Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nyanza J Rothman"'
Autor:
Senem Aykul, Richard A Corpina, Erich J Goebel, Camille J Cunanan, Alexandra Dimitriou, Hyon Jong Kim, Qian Zhang, Ashique Rafique, Raymond Leidich, Xin Wang, Joyce McClain, Johanna Jimenez, Kalyan C Nannuru, Nyanza J Rothman, John B Lees-Shepard, Erik Martinez-Hackert, Andrew J Murphy, Thomas B Thompson, Aris N Economides, Vincent Idone
Publikováno v:
eLife, Vol 9 (2020)
Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC). Although the former property has been studied extensively, the roles of the NSC remain unex
Externí odkaz:
https://doaj.org/article/f046d1441e0d4e23a1f1b1baf6223516
Autor:
William C. Adams, Yen-Hua Chen, Radomir Kratchmarov, Bonnie Yen, Simone A. Nish, Wen-Hsuan W. Lin, Nyanza J. Rothman, Larry L. Luchsinger, Ulf Klein, Meinrad Busslinger, Jeffrey C. Rathmell, Hans-Willem Snoeck, Steven L. Reiner
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3142-3152 (2016)
Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial clearance impacts cell fate and reflects larger constellations of op
Externí odkaz:
https://doaj.org/article/5bde382393f64c32b1a85536f31cbaa6
Autor:
Konstantinos Panitsas, Mishaela R. Rubin, Nyanza J. Rothman, Stavroula Kousteni, Steven Shikhel, Roxane Tenta, Brygida Bisikirska, Ioanna Mosialou, Cyrille B. Confavreux, Thomas L. Nickolas, Na Luo, Bertrand Cariou, Elisabeth Sornay-Rendu, Peristera-Ioanna Petropoulou, Matthieu Wargny
Publikováno v:
The Journal of Experimental Medicine
LCN2 is an osteoblast-enriched secreted protein that regulates food intake. Here, the authors show that LCN2 is upregulated during obesity and diabetes as a protective mechanism to counteract obesity-induced glucose intolerance by decreasing food int
Autor:
Xin Wang, Vincent Idone, Senem Aykul, Alexandra Dimitriou, Richard A. Corpina, Nyanza J Rothman, Erich J Goebel, Qian Zhang, Thomas B. Thompson, Camille J Cunanan, Raymond W. Leidich, Hyon Jong Kim, Joyce McClain, Ashique Rafique, John B Lees-Shepard, Andrew J. Murphy, Aris N. Economides, Johanna Jimenez, Kalyan C. Nannuru, Erik Martinez-Hackert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2247d27f0cbb68bbe73d1d0b93dc257
https://doi.org/10.7554/elife.54582.sa2
https://doi.org/10.7554/elife.54582.sa2
Autor:
Radomir Kratchmarov, Sara Viragova, Steven L. Reiner, Nyanza J. Rothman, Kang Liu, Boris Reizis, Min Jung Kim
Publikováno v:
Immunology and Cell Biology. 96:863-871
Growth signals drive hematopoietic progenitor cells to proliferate and branch into divergent cell fates, but how unequal outcomes arise from a common progenitor is not fully understood. We used steady-state analysis of in vivo hematopoiesis and Fms-r
Autor:
Yen-Hua Chen, Nyanza J. Rothman, Bonnie Yen, Wen-Hsuan W. Lin, Radomir Kratchmarov, William C. Adams, Simone A. Nish, Steven L. Reiner, Jeffrey C. Rathmell
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 860-868 (2018)
Cell reports
Cell reports
SUMMARY Unequal transmission of nutritive signaling during cell division establishes fate disparity between sibling lymphocytes, but how asymmetric signaling becomes organized is not understood. We show that receptor-associated class I phosphatidylin
Autor:
Nyanza J. Rothman, Ulf Klein, Wen-Hsuan W. Lin, Radomir Kratchmarov, Simone A. Nish, Bonnie Yen, William C. Adams, Steven L. Reiner, Yen-Hua Chen
Publikováno v:
ImmunoHorizons. 1:156-161
Anabolic metabolism in lymphocytes promotes plasmablast and cytotoxic T cell differentiation at the expense of self-renewal. Heightened expression and function of the transcription factor IFN regulatory factor 4 (IRF4) accompany enhanced anabolic ind
Autor:
Kyra D. Zens, William C. Adams, Nyanza J. Rothman, Wen-Hsuan W. Lin, Yen-Hua Chen, Radomir Kratchmarov, Bonnie Yen, Simone A. Nish, Avinash Bhandoola, Steven L. Reiner, Hai-Hui Xue, Donna L. Farber
Publikováno v:
The Journal of Experimental Medicine
Nish et al. report that production of a fully committed Th1 effector cell occurs during an asymmetric cell division wherein the other daughter cell remains memory cell–like. Unequal transmission of metabolic signaling may be the driver of this rege
Autor:
Ulf Klein, Bonnie Yen, Larry L. Luchsinger, Steven L. Reiner, Yen-Hua Chen, Jeffrey C. Rathmell, Hans-Willem Snoeck, Nyanza J. Rothman, Meinrad Busslinger, Simone A. Nish, William C. Adams, Wen-Hsuan W. Lin, Radomir Kratchmarov
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3142-3152 (2016)
Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial clearance impacts cell fate and reflects larger constellations of op
Autor:
William C. Adams, Simone A. Nish, Hai-Hui Xue, Yen-Hua Chen, Avinash Bhandoola, Wen-Hsuan W. Lin, Steven L. Reiner, Radomir Kratchmarov, Bonnie Yen, Nyanza J. Rothman
Publikováno v:
Cell Reports, Vol 17, Iss 7, Pp 1773-1782 (2016)
SummarySelected CD8+ T cells must divide, produce differentiated effector cells, and self-renew, often repeatedly. We now show that silencing expression of the transcription factor TCF1 marks loss of self-renewal by determined effector cells and that