The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence.

Autor: Laure N A Ries, Lakhansing Pardeshi, Zhiqiang Dong, Kaeling Tan, Jacob L Steenwyk, Ana Cristina Colabardini, Jaire A Ferreira Filho, Patricia A de Castro, Lilian P Silva, Nycolas W Preite, Fausto Almeida, Leandro J de Assis, Renato A C Dos Santos, Paul Bowyer, Michael Bromley, Rebecca A Owens, Sean Doyle, Marilene Demasi, Diego C R Hernández, Luís Eduardo S Netto, Monica T Pupo, Antonis Rokas, Flavio V Loures, Koon H Wong, Gustavo H Goldman

Publikováno v: PLoS Pathogens, Vol 16, Iss 7, p e1008645 (2020)

Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT)

Externí odkaz: https://doaj.org/article/a8f50cb4322d4e79bd71b302c6284ecd

The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence

Autor: Zhiqiang Dong, Nycolas W. Preite, Leandro José de Assis, Paul Bowyer, Diego C. R. Hernández, Mônica Tallarico Pupo, Kaeling Tan, Rebecca A. Owens, Laure Nicolas Annick Ries, Jaire Alves Ferreira Filho, Koon Ho Wong, Lilian Pereira Silva, Gustavo H. Goldman, Patrícia Alves de Castro, Jacob L. Steenwyk, Fausto Almeida, Michael Bromley, Renato Augusto Corrêa dos Santos, Sean Doyle, Marilene Demasi, Luis Eduardo Soares Netto, Ana Cristina Colabardini, Flávio V. Loures, Lakhansing Pardeshi, Antonis Rokas

Publikováno v: PLoS Pathogens
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Pathogens, Vol 16, Iss 7, p e1008645 (2020)
Ries, L N A, Pardeshi, L, Dong, Z, Tan, K, Steenwyk, J L, Colabardini, A C, Ferreira Filho, J A, Castro, P A D, Silva, L P, Preite, N W, Almeida, F, Assis, L J D, Santos, R A C D, Bowyer, P, Bromley, M, Owens, R A, Doyle, S, Demasi, M, Hemandez, D C R, Netto, L E S, Pupo, M T, Rokas, A, Loures, F V, Wong, K H & Goldman, G H 2020, ' The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence ', PL o S Pathogens . https://doi.org/10.1371/journal.ppat.1008645

Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263fa382ae2544b3f4f568df5da3fcdf
https://pubmed.ncbi.nlm.nih.gov/32667960

Depletion of regulatory T cells in ongoing paracoccidioidomycosis rescues protective Th1/Th17 immunity and prevents fatal disease outcome

Autor: Eliseu Frank de Araújo, Flávio V. Loures, Nayane Alves de Lima Galdino, Tania Alves da Costa, Vera Lúcia Garcia Calich, Nycolas W. Preite

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports

In human paracoccidioidomycosis (PCM), a primary fungal infection typically diagnosed when the disease is already established, regulatory T cells (Treg) cells are associated with disease severity. Experimental studies in pulmonary PCM confirmed the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8849b866ec1cba448866bf8f463940
https://doi.org/10.1038/s41598-018-35037-8

The IDO-AhR axis controls Th17/Treg immunity in a pulmonary model of fungal infection

Autor: Flávio V. Loures, Eliseu Frank de Araújo, Vera Lúcia Garcia Calich, Claudia Feriotti, Nycolas W. Preite, Nayane Alves de Lima Galdino

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)

In infectious diseases, the enzyme indoleamine 2,3 dioxygenase-1 (IDO1) that catalyzes the tryptophan (Trp) degradation along the kynurenines (Kyn) pathway has two main functions, the control of pathogen growth by reducing available Trp and immune re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b286e686fc296f9aafc882dfcec6200c