRAFV600E-induced senescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158e5a702d7d5ef9332cf00610bbd5be
https://doi.org/10.1158/0008-5472.c.6505656
https://doi.org/10.1158/0008-5472.c.6505656
PDF file - 6250K, Activation of BRAFV600E and MYC by Ad-Cre and TAM results in development of SPC-expressing lung tumors. Genomic status after Cre-mediated recombination, MycER protein expression, mouse lung to body weight and expression of different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ecdb9cb666936ac2b42c5dbdde936b
https://doi.org/10.1158/0008-5472.22400748
https://doi.org/10.1158/0008-5472.22400748
PDF file - 152K, Analysis of senescence, apoptosis and p19Arf expression in lung tissues of BRAF/MYC mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90bda0488c8193efc820bee1d0a516b
https://doi.org/10.1158/0008-5472.22400745.v1
https://doi.org/10.1158/0008-5472.22400745.v1
PDF file - 1861K, Lung weights of BRAF/MYC mice early in disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ec9753641aa615aec4111a5019c017
https://doi.org/10.1158/0008-5472.22400742.v1
https://doi.org/10.1158/0008-5472.22400742.v1
Autor:
Zara Zelenko, Ulrich Werner, Norbert Tennagels, Derek LeRoith, Emily J. Gallagher, Jeffrey Blank, Nicholas J. Buffin, Aviva Tobin-Hess, Nyosha Alikhani
Publikováno v:
Diabetes
Endogenous hyperinsulinemia and insulin receptor (IR)/IGF-I receptor (IGF-IR) phosphorylation in tumors are associated with a worse prognosis in women with breast cancer. In vitro, insulin stimulation of the IR increases proliferation of breast cance
Autor:
Nyosha Alikhani, Derek LeRoith, Shoshana Yakar, Rosalyn D. Ferguson, Eyal J. Scheinman, Ruslan Novosyadlyy, Emily J. Gallagher
Publikováno v:
Oncogene. 32:961-967
Dyslipidemia has been associated with an increased risk for developing cancer. However, the implicated mechanisms are largely unknown. To explore the role of dyslipidemia in breast cancer growth and metastasis, we used the apolipoprotein E (ApoE) kno
Autor:
John Xi Chen, Catarina Moreira Pinho, Elzbieta Glaser, Lan Guo, Heng Du, Shirley ShiDu Yan, Shiqiang Yan, Nyosha Alikhani
Publikováno v:
Journal of Alzheimer's Disease. 27:75-87
Accumulation of amyloid-β peptide (Aβ), the neurotoxic peptide implicated in the pathogenesis of Alzheimer's disease (AD), has been shown in brain mitochondria of AD patients and of AD transgenic mouse models. The presence of Aβ in mitochondria le
Autor:
Tanja Engmann, Erika Spånning, Nyosha Alikhani, Elzbieta Glaser, Pavel F. Pavlov, F-Nora Vögtle, Chris Meisinger, Thomas Langer, Anna-Karin Berglund
Publikováno v:
J Mol Biol
Mitochondrial presequences and other unstructured peptides are degraded inside mitochondria by presequence proteases (PrePs) identified in Arabidopsis thaliana (AtPreP), humans (hPreP), and yeast (Cym1/Mop112). The presequences of A. thaliana and hum
Autor:
Elzbieta Glaser, Nyosha Alikhani
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1797(6-7):1076-1080
The novel peptidasome, called presequence protease, PreP, was originally identified and characterized in Arabidopsis thaliana as a mitochondrial matrix and chloroplast stroma localized metalloprotease. PreP has a function as the organellar peptide cl
Autor:
Ville Leinonen, Birgitta Wiehager, Bengt Winblad, Akira Ito, Nyosha Alikhani, Maria Ankarcrona, Pavel F. Pavlov, Camilla A. Hansson Petersen, Irina Alafuzoff, Homira Behbahani, Elzbieta Glaser
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13145-13150
The amyloid β-peptide (Aβ) has been suggested to exert its toxicity intracellularly. Mitochondrial functions can be negatively affected by Aβ and accumulation of Aβ has been detected in mitochondria. Because Aβ is not likely to be produced local