In-depth proteomic analyses of expressed prostatic secretions in urine for identification of prostate-enriched proteins

Autor: FONTANA, Simona, ALESSANDRO, Riccardo, Principe, S, Kim, Y, Ignatchenko, V, Nyalwidhe, JO, Lance, RS, Troyer, DA, Semmes, OJ, Drake, RR, Kislinger, T, Medin, JA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3658::be1207c41e5598dc060d8db02ea58baf
http://hdl.handle.net/10447/79333

Identification of Prostate-Enriched Proteins by In-depth Proteomic Analyses of Expressed Prostatic Secretions in Urine

Autor: Vladimir Ignatchenko, Thomas Kislinger, Yunee Kim, Simona Principe, Jeffrey A. Medin, Raymond S. Lance, Julius O. Nyalwidhe, Riccardo Alessandro, Dean A. Troyer, Richard R. Drake, Simona Fontana, O. John Semmes

Publikováno v: Journal of Proteome Research. 11:2386-2396

Urinary expressed prostatic secretion or "EPS-urine" is proximal tissue fluid that is collected after a digital rectal exam (DRE). EPS-urine is a rich source of prostate-derived proteins that can be used for biomarker discovery for prostate cancer (P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a0e875a057a2c1b7b5813be0ae45e2
https://doi.org/10.1021/pr2011236

Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes.

Autor: Khoo A; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada., Govindarajan M; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada., Qiu Z; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Urology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Liu LY; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada.; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Urology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Ignatchenko V; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada., Waas M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada., Macklin A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada., Keszei A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada., Neu S; Division of Surgery, Urology, Sunnybrook Health Sciences Centre, Toronto, ON, M4N 3M5, Canada., Main BP; Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA, 23507, USA., Yang L; Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, 23507, USA., Lance RS; Spokane Urology, Spokane, WA, 99202, USA., Downes MR; Division of Anatomic Pathology, Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, ON, M4N 3M5, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A8, Canada., Semmes OJ; Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, 23507, USA., Vesprini D; Department of Radiation Oncology, University of Toronto, Toronto, ON, M5T 1P5, Canada.; Odette Cancer Research Program, Sunnybrook Research Institute, Toronto, ON, M4N 3M5, Canada., Liu SK; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada.; Department of Radiation Oncology, University of Toronto, Toronto, ON, M5T 1P5, Canada.; Odette Cancer Research Program, Sunnybrook Research Institute, Toronto, ON, M4N 3M5, Canada., Nyalwidhe JO; Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, 23507, USA., Boutros PC; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada. PBoutros@mednet.ucla.edu.; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA. PBoutros@mednet.ucla.edu.; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA. PBoutros@mednet.ucla.edu.; Department of Urology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. PBoutros@mednet.ucla.edu.; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. PBoutros@mednet.ucla.edu.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada. PBoutros@mednet.ucla.edu.; Broad Stem Cell Research Center, University of California, Los Angeles, CA, 90095, USA. PBoutros@mednet.ucla.edu., Kislinger T; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada. thomas.kislinger@utoronto.ca.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada. thomas.kislinger@utoronto.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 13; Vol. 15 (1), pp. 5069. Date of Electronic Publication: 2024 Jun 13.

Prostate-specific membrane antigen (PSMA) glycoforms in prostate cancer patients seminal plasma.

Autor: Mackay S; Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia, USA.; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, USA.; Department of Neonatal-Perinatal Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Oduor IO; Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia, USA.; Department of Neurology, Children's Hospital of the Kings Daughters, Norfolk, Virginia, USA., Burch TC; Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia, USA.; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, USA., Troyer DA; Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia, USA.; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, USA., Semmes OJ; Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia, USA.; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, USA., Nyalwidhe JO; Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia, USA.; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, USA.

Publikováno v: The Prostate [Prostate] 2024 Apr; Vol. 84 (5), pp. 479-490. Date of Electronic Publication: 2023 Dec 27.

MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis.

Autor: Maji S; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Pradhan AK; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Kumar A; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Bhoopathi P; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Mannangatti P; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Guo C; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Windle JJ; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Subler MA; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Wang XY; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Semmes OJ; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507., Nyalwidhe JO; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507., Mukhopadhyay N; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; Department of Biostatistics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23238., Paul AK; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; Department of Internal Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23238., Hatfield B; Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23238., Levit MM; Department of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23238., Madan E; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; Department of Surgery, Virginia Commonwealth University, School of Medicine, Richmond, VA 23238., Sarkar D; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Emdad L; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Cohen DJ; Department of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23238., Gogna R; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Cavenee WK; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093., Das SK; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298., Fisher PB; Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.; VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Nov 07; Vol. 120 (45), pp. e2307094120. Date of Electronic Publication: 2023 Nov 03.