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Drug and Chemical Glucosidation by Control Supersomes and Membranes from Spodoptera frugiperda (Sf) 9 Cells: Implications for the Apparent Glucuronidation of Xenobiotics by UDP-glucuronosyltransferase 1A5

Autor: Benjamin C. Lewis, Leyla Kaya, John O. Miners, Nuy Chau, Peter I. Mackenzie

Publikováno v: Drug Metabolism and Disposition. 47:271-278

Accumulating evidence indicates that several human UDP-glucuronosyltransferase (UGT) enzymes catalyze both glucuronidation and glucosidation reactions. Baculovirus-infected insect cells [Trichoplusia ni and Spodoptera frugiperda (Sf9)] are used widel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84af9d719b22ff02395bc3618c77daac
https://doi.org/10.1124/dmd.118.084947

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Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia

Autor: Nuy Chau, Kushari Burns, John O. Miners, Ross A. McKinnon, Kathleen M. Knights, Andrew Rowland, Geoffrey T. Tucker, Peter I. Mackenzie, Ganessan Kichenadasse

Publikováno v: Biochemical Pharmacology. 129:85-95

Kinase inhibitors (KIs) are a rapidly expanding class of drugs used primarily for the treatment of cancer. Data relating to the inhibition of UDP-glucuronosyltransferase (UGT) enzymes by KIs is sparse. However, lapatinib (LAP), pazopanib (PAZ), regor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e959039998f63e56349d6ee9b92dc7
https://doi.org/10.1016/j.bcp.2017.01.002

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Scaling factors for thein vitro-in vivoextrapolation (IV-IVE) of renal drug and xenobiotic glucuronidation clearance

Autor: John O. Miners, Nuy Chau, Kathleen M. Knights, Philip C. Smith, John K. Fallon, Shane M. Spencer

Publikováno v: British Journal of Clinical Pharmacology. 81:1153-1164

Aim To determine the scaling factors required for inclusion of renal drug glucuronidation clearance in the prediction of total clearance via glucuronidation (CLUGT ). Methods Microsomal protein per gram of kidney (MPPGK) was determined for human 'mix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15c245ccae609a4eada75a74457711ac
https://doi.org/10.1111/bcp.12889

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Drug and Chemical Glucosidation by Control Supersomes and Membranes from

Autor: Nuy, Chau, Leyla, Kaya, Benjamin C, Lewis, Peter I, Mackenzie, John O, Miners

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 47(3)

Accumulating evidence indicates that several human UDP-glucuronosyltransferase (UGT) enzymes catalyze both glucuronidation and glucosidation reactions. Baculovirus-infected insect cells [

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af4d74f44cc5be3ff7b3147d01fa5181
https://pubmed.ncbi.nlm.nih.gov/30541877

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Scaling factors for the in vitro-in vivo extrapolation (IV-IVE) of renal drug and xenobiotic glucuronidation clearance

Autor: Kathleen M, Knights, Shane M, Spencer, John K, Fallon, Nuy, Chau, Philip C, Smith, John O, Miners

Publikováno v: British journal of clinical pharmacology. 81(6)

To determine the scaling factors required for inclusion of renal drug glucuronidation clearance in the prediction of total clearance via glucuronidation (CLUGT ).Microsomal protein per gram of kidney (MPPGK) was determined for human 'mixed' kidney (n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79b60275445fdd81ba51171a9a4f39e3
https://pubmed.ncbi.nlm.nih.gov/26808419

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The Novel UDP Glycosyltransferase 3A2: Cloning, Catalytic Properties, and Tissue Distribution

Autor: Peter I. Mackenzie, John O. Miners, Nuy Chau, Anne Rogers, David J. Elliot, Julie-Ann Hulin, Robyn Meech

Publikováno v: Molecular Pharmacology. 79:472-478

The human UDP glycosyltransferase (UGT) 3A family is one of three families involved in the metabolism of small lipophilic compounds. Members of these families catalyze the addition of sugar residues to chemicals, which enhances their excretion from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca71cf2391763aebeb18e52ae3c8732d
https://doi.org/10.1124/mol.110.069336

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Marked Reduction in Obstructive Sleep Apnea Severity in Slow Wave Sleep

Autor: Aeneas Yeo, Daniel Stadler, Rajeev Ratnavadivel, R. Doug McEvoy, Nuy Chau, Peter Catcheside

Publikováno v: Journal of Clinical Sleep Medicine. :519-524

Introduction:Obstructive sleep apnea (OSA) is widely accepted to improve during slow wave sleep (SWS) compared to lighter stages of NREM sleep. However, supporting data to establish the magnitude a...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98dee9a589e156a363360a96496c0216
https://doi.org/10.5664/jcsm.27651

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Inhibition of Human UDP-Glucuronosyltransferase Enzymes by Canagliflozin and Dapagliflozin: Implications for Drug-Drug Interactions

Autor: Attarat Pattanawongsa, Andrew Rowland, Nuy Chau, John O. Miners

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 43(10)

Canagliflozin (CNF) and dapagliflozin (DPF) are the first sodium-glucose cotransporter 2 inhibitors to be approved for clinical use. Although available evidence excludes clinically significant inhibition of cytochromes P450, the effects of CNF and DP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8423517c2a787a4b5b286e6045708f38
https://pubmed.ncbi.nlm.nih.gov/26180128

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