Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ny, Sin"'
Autor:
Cedric Lozano, Cristian Ramirez, Ny Sin, Hélène M.-F. Viart, Stanley B. Prusiner, Nick A. Paras, Jay Conrad
Publikováno v:
ACS Omega, Vol 6, Iss 14, Pp 9804-9812 (2021)
Externí odkaz:
https://doaj.org/article/88b235e477554950ac18e5d378cf370e
Autor:
Alicia Regueiro-Ren, Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob J. Swidorski, Zheng Liu, Brian L. Venables, Ny Sin, Richard A. Hartz, Tricia Protack, Zeyu Lin, Sharon Zhang, Zhufang Li, Dauh-Rurng Wu, Peng Li, James Kempson, Xiaoping Hou, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Hyunsoo Park, Amy Sarjeant, Yulia Benitex, Sandhya Rahematpura, Dawn Parker, Thomas Phillips, Roy Haskell, Susan Jenkins, Kenneth S. Santone, Mark Cockett, Umesh Hanumegowda, Ira Dicker, Nicholas A. Meanwell, Mark Krystal
Publikováno v:
Journal of medicinal chemistry. 65(18)
GSK3640254 is an HIV-1 maturation inhibitor (MI) that exhibits significantly improved antiviral activity toward a range of clinically relevant polymorphic variants with reduced sensitivity toward the second-generation MI GSK3532795 (BMS-955176). The
Autor:
Cristian Ramirez, Ny Sin, Cedric Lozano, Nick A. Paras, Jay Conrad, Hélène M.-F. Viart, Stanley B. Prusiner
Publikováno v:
ACS Omega, Vol 6, Iss 14, Pp 9804-9812 (2021)
ACS Omega
ACS omega, vol 6, iss 14
ACS Omega
ACS omega, vol 6, iss 14
In the literature, C-N coupling methods for the reaction of iodo-oxazole with 2-pyridinone were found to be low yielding. C-N coupling using silver benzoate additives with CuI catalysts and 4,7-dimethoxy-1,10-phenanthroline ligands has been developed
Autor:
Alicia Regueiro-Ren, Jacob J. Swidorski, Zheng Liu, Yan Chen, Ny Sin, Sing-Yuen Sit, Jie Chen, Brian L. Venables, Juliang Zhu, Beata Nowicka-Sans, Tricia Protack, Zeyu Lin, Brian Terry, Himadri Samanta, Sharon Zhang, Zhufang Li, John Easter, Brett R. Beno, Vinod Arora, Xiaohua S. Huang, Sandhya Rahematpura, Dawn D. Parker, Roy Haskell, Kenneth S. Santone, Mark I. Cockett, Mark Krystal, Nicholas A. Meanwell, Susan Jenkins, Umesh Hanumegowda, Ira B. Dicker
Publikováno v:
Journal of Medicinal Chemistry. 61:7289-7313
Autor:
Umesh Hanumegowda, Sharon Zhang, Yan Chen, Zheng Liu, Ira B. Dicker, Zhufang Li, Sing-Yuen Sit, Ny Sin, Jacob Swidorski, Brian Terry, Himadri Samanta, Tricia Protack, Brian Lee Venables, Zeyu Lin, Yongnian Sun, Jie Chen, Beata Nowicka-Sans, Alicia Regueiro-Ren, Nicholas A. Meanwell, Matthew D. Healy, Mark Krystal, Mark I. Cockett
Publikováno v:
Antimicrobial Agents and Chemotherapy
BMS-955176 is a second-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor (MI). A first-generation MI, bevirimat, showed clinical efficacy in early-phase studies, but ∼50% of subjects had viruses with reduced susceptibility
Autor:
Sing-Yuen Sit, Ny Sin, Umesh Hanumegowda, Dawn D. Parker, Zheng Liu, Alicia Regueiro-Ren, Xiaohua S. Huang, Brian Lee Venables, Brian Terry, Brett R. Beno, Sharon Zhang, Ira B. Dicker, Roy Haskell, Jacob Swidorski, Zhufang Li, Mark I. Cockett, Beata Nowicka-Sans, Zeyu Lin, Nicholas A. Meanwell, Tricia Protack, Sandhya Rahematpura, Juliang Zhu, Susan Jenkins, Himadri Samanta, Mark Krystal, Yan Chen, Kenneth S. Santone, Jie Chen
Publikováno v:
ACS Medicinal Chemistry Letters. 7:568-572
HIV-1 maturation inhibition (MI) has been clinically validated as an approach to the control of HIV-1 infection. However, identifying an MI with both broad polymorphic spectrum coverage and good oral exposure has been challenging. Herein, we describe
Autor:
NY Sin, MK Yuen, OC Li, TW Yeung, OC Leung, Jpk Tsang, CY Lee, W. Y. Chan, WY Wong, PY Chu, Vyk To
Publikováno v:
Hong Kong Journal of Radiology. :35-42
Autor:
Jacob Swidorski, Brian Lee Venables, Beata Nowicka-Sans, Sandhya Rahematpura, Zheng Liu, Ira B. Dicker, Jie Chen, Yan Chen, Brian Terry, Sing-Yuen Sit, Ny Sin, Umesh Hanumegowda, Tricia Protack, Susan Jenkins, Nicholas A. Meanwell, Dawn D. Parker, Alicia Regueiro-Ren, Mark Krystal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1925-1930
We have recently reported on the discovery of a C-3 benzoic acid (1) as a suitable replacement for the dimethyl succinate side chain of bevirimat (2), an HIV-1 maturation inhibitor that reached Phase II clinical trials before being discontinued. Rece
Autor:
Alicia, Regueiro-Ren, Jacob J, Swidorski, Zheng, Liu, Yan, Chen, Ny, Sin, Sing-Yuen, Sit, Jie, Chen, Brian L, Venables, Juliang, Zhu, Beata, Nowicka-Sans, Tricia, Protack, Zeyu, Lin, Brian, Terry, Himadri, Samanta, Sharon, Zhang, Zhufang, Li, John, Easter, Brett R, Beno, Vinod, Arora, Xiaohua S, Huang, Sandhya, Rahematpura, Dawn D, Parker, Roy, Haskell, Kenneth S, Santone, Mark I, Cockett, Mark, Krystal, Nicholas A, Meanwell, Susan, Jenkins, Umesh, Hanumegowda, Ira B, Dicker
Publikováno v:
Journal of medicinal chemistry. 61(16)
GSK3532795, formerly known as BMS-955176 (1), is a potent, orally active, second-generation HIV-1 maturation inhibitor (MI) that advanced through phase IIb clinical trials. The careful design, selection, and evaluation of substituents appended to the
Autor:
Umesh Hanumegowda, Sandhya Rahematpura, Sing-Yuen Sit, Ny Sin, Mark Krystal, Yan Chen, Jacob Swidorski, Brian Terry, Dawn D. Parker, Alicia Regueiro-Ren, Zeyu Lin, Nicholas A. Meanwell, Brian Lee Venables, Beata Nowicka-Sans, Zhufang Li, Zheng Liu, Tricia Protack, Susan Jenkins, Ira D. Dicker, Jie Chen
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(9)
The design and synthesis of a series of C28 amine-based betulinic acid derivatives as HIV-1 maturation inhibitors is described. This series represents a continuation of efforts following on from previous studies of C-3 benzoic acid-substituted betuli