Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Nuska Tschammer"'
Autor:
Namita Kundu, Xinrong Ma, Regine Brox, Xiaoxuan Fan, Tyler Kochel, Jocelyn Reader, Nuska Tschammer, Amy Fulton
Publikováno v:
Breast Cancer: Basic and Clinical Research, Vol 13 (2019)
We are seeking to identify molecular targets that are relevant to breast cancer cells with stem-like properties. There is growing evidence that cancer stem cells (CSCs) are supported by inflammatory mediators expressed in the tumor microenvironment.
Externí odkaz:
https://doaj.org/article/558687a92e974adc831f6475f8a4d6f9
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100069 (2014)
Partial agonists exhibit a submaximal capacity to enhance the coupling of one receptor to an intracellular binding partner. Although a multitude of studies have reported different ligand-specific conformations for a given receptor, little is known ab
Externí odkaz:
https://doaj.org/article/9db6f013c0b64f99ae903a1fd26a6b9c
Autor:
Tanja, Bartoschik, Amit, Gupta, Beate, Kern, Andrew, Hitchcock, Nathan B P, Adams, Nuska, Tschammer
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2168
The combination of MicroScale Thermophoresis (MST) and near-native site-specific His-tag labeling enables simple, robust, and reliable determination of the binding affinity between proteins and ligands. To demonstrate its applicability for periplasmi
Autor:
Werner Streicher, Christin Pohl, Alexander P. Golovanov, Pernille Harris, Matja Zalar, Sowmya Indrakumar, Nuska Tschammer, Allan Nørgaard, Günther H.J. Peters
Publikováno v:
Indrakumar, S, Zalar, M, Tschammer, N, Pohl, C A, Nørgaard, A, Streicher, W, Harris, P, Golovanov, A P & Peters, G H J 2021, ' Development of a Fast Screening Method for Selecting Excipients in Formulations using MD simulations, NMR and MicroScale Thermophoresis ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 158, pp. 11-20 . https://doi.org/10.1016/j.ejpb.2020.10.015
Development of peptide therapeutics generally involves screening of excipients that inhibit peptide-peptide interactions, hence aggregation, and improve peptide stability. We used the therapeutic peptide plectasin to develop a fast screening method t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a53ed78bec97c51dee0259e918874e4
https://orbit.dtu.dk/en/publications/4305e7c3-4649-4809-9959-fe8436ce07c3
https://orbit.dtu.dk/en/publications/4305e7c3-4649-4809-9959-fe8436ce07c3
Autor:
Nuska Tschammer, Monica De Maria, Daniel G Silva, Michael Koch, Natalia V. Ortiz Zacarías, Fernando de Moura Gatti, Sven Hermann, Anna Junker, Laura H. Heitman, Annelien J.M. Zweemer, Christina Weiss, Klaus Kopka, Dirk Schepmann, Stefan Wagner
Publikováno v:
ChemMedChem, 16(4), 640-645
ChemMedChem
ChemMedChem 16(2021)4, 640-645
Chemmedchem
ChemMedChem
ChemMedChem 16(2021)4, 640-645
Chemmedchem
Herein we report the design and synthesis of a series of highly selective CCR2 antagonists as 18F‐labeled PET tracers. The derivatives were evaluated extensively for their off‐target profile at 48 different targets. The most potent and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392db723f0fe9d81b37ab25eabe4f515
http://hdl.handle.net/1887/3134856
http://hdl.handle.net/1887/3134856
Autor:
Michaela Blech, Richard Melien, Nuska Tschammer, Beate Presser, Dariush Hinderberger, Patrick Garidel
Publikováno v:
Pharmaceutical researchReferences. 38(12)
Introduction of the activation energy (EEEE
Autor:
Beate Kern, Nathan B. P. Adams, Andrew Hitchcock, Amit J. Gupta, Nuska Tschammer, Tanja Bartoschik
Publikováno v:
Methods in Molecular Biology ISBN: 9781071607237
The combination of MicroScale Thermophoresis (MST) and near-native site-specific His-tag labeling enables simple, robust, and reliable determination of the binding affinity between proteins and ligands. To demonstrate its applicability for periplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bbe5b67218f3d03c105f325742e7507
https://doi.org/10.1007/978-1-0716-0724-4_2
https://doi.org/10.1007/978-1-0716-0724-4_2
Publikováno v:
Journal of Proteins and Proteomics, Vol 9, Iss 1, Pp 73-76 (2018)
While it’s very common for biologists and chemists to test whether or not two molecules interact with each other, it’s much more useful to gather information on the nature of that interaction. How strong is it? How long will it last? What does th
Autor:
Christian Kleusch, Katarzyna Walkiewicz, Dirk Daelemans, Yves A. Muller, Tanja Bartoschik, Sebastian Weigert, Stefanie Galinec, Thomas Vercruysse, Dennis Breitsprecher, Changjiang You, Nuska Tschammer, Jacob Piehler
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
BASE-Bielefeld Academic Search Engine
Scientific Reports
BASE-Bielefeld Academic Search Engine
Scientific Reports
MicroScale Thermophoresis (MST) is a frequently used method for the quantitative characterization of intermolecular interactions with several advantages over other technologies. One of these is its capability to determine equilibrium constants in sol
Autor:
Christina Weiss, Simone Thum, Anna Junker, Natalia V. Ortiz Zacarías, Artur K. Kokornaczyk, Henk de Vries, Masato Kitamura, Bernhard Wünsch, Laura H. Heitman, Michael Koch, Tomoaki Seki, Nuska Tschammer, Monica De Maria, Dirk Schepmann
Publikováno v:
European Journal of Medicinal Chemistry, 135, 401-413
Targeting CCR2 and CCR5 receptors is considered as promising concept for the development of novel antiinflammatory drugs. Herein, we present the development of the first probe-dependent positive allosteric modulator (PAM) of CCR5 receptors with a 2-b