Separating Putative Pathogens from Background Contamination with Principal Orthogonal Decomposition: Evidence for Leptospira in the Ugandan Neonatal Septisome

Autor: Schiff, Steven J., Kiwanuka, Julius, Riggio, Gina, Nguyen, Lan, Mu, Kevin, Sproul, Emily, Bazira, Joel, Mwanga, Juliet, Tumusiime, Dickson, Nyesigire, Eunice, Lwanga, Nkangi, Bogale, Kaleb T., Kapur, Vivek, Broach, James, Morton, Sarah, Warf, Benjamin C., Poss, Mary

Neonatal sepsis (NS) is responsible for over a 1 million yearly deaths worldwide. In the developing world NS is often treated without an identified microbial pathogen. Amplicon sequencing of the bacterial 16S rRNA gene can be used to identify organis

Externí odkaz: http://arxiv.org/abs/1602.00600

Separating Putative Pathogens from Background Contamination with Principal Orthogonal Decomposition: Evidence for Leptospira in the Ugandan Neonatal Septisome.

Autor: Schiff SJ; Center for Neural Engineering, Pennsylvania State University, University Park, PA, USA; Department of Neurosurgery, Penn State College of Medicine, Hershey, PA, USA; Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA, USA; Department of Physics, Pennsylvania State University, University Park, PA, USA., Kiwanuka J; Department of Pediatrics, Mbarara University of Science and Technology , Mbarara , Uganda., Riggio G; Department of Biology, Pennsylvania State University, University Park, PA, USA; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA., Nguyen L; Department of Biology, Pennsylvania State University, University Park, PA, USA; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA; Department of Biochemistry and Molecular Biology, Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA., Mu K; Department of Biology, Pennsylvania State University, University Park, PA, USA; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA., Sproul E; Department of Biology, Pennsylvania State University, University Park, PA, USA; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA., Bazira J; Department of Microbiology, Mbarara University of Science and Technology , Mbarara , Uganda., Mwanga-Amumpaire J; Department of Pediatrics, Mbarara University of Science and Technology, Mbarara, Uganda; Epicentre Mbarara Research Centre, Mbarara, Uganda., Tumusiime D; Department of Pediatrics, Mbarara University of Science and Technology , Mbarara , Uganda., Nyesigire E; Department of Pediatrics, Mbarara University of Science and Technology , Mbarara , Uganda., Lwanga N; Department of Microbiology, Mbarara University of Science and Technology , Mbarara , Uganda., Bogale KT; Center for Neural Engineering, Pennsylvania State University, University Park, PA, USA; Schreyer's Honors College, Pennsylvania State University, University Park, PA, USA., Kapur V; Department of Veterinary and Biomedical Sciences, Pennsylvania State University , University Park, PA , USA., Broach JR; Department of Biochemistry and Molecular Biology, Institute for Personalized Medicine, Pennsylvania State University College of Medicine , Hershey, PA , USA., Morton SU; Center for Neural Engineering, Pennsylvania State University, University Park, PA, USA; Harvard Neonatal-Perinatal Training Program, Children's Hospital Boston, Boston, MA, USA., Warf BC; Department of Neurosurgery, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA; Department of Global Health and Social Medicine, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA; CURE Children's Hospital of Uganda, Mbale, Uganda., Poss M; Department of Biology, Pennsylvania State University, University Park, PA, USA; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA.

Publikováno v: Frontiers in medicine [Front Med (Lausanne)] 2016 Jun 13; Vol. 3, pp. 22. Date of Electronic Publication: 2016 Jun 13 (Print Publication: 2016).