Impact of CCR5Δ32 on the risk of infection, Staphylococcus aureus carriage, and plasma concentrations of chemokines in Danish blood donorsResearch in context

Autor: Khoa Manh Dinh, Kathrine Agergård Kaspersen, Susan Mikkelsen, Bertram Dalskov Kjerulff, Jens Kjærgaard Boldsen, Mikkel Steen Petersen, Kristoffer Sølvsten Burgdorf, Erik Sørensen, Bitten Aagaard, Barbara Forman-Ankjær, Mie Topholm Bruun, Karina Banasik, Thomas Folkmann Hansen, Mette Nyegaard, Palle Duun Rohde, Søren Brunak, Henrik Hjalgrim, Sisse Rye Ostrowski, Ole Birger Pedersen, Henrik Ullum, Lise Tornvig Erikstrup, Christian Erikstrup

Publikováno v: EBioMedicine, Vol 109, Iss , Pp 105406- (2024)

Summary: Background: The CC chemokine receptor 5 (CCR5) is a suggested receptor for Staphylococcus aureus leukotoxin ED. Homozygosity for the Δ32 deletion (CCR5Δ32) protects against human immunodeficiency virus infection and possibly also against l

Externí odkaz: https://doaj.org/article/496f17474dfa4c9eaaea2553dc828310

Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

Autor: Bertram Kjerulff, Joseph Dowsett, Rikke Louise Jacobsen, Josephine Gladov, Margit Hørup Larsen, Agnete Troen Lundgaard, Karina Banasik, David Westergaard, Susan Mikkelsen, Khoa Manh Dinh, Lotte Hindhede, Kathrine Agergård Kaspersen, Michael Schwinn, Anders Juul, Betina Poulsen, Birgitte Lindegaard, Carsten Bøcker Pedersen, Clive Eric Sabel, Henning Bundgaard, Henriette Svarre Nielsen, Janne Amstrup Møller, Jens Kjærgaard Boldsen, Kristoffer Sølvsten Burgdorf, Lars Vedel Kessing, Linda Jenny Handgaard, Lise Wegner Thørner, Maria Didriksen, Mette Nyegaard, Niels Grarup, Niels Ødum, Pär I. Johansson, Poul Jennum, Ruth Frikke-Schmidt, Sanne Schou Berger, Søren Brunak, Søren Jacobsen, Thomas Folkmann Hansen, Tine Kirkeskov Lundquist, Torben Hansen, Torben Lykke Sørensen, Torben Sigsgaard, Kaspar René Nielsen, Mie Topholm Bruun, Henrik Hjalgrim, Henrik Ullum, Klaus Rostgaard, Erik Sørensen, Ole Birger Pedersen, Sisse Rye Ostrowski, Christian Erikstrup

Publikováno v: Communications Medicine, Vol 4, Iss 1, Pp 1-15 (2024)

Abstract Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy in

Externí odkaz: https://doaj.org/article/2cf9df2a8b374f6abb5d546a3f0b5949

From polycrisis to metacrisis: harnessing windows of opportunity for renewed political leadership in global health diplomacy

Autor: Walaiporn Patcharanarumol, Amirhossein Takian, Rebecca Katz, Peter Piot, Ilona Kickbusch, Hampus Holmer, Rajat Khosla, John-Arne Røttingen, Suerie Moon, Fadi El-Jardali, Tobias Alfvén, Ellen Rosskam, Brian Li Han Wong, Joanne Liu, Helen Clark, Rahul M Jindal, Heidi Larson, Anders Nordström, Warisa Panichkriangkrai, Michel Kazatchkine, Salma Abdalla, Maria Guevara, Björn Kümmel, Rhoda Wanyenze, Garry Aslanyan, Ahmed Al Mandhari, Lyndsay Baines, Adebe Bekele, Gunilla Carlsson, Rooney Long Hei Fong, Emi Inaoka, Mike Kalmus-Eliasz, Minah Kang, Jerome Kim, Jimmy Kolker, Lwazi Manzi, Ren Minghui, Susan Mochache, Morten Nyegaard, Sanjay M Pattanshetty, Carita Rehn, Paul Rosenbaum, Gustaf Salford, Ahn Wartel, Karl Wennberg, Josefin Wiklund

Publikováno v: BMJ Global Health, Vol 9, Iss 4 (2024)

Externí odkaz: https://doaj.org/article/61a83026a4c5420280fe0d9674857673

Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality

Autor: Asmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny A. Arnadottir, Valgerdur Steinthorsdottir, Gisli H. Halldorsson, Bjarni A. Atlason, Gudjon R. Oskarsson, Hannes Helgason, Henriette Svarre Nielsen, David Westergaard, Juha M. Karjalainen, Hildigunnur Katrinardottir, Run Fridriksdottir, Brynjar O. Jensson, Vinicius Tragante, Egil Ferkingstad, Hakon Jonsson, Sigurjon A. Gudjonsson, Doruk Beyter, Kristjan H. S. Moore, Helga B. Thordardottir, Snaedis Kristmundsdottir, Olafur A. Stefansson, Solbritt Rantapää-Dahlqvist, Ida Elken Sonderby, Maria Didriksen, Pernilla Stridh, Jan Haavik, Laufey Tryggvadottir, Oleksandr Frei, G. Bragi Walters, Ingrid Kockum, Henrik Hjalgrim, Thorunn A. Olafsdottir, Geir Selbaek, Mette Nyegaard, Christian Erikstrup, Thorsten Brodersen, Saedis Saevarsdottir, Tomas Olsson, Kaspar Rene Nielsen, Asgeir Haraldsson, Mie Topholm Bruun, Thomas Folkmann Hansen, DBDS Genomic Consortium, Thora Steingrimsdottir, Rikke Louise Jacobsen, Rolv T. Lie, Srdjan Djurovic, Lars Alfredsson, Aitzkoa Lopez de Lapuente Portilla, Soren Brunak, Pall Melsted, Bjarni V. Halldorsson, Jona Saemundsdottir, Olafur Th. Magnusson, Leonid Padyukov, Karina Banasik, Thorunn Rafnar, Johan Askling, Lars Klareskog, Ole Birger Pedersen, Gisli Masson, Alexandra Havdahl, Bjorn Nilsson, Ole A. Andreassen, Mark Daly, Sisse Rye Ostrowski, Ingileif Jonsdottir, Hreinn Stefansson, Hilma Holm, Agnar Helgason, Unnur Thorsteinsdottir, Kari Stefansson, Daniel F. Gudbjartsson

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with deficit of homozygos

Externí odkaz: https://doaj.org/article/a4fa595277a74ef2949c5d74d9c4032d

Children and adolescents with attention deficit hyperactivity disorder and autism spectrum disorder share distinct microbiota compositions

Autor: Caspar Bundgaard-Nielsen, Marlene Briciet Lauritsen, Julie Kristine Knudsen, Louise Søndergaard Rold, Margit Hørup Larsen, Peter Hindersson, Annemarie Brusen Villadsen, Peter D. C. Leutscher, Søren Hagstrøm, Mette Nyegaard, Suzette Sørensen

Publikováno v: Gut Microbes, Vol 15, Iss 1 (2023)

ABSTRACTAn association has been suggested between altered gut microbiota, and attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD), respectively. Thus, we analyzed the gut microbiota composition in children and adolesce

Externí odkaz: https://doaj.org/article/85b2367d06a14019a705d7d06bdb163c