Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nynke M. Kannegieter"'
Autor:
Federica Fabro, Nynke M. Kannegieter, Erik L. de Graaf, Karla Queiroz, Martine L. M. Lamfers, Anna Ressa, Sieger Leenstra
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma is the deadliest brain cancer. One of the main reasons for poor outcome resides in therapy resistance, which adds additional challenges in finding an effective treatment. Small protein kinase inhibitors are molecules that have become wid
Externí odkaz:
https://doaj.org/article/a03d0dd0ba92489c833fc6b7a77ba8fd
pERK-dependent defective TCR-mediated activation of CD4+ T cells in end-stage renal disease patients
Autor:
Ling Huang, Nicolle H. R. Litjens, Nynke M. Kannegieter, Mariska Klepper, Carla C. Baan, Michiel G. H. Betjes
Publikováno v:
Immunity & Ageing, Vol 14, Iss 1, Pp 1-14 (2017)
Abstract Background Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK) and p38, regulate
Externí odkaz:
https://doaj.org/article/7060b6c5185b4bfe94a978062f620a57
Autor:
Nynke M Kannegieter, Dennis A Hesselink, Marjolein Dieterich, Gretchen N de Graav, Rens Kraaijeveld, Carla C Baan
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201113 (2018)
BACKGROUND:Therapeutic drug monitoring (TDM) of tacrolimus, based on blood concentrations, shows an imperfect correlation with the occurrence of rejection. Here, we tested whether measuring NFATc1 amplification, a member of the calcineurin pathway, i
Externí odkaz:
https://doaj.org/article/eb6190b8e98546198065273e514f1eb2
Autor:
Nynke M Kannegieter, Dennis A Hesselink, Marjolein Dieterich, Rens Kraaijeveld, Ajda T Rowshani, Pieter J M Leenen, Carla C Baan
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170806 (2017)
Monocytes and macrophages play key roles in many disease states, including cellular and humoral rejection after solid organ transplantation (SOT). To suppress alloimmunity after SOT, immunosuppressive drug therapy is necessary. However, little is kno
Externí odkaz:
https://doaj.org/article/a3ecb11fa489426b88fb4cee439eb565
Autor:
Lennard J. M. Dekker, Johan M. Kros, Femke Haerkens, Theo M. Luider, Dag Are Steenhoff Hov, Emma Toth, Sieger Leenstra, Lars Verschuren, Julien Fillebeen, Anna Ressa, Nynke M Kannegieter
Publikováno v:
Neuro-oncology Advances
Background Despite maximal therapy with surgery, chemotherapy, and radiotherapy, glioblastoma (GBM) patients have a median survival of only 15 months. Almost all patients inevitably experience symptomatic tumor recurrence. A hallmark of this tumor ty
Autor:
Dennis A. Hesselink, Pieter J. M. Leenen, Ajda T. Rowshani, Gretchen N. de Graav, Carla C. Baan, Rens Kraaijeveld, Marjolein Dieterich, Nynke M. Kannegieter
Publikováno v:
Therapeutic Drug Monitoring, 39(5), 463-471. Lippincott Williams & Wilkins
Background: Monocytes significantly contribute to ischemia-reperfusion injury and allograft rejection after kidney transplantation. However, the knowledge about the effects of immunosuppressive drugs on monocyte activation is limited. Conventional ph
Autor:
Dennis A. Hesselink, Carla C. Baan, Nauras Shuker, Ramin Vafadari, Nynke M. Kannegieter, Willem Weimar
Publikováno v:
Therapeutic Drug Monitoring, 38(2), 280-284. Lippincott Williams & Wilkins
Background: The once-daily formulation of tacrolimus (TACOD) has been developed to overcome adherence problems. Conversion from the twice-daily TAC (TACBID) formulation to TACOD on a 1:1 basis, however, often leads to a decrease of TAC predose concen
Publikováno v:
Transplantation, 100(9), 1833-1839. Lippincott Williams & Wilkins
The profound involvement of cytokines in allograft rejection makes the molecules that control their actions, members of the Jak-Stat pathway, ideal targets for pharmacological intervention. Numerous studies have demonstrated that Jak3 is widely invol
pERK-dependent defective TCR-mediated activation of CD4+ T cells in end-stage renal disease patients
Autor:
Nicolle H.R. Litjens, Nynke M. Kannegieter, Carla C. Baan, Mariska Klepper, Michiel G. H. Betjes, Ling Huang
Publikováno v:
Immunity & Ageing : I & A
Immunity & Ageing, Vol 14, Iss 1, Pp 1-14 (2017)
Immunity and Ageing, 14:14. BioMed Central Ltd.
Immunity & Ageing, Vol 14, Iss 1, Pp 1-14 (2017)
Immunity and Ageing, 14:14. BioMed Central Ltd.
Background Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK) and p38, regulate diverse
Autor:
Marjolein Dieterich, Rens Kraaijeveld, Carla C. Baan, Dennis A. Hesselink, Nynke M. Kannegieter, Gretchen N. de Graav
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, 7:15135. Nature Publishing Group
Scientific Reports
Scientific Reports, 7:15135. Nature Publishing Group
Scientific Reports
Pharmacokinetic immunosuppressive drug monitoring poorly correlates with clinical outcomes after solid organ transplantation. A promising method for pharmacodynamic monitoring of tacrolimus (TAC) in T cell subsets of transplant recipients might be th