High Sensitivity of BRCA1-Deficient Mammary Tumors to the PARP Inhibitor AZD2281 Alone and in Combination with Platinum Drugs

Autor: Rottenberg, Sven, Jaspers, Janneke E., Kersbergen, Ariena, van der Burg, Eline, Nygren, Anders O. H., Zander, Serge A. L., Derksen, Patrick W. B., de Bruin, Michiel, Zevenhoven, John, Lau, Alan, Boulter, Robert, Cranston, Aaron, O'Connor, Mark J., Martin, Niall M. B., Borst, Piet, Jonkers, Jos

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2008 Nov 01. 105(44), 17079-17084.

Externí odkaz: https://www.jstor.org/stable/25465228

Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia

Autor: Newton, Timothy, Allison, Rachel, Schüle, Rebecca, Depienne, Christel, Goldberg, Lisa, Frahm, Christiane, Stevanin, Giovanni, Durr, Alexandra, Schöls, Ludger, Winner, Beate, Beetz, Christian, Reid, Evan, Edgar, James R, Lumb, Jennifer H, Rodger, Catherine E, Manna, Paul T, Rizo, Tania, Kohl, Zacharias, Nygren, Anders O H, Arning, Larissa

Publikováno v: Brain
Brain 141(5), 1286-1299 (2018). doi:10.1093/brain/awy034

The mechanisms underlying disease modifier gene effects are rarely understood. Newton et al. report that deletion of DPY30 reduces age at onset in hereditary spastic paraplegia caused by SPAST mutations. They demonstrate that both genes regulate cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2f58674556c2f1343945f1db8f441f
https://pubmed.ncbi.nlm.nih.gov/29481671

Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

Autor: Bock, Christoph, Halbritter, Florian, Carmona, Francisco J., Tierling, Sascha, Datlinger, Paul, Assenov, Yassen, Berdasco, María, Bergmann, Anke K., Booher, Keith, Busato, Florence, Campan, Mihaela, Dahl, Christina, Dahmcke, Christina M., Diep, Dinh, Fernández, Agustín F., Gerhauser, Clarissa, Haake, Andrea, Heilmann, Katharina, Holcomb, Thomas, Hussmann, Dianna, Ito, Mitsuteru, Kläver, Ruth, Kreutz, Martin, Kulis, Marta, López, Virginia, Nair, Shalima S., Paul, Dirk S., Plongthongkum, Nongluk, Qu, Wenjia, Queirós, Ana C., Reinicke, Frank, Sauter, Guido, Schlomm, Thorsten, Statham, Aaron, Stirzaker, Clare, Strogantsev, Ruslan, Urdinguio, Rocío G., Walter, Kimberly, Weichenhan, Dieter, Weisenberger, Daniel J., Beck, Stephan, Clark, Susan J., Esteller, Manel, Ferguson-Smith, Anne C., Fraga, Mario F., Guldberg, Per, Lotte Hansen, Lise, Laird, Peter W., Martín, José Ignacio, Nygren, Anders O. H., Peist, Ralf, Plass, Christoph, Shames, David S., Siebert, Reiner, Sun, Xueguang, Tost, Jörg, Walter, Jörn, Zhang, Kun

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Bock, C; Halbritter, F; Carmona, FJ; Tierling, S; Datlinger, P; Assenov, Y; et al.(2016). Quantitative comparison of DNA methylation assays for biomarker development and clinical applications. Nature Biotechnology, 34(7), 726-737. doi: 10.1038/nbt.3605. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7tf2342w
Digital.CSIC. Repositorio Institucional del CSIC
Bock, C, Halbritter, F, Carmona, F J, Tierling, S, Datlinger, P, Assenov, Y, Berdasco, M, Bergmann, A K, Booher, K, Busato, F, Campan, M, Dahl, C, Dahmcke, C M, Diep, D, Fernández, A F, Gerhauser, C, Haake, A, Heilmann, K, Holcomb, T, Hussmann, D, Ito, M, Kläver, R, Kreutz, M, Kulis, M, Lopez, V, Nair, S S, Paul, D S, Plongthongkum, N, Qu, W, Queirós, A C, Reinicke, F, Sauter, G, Schlomm, T, Statham, A, Stirzaker, C, Strogantsev, R, Urdinguio, R G, Walter, K, Weichenhan, D, Weisenberger, D J, Beck, S, Clark, S J, Esteller, M, Ferguson-Smith, A C, Fraga, M F, Guldberg, P, Hansen, L L, Laird, P W, Martín-Subero, J I, Nygren, A O H, Peist, R, Plass, C, Shames, D S, Siebert, R, Sun, X, Tost, J, Walter, J & Zhang, K 2016, ' Quantitative comparison of DNA methylation assays for biomarker development and clinical applications ', Nature Biotechnology, vol. 34, no. 7, pp. 726-737 . https://doi.org/10.1038/nbt.3605

The BLUEPRINT consortium
DNA methylation patterns are altered in numerous diseases and often correlate with clinically relevant information such as disease subtypes, prognosis and drug response. With suitable assays and after validation in large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affe02728fa269d7dd6cad500339a45e
https://pubmed.ncbi.nlm.nih.gov/27347756

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