Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nydia Tejeda-Munoz"'
Autor:
Nydia Tejeda-Munoz, Yagmur Azbazdar, Julia Monka, Grace Binder, Alex Dayrit, Raul Ayala, Neil O'Brien, Edward M De Robertis
Publikováno v:
eLife, Vol 12 (2023)
Activation of the Wnt pathway lies at the core of many human cancers. Wnt and macropinocytosis are often active in the same processes, and understanding how Wnt signaling and membrane trafficking cooperate should improve our understanding of embryoni
Externí odkaz:
https://doaj.org/article/c050ab64f51242de82c4d3fd42c3621a
Autor:
Yagmur Azbazdar, Nydia Tejeda-Munoz, Julia C. Monka, Alex Dayrit, Grace Binder, Gunes Ozhan, Edward M. De Robertis
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108075- (2023)
Summary: Activation of Wnt signaling triggers macropinocytosis and drives many tumors. We now report that the exogenous addition of the second messenger lipid sn-1,2 DAG to the culture medium rapidly induces macropinocytosis. This is accompanied by p
Externí odkaz:
https://doaj.org/article/e2b67310fbdd4d52b43b54a2b772dc95
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32243- (2024)
The Wnt signaling pathway is one of the most ancient and pivotal signaling cascades, governing diverse processes in development and cancer regulation. Within the realm of cancer treatment, genistein emerges as a promising candidate due to its multifa
Externí odkaz:
https://doaj.org/article/99839d4767e845a99666c3dd7be45bae
Autor:
Nydia Tejeda-Muñoz, Yagmur Azbazdar, Eric A. Sosa, Julia Monka, Pu-Sheng Wei, Grace Binder, Kuo-Ching Mei, Yerbol Z. Kurmangaliyev, Edward M. De Robertis
Publikováno v:
Biology Open, Vol 13, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/8209293db1834421b783329a357b4e1a
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101455- (2022)
Summary: The Xenopus embryo provides an advantageous model system where genes can be readily transplanted as DNA or mRNA or depleted with antisense techniques. Here, we present a protocol to culture and image the cell biological properties of explant
Externí odkaz:
https://doaj.org/article/74cf5304b1b644ab8073ece6bb6bc03a
Autor:
Gabriele Colozza, Yasaman Jami-Alahmadi, Alyssa Dsouza, Nydia Tejeda-Muñoz, Lauren V. Albrecht, Eric A. Sosa, James A. Wohlschlegel, Edward M. De Robertis
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract The canonical Wnt pathway serves as a hub connecting diverse cellular processes, including β-catenin signaling, differentiation, growth, protein stability, macropinocytosis, and nutrient acquisition in lysosomes. We have proposed that seque
Externí odkaz:
https://doaj.org/article/70bc8e647cea4e6a97568c3d15403f70
Autor:
Nydia Tejeda-Muñoz, Marco Morselli, Yuki Moriyama, Pooja Sheladiya, Matteo Pellegrini, Edward M. De Robertis
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104123- (2022)
Summary: During canonical Wnt signaling, the Wnt receptor complex is sequestered together with glycogen synthase kinase 3 (GSK3) and Axin inside late endosomes, known as multivesicular bodies (MVBs). Here, we present experiments showing that Wnt caus
Externí odkaz:
https://doaj.org/article/cbfd10f4bdd549a2aabbfdfecb58b5b7
Publikováno v:
Vaccines, Vol 10, Iss 5, p 790 (2022)
Membrane trafficking is emerging as an attractive therapeutic strategy for cancer. Recent reports have found a connection between Wnt signaling, receptor-mediated endocytosis, V-ATPase, lysosomal activity, and macropinocytosis through the canonical W
Externí odkaz:
https://doaj.org/article/d15f1d48bef94be386d58c8271e4a6b3
Autor:
Lauren V. Albrecht, Nydia Tejeda-Muñoz, Maggie H. Bui, Andrew C. Cicchetto, Daniele Di Biagio, Gabriele Colozza, Ernst Schmid, Stefano Piccolo, Heather R. Christofk, Edward M. De Robertis
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107973- (2020)
Summary: Canonical Wnt signaling is emerging as a major regulator of endocytosis. Here, we report that Wnt-induced macropinocytosis is regulated through glycogen synthase kinase 3 (GSK3) and the β-catenin destruction complex. We find that mutation o
Externí odkaz:
https://doaj.org/article/755ba4acfcda4998a5b3697ba8f76315