Valsartan improves adipose tissue function in humans with impaired glucose metabolism: a randomized placebo-controlled double-blind trial.

Autor: Gijs H Goossens, Chantalle C M Moors, Nynke J van der Zijl, Nicolas Venteclef, Rohia Alili, Johan W E Jocken, Yvonne Essers, Jack P Cleutjens, Karine Clément, Michaela Diamant, Ellen E Blaak

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39930 (2012)

BACKGROUND: Blockade of the renin-angiotensin system (RAS) reduces the incidence of type 2 diabetes mellitus. In rodents, it has been demonstrated that RAS blockade improved adipose tissue (AT) function and glucose homeostasis. However, the effects o

Externí odkaz: https://doaj.org/article/04fd3f0b2ffe44938bb7178e0ac901d3

Pancreatic steatosis in humans: cause or marker of lipotoxicity?

Autor: Michaela Diamant, Daniël H. van Raalte, Nynke J. van der Zijl

Publikováno v: Current Opinion in Clinical Nutrition and Metabolic Care, 13(4), 478-485. Lippincott Williams and Wilkins
van Raalte, D H, van der Zijl, N J & Diamant, M 2010, ' Pancreatic steatosis in humans: cause or marker of lipotoxicity? ', Current Opinion in Clinical Nutrition and Metabolic Care, vol. 13, no. 4, pp. 478-485 . https://doi.org/10.1097/MCO.0b013e32833aa1ef

Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion. Chronically increased levels of plasma nonesterified fatty acids (NEFA) and triglyceride-rich lipoproteins impair beta-cell function, a process referred to as lipotoxicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70eb3f165761d2eed1d2fc98a49ff4b6
https://doi.org/10.1097/mco.0b013e32833aa1ef

Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity

Autor: Mathijs C. Bunck, Nynke J. van der Zijl, Weena J.Y. Chen, Renate E. van Genugten, Erik H. Serné, Anton J.G. Horrevoets, Daniël H. van Raalte, J.M. Baggen, Liselotte van Bloemendaal, Tineke C. T. M. van der Pouw Kraan, Michaela Diamant

Publikováno v: BMC Medical Genomics
van der Pouw-Kraan, T C T M, Chen, J Y, Bunck, M C M, van Raalte, D H, van der Zijl, N J, van Genugten, R E, van Bloemendaal, L, Baggen, J M, Serne, E H, Diamant, M & Horrevoets, A J G 2015, ' Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity ', BMC Medical Genomics, vol. 8, 20 . https://doi.org/10.1186/s12920-015-0096-y
BMC Medical Genomics, 8:20. BioMed Central

Background Metabolic syndrome (MetS) is characterized by central obesity, insulin resistance, dysglycemia, and a pro-atherogenic plasma lipid profile. MetS creates a high risk for development of type 2 diabetes (T2DM) and cardiovascular disease (CVD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123f36ba59af6062da95d4e4d37fbada
https://doi.org/10.1186/s12920-015-0096-y

Valsartan Improves Adipose Tissue Function in Humans with Impaired Glucose Metabolism: A Randomized Placebo-Controlled Double-Blind Trial

Autor: Johan W. E. Jocken, Ellen E. Blaak, Rohia Alili, Karine Clément, Michaela Diamant, Jack P.M. Cleutjens, Nicolas Venteclef, Gijs H. Goossens, Yvonne P. G. Essers, Nynke J. van der Zijl, C.C.M. Moors

Publikováno v: PLoS ONE, 7(6):e39930. Public Library of Science
PLoS ONE, Vol 7, Iss 6, p e39930 (2012)
PLoS ONE
PLoS ONE; Vol 7
Goossens, G H, Moors, C C M, van der Zijl, N J, Venteclef, N, Alili, R, Jocken, J W E, Essers, Y, Cleutjens, J P, Clement, K, Diamant, M & Blaak, E E 2012, ' Valsartan Improves Adipose Tissue Function in Humans with Impaired Glucose Metabolism: A Randomized Placebo-Controlled Double-Blind Trial ', PLoS ONE, vol. 7, no. 6, e39930 . https://doi.org/10.1371/journal.pone.0039930
PLOS ONE, 7(6):39930. Public Library of Science

Background Blockade of the renin-angiotensin system (RAS) reduces the incidence of type 2 diabetes mellitus. In rodents, it has been demonstrated that RAS blockade improved adipose tissue (AT) function and glucose homeostasis. However, the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc0d70aeb564f35ea2e85b0b76507a7
https://research.vumc.nl/en/publications/315a2bda-defb-4e5e-bb7c-fc4330029a21

C-reactive protein mediates the association of liver fat and carotid intima–media thickness in healthy men and men with the metabolic syndrome and/or uncomplicated type 2 diabetes

Autor: Ellen E. Blaak, C.C.M. Moors, Marcel H.A. Muskiet, Maarten E. Tushuizen, Luuk-Jon Rijzewijk, Nynke J. van der Zijl, Michaela Diamant, Gijs H. Goossens, Petra J. W. Pouwels, Roger K. Schindhelm

Publikováno v: van der Zijl, N J, Muskiet, M H A, Tushuizen, M E, Rijzewijk, L J, Schindhelm, R K, Moors, C C M, Goossens, G H, Blaak, E E, Pouwels, P J W & Diamant, M 2010, ' C-reactive protein mediates the association of liver fat and carotid intima–media thickness in healthy men and men with the metabolic syndrome and/or uncomplicated type 2 diabetes ', Diabetes Metabolic Syndromes, vol. 4, pp. 160-164 . https://doi.org/10.1016/j.dsx.2010.05.018
Diabetes Metabolic Syndromes, 4, 160-164. Dove Medical Press Ltd.
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 4(3), 160-164. Elsevier BV

We investigated whether the relation between liver fat and subclinical atherosclerosis is mediated by low-grade systemic inflammation in type 2 diabetes (T2DM) and the metabolic syndrome (MetS). In 16 T2DM, 36 MetS, and 21 age-matched healthy men, li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdba526fe7a819228aa8f6f84372c042
https://research.vumc.nl/ws/files/705776/257591.pdf