Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nuwan C. Hettige"'
Autor:
Nuwan C. Hettige, Carl Ernst
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2019)
Brain development is a highly regulated process that involves the precise spatio-temporal activation of cell signaling cues. Transcription factors play an integral role in this process by relaying information from external signaling cues to the genom
Externí odkaz:
https://doaj.org/article/e4512f8d38964390b60716b69639c558
Autor:
Nuwan C Hettige, Peter Fleming, Amelia Semenak, Xin Zhang, Huashan Peng, Marc-Daniel Hagel, Jean-François Théroux, Ying Zhang, Anjie Ni, Malvin Jefri, Lilit Antonyan, Shaima Alsuwaidi, Andreas Schuppert, Patrick S Stumpf, Carl Ernst
Publikováno v:
Human Molecular Genetics.
FOXG1 is a critical transcription factor in human brain where loss-of-function mutations cause a severe neurodevelopmental disorder, while increased FOXG1 expression is frequently observed in glioblastoma. FOXG1 is an inhibitor of cell patterning and
Autor:
Thad A. Rosenberger, Patrick S. Stumpf, Naguib Mechawar, Carl Ernst, Liam Crapper, Nahum Sonenberg, Luc Moquin, Liam Anuj O’Leary, Jelena Popic, Andreas Schuppert, Xin Zhang, Hyder A. Jinnah, Scott C. Bell, Huashan Peng, Ilse Gantois, Alain Gratton, Michel L. Tremblay, Lilit Antonyan, Hanrong Wu, Diane J. Sutcliffe, Nuwan C. Hettige, Malvin Jefri, Vincent McCarty, Ying Zhang, Ilaria Kolobova
Publikováno v:
Stem Cell Reports
Stem cell reports 16(7), 1749-1762 (2021). doi:10.1016/j.stemcr.2021.06.003
Stem cell reports 16(7), 1749-1762 (2021). doi:10.1016/j.stemcr.2021.06.003
Summary Mutations in HPRT1, a gene encoding a rate-limiting enzyme for purine salvage, cause Lesch-Nyhan disease which is characterized by self-injury and motor impairments. We leveraged stem cell and genetic engineering technologies to model the dis
Autor:
Liam Anuj O’Leary, Naguib Mechawar, Heika Silveira, Jeyashree Krishnan, Carl Ernst, Hanrong Wu, Andreas Schuppert, Ying Zhang, Xin Zhang, Lilit Antonyan, Nuwan C. Hettige, Vincent McCarty, Edward A. Fon, Luc Moquin, Huashan Peng, Zahia Aouabed, Malvin Jefri, Gilles Maussion, Thomas M. Durcan, Vincent Soubannier, Scott C. Bell, Jean-François Théroux, Alain Gratton
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 6, Pp 697-712 (2020)
Stem Cells Translational Medicine
Stem Cells Translational Medicine
Making high‐quality dopamine (DA)‐producing cells for basic biological or small molecule screening studies is critical for the development of novel therapeutics for disorders of the ventral midbrain. Currently, many ventral midbrain assays have l
Autor:
Nuwan C. Hettige, Huashan Peng, Hanrong Wu, Xin Zhang, Volodymyr Yerko, Ying Zhang, Malvin Jefri, Vincent Soubannier, Gilles Maussion, Shaima Alsuwaidi, Anjie Ni, Cecilia Rocha, Jeyashree Krishnan, Vincent McCarty, Lilit Antonyan, Andreas Schuppert, Gustavo Turecki, Edward A. Fon, Thomas M. Durcan, Carl Ernst
Publikováno v:
Stem cell reports 17(3), 475-488 (2022). doi:10.1016/j.stemcr.2022.01.010
Stem cell reports 17(3), 475-488 (2022). doi:10.1016/j.stemcr.2022.01.010
Published by Cell Press, Maryland Heights, MO
Published by Cell Press, Maryland Heights, MO
Autor:
Ariel Graff, Samia Tasmim, James L. Kennedy, Danilo Rocha de Jesus, Oluwagbenga Dada, Nuwan C. Hettige, Philip Gerretsen, Ali Bani-Fatemi, Andrea de Bartolomeis, Clement C. Zai, Vincenzo De Luca
Publikováno v:
Comprehensive Psychiatry, Vol 89, Iss, Pp 28-32 (2019)
Background: Treatment resistance is a common issue among schizophrenia patients undergoing antipsychotic treatment. According to the American Psychiatric Association (APA) guidelines, treatment-resistant status is defined as little or no symptom redu
Autor:
Clement C. Zai, Justin Huang, Julia Tomasi, Arun K. Tiwari, Nela Pivac, Eric Huang, Gwyneth Zai, Matea Nikolac Perkovic, James L. Kennedy, Nuwan C. Hettige
Publikováno v:
The Pharmacogenomics Journal. 19:269-276
Brain-derived neurotrophic factor (BDNF) plays an important role in dopaminergic and serotonergic neurotransmission by modulating dopaminergic neuron differentiation and establishment. Multiple studies have analyzed the functional BDNF Val66Met varia
Publikováno v:
International Journal of Neuropsychopharmacology
Some intellectual disability syndromes are caused by a mutation in a single gene and have been the focus of therapeutic intervention attempts, such as Fragile X and Rett Syndrome, albeit with limited success. The rate at which new drugs are discovere
Publikováno v:
CNS Spectrums. 23:253-263
The risk of suicide is greatly increased in individuals with schizophrenia. Previous research has identified several potential risk factors for suicidal behavior in schizophrenia, although their ability to independently predict suicide is limited. Th
Autor:
Heika Silveira, Hanrong Wu, Xin Zhang, Scott C. Bell, Ying Zhang, Lilit Antonyan, Nuwan C. Hettige, Carl Ernst, Huashan Peng, Malvin Jefri
Publikováno v:
Bio Protoc
Induced Pluripotent Stem Cells (iPSCs) are pluripotent stem cells that can be generated from somatic cells, and provide a way to model the development of neural tissues in vitro. One particularly interesting application of iPSCs is the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad0b9912acc390826027a1e29c1a635
https://europepmc.org/articles/PMC7854068/
https://europepmc.org/articles/PMC7854068/