snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses.

Autor: Macnair W; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland. Electronic address: will.macnair@roche.com., Calini D; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Agirre E; Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden., Bryois J; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Jäkel S; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians Universität, Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany., Smith RS; Centre for Regenerative Medicine, Institute for Regeneration and Repair, MS Society Edinburgh Centre for MS Research, The University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK., Kukanja P; Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden., Stokar-Regenscheit N; Roche Pharma Research and Early Development (pRED), Pharmaceutical Sciences, Pathology and Applied Safety Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Ott V; Roche Pharma Research and Early Development (pRED), Pharmaceutical Sciences, Pathology and Applied Safety Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Foo LC; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Collin L; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Schippling S; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Urich E; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Nutma E; Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Marzin M; Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Ansaloni F; Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden., Amor S; Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Magliozzi R; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Heidari E; Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Robinson MD; Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Ffrench-Constant C; Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK. Electronic address: cffc@uea.ac.uk., Castelo-Branco G; Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address: goncalo.castelo-branco@ki.se., Williams A; Centre for Regenerative Medicine, Institute for Regeneration and Repair, MS Society Edinburgh Centre for MS Research, The University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK. Electronic address: anna.williams@ed.ac.uk., Malhotra D; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland. Electronic address: dheeraj21malhotra@gmail.com.

Publikováno v: Neuron [Neuron] 2024 Dec 20. Date of Electronic Publication: 2024 Dec 20.

Human post-mortem organotypic brain slice cultures: a tool to study pathomechanisms and test therapies.

Autor: Plug BC; Department of Paediatrics and Child Neurology, Emma Children's Hospital, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands.; Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam Neuroscience, Cellular & Molecular Mechanisms, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands., Revers IM; Department of Paediatrics and Child Neurology, Emma Children's Hospital, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands.; Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam Neuroscience, Cellular & Molecular Mechanisms, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands., Breur M; Department of Paediatrics and Child Neurology, Emma Children's Hospital, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands.; Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam Neuroscience, Cellular & Molecular Mechanisms, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands., González GM; Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam University Medical Centre, VU University, Amsterdam Neuroscience, De Boelelaan 1108, Amsterdam, 1081 HZ, The Netherlands., Timmerman JA; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam Neuroscience, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands., Meijns NRC; Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam University Medical Centre, VU University, Amsterdam Neuroscience, De Boelelaan 1108, Amsterdam, 1081 HZ, The Netherlands., Hamberg D; Department of Paediatrics and Child Neurology, Emma Children's Hospital, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands.; Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam Neuroscience, Cellular & Molecular Mechanisms, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands., Wagendorp J; Department of Paediatrics and Child Neurology, Emma Children's Hospital, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands.; Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam Neuroscience, Cellular & Molecular Mechanisms, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands., Nutma E; Department of Pathology, Amsterdam Neuroscience, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands., Wolf NI; Department of Paediatrics and Child Neurology, Emma Children's Hospital, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands.; Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam Neuroscience, Cellular & Molecular Mechanisms, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands., Luchicchi A; Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam University Medical Centre, VU University, Amsterdam Neuroscience, De Boelelaan 1108, Amsterdam, 1081 HZ, The Netherlands., Mansvelder HD; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam Neuroscience, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands., van Til NP; Department of Paediatrics and Child Neurology, Emma Children's Hospital, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands.; Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam Neuroscience, Cellular & Molecular Mechanisms, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam Neuroscience, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands., van der Knaap MS; Department of Paediatrics and Child Neurology, Emma Children's Hospital, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands.; Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam Neuroscience, Cellular & Molecular Mechanisms, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam Neuroscience, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands., Bugiani M; Department of Paediatrics and Child Neurology, Emma Children's Hospital, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands. m.bugiani@amsterdamumc.nl.; Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam Neuroscience, Cellular & Molecular Mechanisms, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. m.bugiani@amsterdamumc.nl.; Department of Pathology, Amsterdam Neuroscience, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1100 DD, The Netherlands. m.bugiani@amsterdamumc.nl.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 May 31; Vol. 12 (1), pp. 83. Date of Electronic Publication: 2024 May 31.

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.

Autor: Nutma E; Department of Pathology, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands.; Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, The Netherlands., Fancy N; Department of Brain Sciences, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK., Weinert M; Department of Brain Sciences, Imperial College London, London, UK., Tsartsalis S; Department of Brain Sciences, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Psychiatry, University of Geneva, Geneva, Switzerland., Marzin MC; Department of Pathology, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands., Muirhead RCJ; Department of Brain Sciences, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK., Falk I; Viral Immunology Section, NIH, Bethesda, MD, USA.; Flow and Imaging Cytometry Core Facility, NIH, Bethesda, MD, USA., Breur M; Department of Pathology, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands., de Bruin J; Department of Pathology, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands., Hollaus D; Department of Pathology, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands., Pieterman R; Department of Pathology, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands., Anink J; Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Story D; UK Dementia Research Institute at Edinburgh, Edinburgh, UK., Chandran S; UK Dementia Research Institute at Edinburgh, Edinburgh, UK., Tang J; Department of Brain Sciences, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK., Trolese MC; Department of Neuroscience, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy., Saito T; Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan., Saido TC; Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University, Nagoya, Japan., Wiltshire KH; Department of Brain Sciences, Imperial College London, London, UK., Beltran-Lobo P; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Phillips A; Department of Brain Sciences, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK., Antel J; Montreal Neurological Institute, McGill University, Montreal, Canada., Healy L; Montreal Neurological Institute, McGill University, Montreal, Canada., Dorion MF; Division of Biomedical Sciences, Memorial University of Newfoundland, St. John's, Canada., Galloway DA; Division of Biomedical Sciences, Memorial University of Newfoundland, St. John's, Canada., Benoit RY; Division of Biomedical Sciences, Memorial University of Newfoundland, St. John's, Canada., Amossé Q; Department of Psychiatry, University of Geneva, Geneva, Switzerland., Ceyzériat K; Department of Psychiatry, University of Geneva, Geneva, Switzerland., Badina AM; Department of Psychiatry, University of Geneva, Geneva, Switzerland., Kövari E; Department of Psychiatry, University of Geneva, Geneva, Switzerland., Bendotti C; Department of Neuroscience, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy., Aronica E; Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Radulescu CI; Department of Brain Sciences, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK., Wong JH; Neurobiology of Aging and Disease Laboratory, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore., Barron AM; Neurobiology of Aging and Disease Laboratory, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore., Smith AM; UK Dementia Research Institute at Imperial College London, London, UK.; Centre for Brain Research and Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand., Barnes SJ; Department of Brain Sciences, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK., Hampton DW; UK Dementia Research Institute at Edinburgh, Edinburgh, UK., van der Valk P; Department of Pathology, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands., Jacobson S; Viral Immunology Section, NIH, Bethesda, MD, USA., Howell OW; Institute of Life Science (ILS), Swansea University Medical School, Swansea, UK., Baker D; Department of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK., Kipp M; Institute of Anatomy, Rostock University Medical Center, 18057, Rostock, Germany., Kaddatz H; Institute of Anatomy, Rostock University Medical Center, 18057, Rostock, Germany., Tournier BB; Department of Psychiatry, University of Geneva, Geneva, Switzerland., Millet P; Department of Psychiatry, University of Geneva, Geneva, Switzerland.; Division of Adult Psychiatry, University Hospitals of Geneva, Geneva, Switzerland., Matthews PM; Department of Brain Sciences, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK., Moore CS; Division of Biomedical Sciences, Memorial University of Newfoundland, St. John's, Canada., Amor S; Department of Pathology, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands. s.amor@amsterdamumc.nl.; Department of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK. s.amor@amsterdamumc.nl.; Institute of Anatomy, Rostock University Medical Center, 18057, Rostock, Germany. s.amor@amsterdamumc.nl., Owen DR; Department of Brain Sciences, Imperial College London, London, UK. d.owen@imperial.ac.uk.; UK Dementia Research Institute at Imperial College London, London, UK. d.owen@imperial.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2023 Aug 28; Vol. 14 (1), pp. 5247. Date of Electronic Publication: 2023 Aug 28.

Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis.

Autor: Gorter, R. P.¹, Nutma, E.¹, Jahrei, M.‐C.¹, de Jonge, J. C.², Quinlan, R. A³, Valk, P.¹, Noort, J. M.⁴, Baron, W.², Amor, S.^1,5 s.amor@vumc.nl

Publikováno v: Clinical & Experimental Immunology. Nov2018, Vol. 194 Issue 2, p137-152. 16p. 4 Color Photographs, 1 Diagram, 1 Chart, 1 Graph.

Transmembrane protein 119 is neither a specific nor a reliable marker for microglia.

Autor: Vankriekelsvenne E; Rostock University Medical Center, Institute of Anatomy, Rostock, Germany., Chrzanowski U; Rostock University Medical Center, Institute of Anatomy, Rostock, Germany.; Faculty of Medicine, LMU Munich, Institute of Anatomy II, Munich, Germany., Manzhula K; Rostock University Medical Center, Institute of Anatomy, Rostock, Germany., Greiner T; Rostock University Medical Center, Institute of Anatomy, Rostock, Germany., Wree A; Rostock University Medical Center, Institute of Anatomy, Rostock, Germany., Hawlitschka A; Rostock University Medical Center, Institute of Anatomy, Rostock, Germany., Llovera G; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany., Zhan J; Rostock University Medical Center, Institute of Anatomy, Rostock, Germany., Joost S; Rostock University Medical Center, Institute of Anatomy, Rostock, Germany., Schmitz C; Faculty of Medicine, LMU Munich, Institute of Anatomy II, Munich, Germany., Ponsaerts P; Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Wilrijk, Belgium., Amor S; Department of Pathology, Amsterdam UMC, VUMC Site, Amsterdam, The Netherlands.; Barts and The London School of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK., Nutma E; Department of Pathology, Amsterdam UMC, VUMC Site, Amsterdam, The Netherlands., Kipp M; Rostock University Medical Center, Institute of Anatomy, Rostock, Germany., Kaddatz H; Rostock University Medical Center, Institute of Anatomy, Rostock, Germany.

Publikováno v: Glia [Glia] 2022 Jun; Vol. 70 (6), pp. 1170-1190. Date of Electronic Publication: 2022 Mar 04.