Zobrazeno 1 - 10
of 814
pro vyhledávání: '"Nutrient deprivation"'
Autor:
Longhao Cheng, Xiaoxue Wang, Aijun Liu, Ying Zhu, Hu Cheng, Jiangling Yu, Lili Gong, Honglin Liu, Guolin Shen, Lihong Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3493-3512 (2024)
Amino acid metabolic remodeling is a hallmark of cancer, driving an increased nutritional demand for amino acids. Amino acids are pivotal for energetic regulation, biosynthetic support, and homeostatic maintenance to stimulate cancer progression. How
Externí odkaz:
https://doaj.org/article/6bbd17712b8949efb459534917975d92
Autor:
Qi Gao, Yingying Jiang, Zhenqiang Song, Huizhu Ren, Yan Kong, Cong Wang, Miaoyan Zheng, Chunyan Shan, Yanhui Yang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Lipid peroxidation and mitochondrial damage impair insulin sensitivity in skeletal muscle. Sirtuin-1 (SIRT1) protects mitochondria and activates under energy restriction. Dapagliflozin (Dapa) is an antihyperglycaemic agent that belongs to th
Externí odkaz:
https://doaj.org/article/f864967b1e704871a9f4f74eab9f24c3
Autor:
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhiy V., Minchenko Dmytro O.
Publikováno v:
Endocrine Regulations, Vol 58, Iss 1, Pp 144-152 (2024)
Objective. Serine hydroxymethyltransferase (SHMT2) plays a multifunctional role in mitochondria (folate-dependent tRNA methylation, translation, and thymidylate synthesis). The endoplasmic reticulum stress, hypoxia, and glucose and glutamine supply a
Externí odkaz:
https://doaj.org/article/8492f2f39bcd4c8f97216ef7a540237f
Autor:
Gabriele Paglialunga, Christophe El Nakhel, Simona Proietti, Stefano Moscatello, Alberto Battistelli, Luigi Formisano, Michele Ciriello, Marta Del Bianco, Stefania De Pascale, Youssef Rouphael
Publikováno v:
Frontiers in Sustainable Food Systems, Vol 7 (2023)
Long-term space missions will require a self-sustaining food production system to meet the crew’s nutritional and health needs. For this purpose, plant-based food production systems with elevated resource efficiency are required, based on advanced
Externí odkaz:
https://doaj.org/article/706ec023e5f84e0188343758350ec9ba
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 1, p 27 (2024)
Background: The pentose phosphate pathway (PPP) is a critical metabolic pathway that generates NADPH and ribose-5-phosphate for nucleotide biosynthesis and redox homeostasis. In this study, we investigated a potential regulatory role for Krüppel-lik
Externí odkaz:
https://doaj.org/article/43a6cfb8206f4c428dc83d2ff28a0761
Autor:
Caterina Giraulo, Roberta Turiello, Lavinia Orlando, Sonia Leonardelli, Jennifer Landsberg, Raffaella Belvedere, Georg Rolshoven, Christa E. Müller, Michael Hölzel, Silvana Morello
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115225- (2023)
CD73 is the key enzyme in the generation of extracellular adenosine, a mediator involved in tumor progression, tumor immune escape and resistance to anti-cancer therapeutics. Microenvironmental conditions influence the expression of CD73 in tumor cel
Externí odkaz:
https://doaj.org/article/2d01d7fab2754c648cad5647ebf10af7
Autor:
Valentin J. A. Barthet, Kevin M. Ryan
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 170-174 (2022)
Macroautophagy/autophagy is a conserved catabolic process that delivers intracellular materials to lysosomes for degradation. This process promotes cell survival by maintaining cellular homeostasis and supplying substrates to produce energy during nu
Externí odkaz:
https://doaj.org/article/39ca68d79311445f8694af162d9edd9a
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-20 (2022)
Abstract The tumor microenvironment (TME) has been demonstrated to modulate the biological behavior of tumors intensively. Multiple stress conditions are widely observed in the TME of many cancer types, such as hypoxia, inflammation, and nutrient dep
Externí odkaz:
https://doaj.org/article/7ff9a410af324aa59a244ed10ec93f5a
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