Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nurten Yigit"'
Autor:
An De Weer, Frank Speleman, Barbara Cauwelier, Nadine Van Roy, Nurten Yigit, Bruno Verhasselt, Barbara De Moerloose, Yves Benoit, Lucien Noens, Dominik Selleslag, Eric Lippert, Stephanie Struski, Christian Bastard, Anne De Paepe, Peter Vandenberghe, Anne Hagemeijer, Nicole Dastugue, Bruce Poppe
Publikováno v:
Haematologica, Vol 93, Iss 12 (2008)
Chromosomal translocations involving the EVI1 locus are a recurrent finding in myeloid leukemia and are associated with poor prognosis. In this study, we performed a detailed molecular characterization of the recurrent translocation t(3;17)(q26;q22)
Externí odkaz:
https://doaj.org/article/e91eb8017e2041a495f7094bc13825ce
Autor:
Frank Speleman, Jo Vandesompele, Anne De Paepe, Frank Westermann, Jean-Christophe Marine, Nurten Yigit, Sarah De Clercq, Daniel Dreidax, Ali Rihani, Tom Van Maerken
Supplementary Methods, Tables 1-2, Figures 1-3 from Functional Analysis of the p53 Pathway in Neuroblastoma Cells Using the Small-Molecule MDM2 Antagonist Nutlin-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9cbb8967108c4bb241607fe83bf147
https://doi.org/10.1158/1535-7163.22496379
https://doi.org/10.1158/1535-7163.22496379
Autor:
Frank Speleman, Jo Vandesompele, Anne De Paepe, Frank Westermann, Jean-Christophe Marine, Nurten Yigit, Sarah De Clercq, Daniel Dreidax, Ali Rihani, Tom Van Maerken
Suppression of p53 activity is essential for proliferation and survival of tumor cells. A direct p53-activating compound, nutlin-3, was used in this study, together with p53 mutation analysis, to characterize p53 pathway defects in a set of 34 human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b127f532b2ef0a1caed9a98f565251
https://doi.org/10.1158/1535-7163.c.6535251
https://doi.org/10.1158/1535-7163.c.6535251
Autor:
Jo Vandesompele, Jean-Christophe Marine, Anne De Paepe, Jan Philippé, Vicky Coppens, Nurten Yigit, Els De Smet, Sarah De Clercq, Irina Lambertz, Joëlle Vermeulen, Frank Speleman, Tom Van Maerken
Supplementary Figures 1-5 from Small-Molecule MDM2 Antagonists as a New Therapy Concept for Neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9014f11378afdee72c6d21ae908d80ce
https://doi.org/10.1158/0008-5472.22364930
https://doi.org/10.1158/0008-5472.22364930
Autor:
Jo Vandesompele, Jean-Christophe Marine, Anne De Paepe, Jan Philippé, Vicky Coppens, Nurten Yigit, Els De Smet, Sarah De Clercq, Irina Lambertz, Joëlle Vermeulen, Frank Speleman, Tom Van Maerken
Circumvention of the p53 tumor suppressor barrier in neuroblastoma is rarely caused by TP53 mutation but might arise from inappropriately increased activity of its principal negative regulator MDM2. We show here that targeted disruption of the p53-MD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f8c8a146b11e268d728dec231fa479
https://doi.org/10.1158/0008-5472.c.6494438
https://doi.org/10.1158/0008-5472.c.6494438
Autor:
Alan Van Goethem, Jill Deleu, Nurten Yigit, Celine Everaert, Myrthala Moreno-Smith, Sanjeev A Vasudevan, Fjoralba Zeka, Fleur Demuynck, Eveline Barbieri, Frank Speleman, Pieter Mestdagh, Jason Shohet, Jo Vandesompele, Tom Van Maerken
Publikováno v:
NAR CANCER
Accurate assessment of treatment response and residual disease is indispensable for the evaluation of cancer treatment efficacy. However, performing tissue biopsies for longitudinal follow-up poses a major challenge in the management of solid tumours
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db5116d182701d6347b9cc54e88e877
https://hdl.handle.net/1854/LU-01GQ4PZYZ4ZEY4134GJ5CEX40T
https://hdl.handle.net/1854/LU-01GQ4PZYZ4ZEY4134GJ5CEX40T
Autor:
Marieke Vromman, Jasper Anckaert, Stefania Bortoluzzi, Alessia Buratin, Chia-Ying Chen, Qinjie Chu, Trees-Juen Chuang, Roozbeh Dehghannasiri, Christoph Dieterich, Xin Dong, Paul Flicek, Enrico Gaffo, Wanjun Gu, Chunjiang He, Steve Hoffmann, Osagie Izuogu, Michael S. Jackson, Tobias Jakobi, Eric C. Lai, Justine Nuytens, Julia Salzman, Mauro Santibanez-Koref, Peter Stadler, Olivier Thas, Eveline Vanden Eynde, Kimberly Verniers, Guoxia Wen, Jakub Westholm, Li Yang, Chu-Yu Ye, Nurten Yigit, Guo-Hua Yuan, Jinyang Zhang, Fangqing Zhao, Jo Vandesompele, Pieter-Jan Volders
The detection of circular RNA molecules (circRNAs) is typically based on short-read RNA sequencing data processed by computational detection tools. During the last decade, a plethora of such tools have been developed, but a systematic comparison with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110a536623d837fc2b96c3617b91a7f2
https://hdl.handle.net/11577/3488201
https://hdl.handle.net/11577/3488201
Autor:
Jo Vandesompele, Justine Nuytens, Aart G. Jochemsen, Didier Decaudin, Fariba Nemati, Jilke De Wilde, Manuel Rodrigues, Rudy Van Coster, Eleonora Leucci, Joél Smet, Louis Delhaye, Peihua Zhao, Shanna Dewaele, Pieter Mestdagh, Jasper Anckaert, Sven Eyckerman, Katrien Vanderheyden, Eric James de Bony, Maxime Verschoore, Boel De Paepe, Jo Van Dorpe, Jean-Christophe Marine, Nurten Yigit, Eveline Vanden Eynde
Publikováno v:
Oncogene
ONCOGENE
ONCOGENE
Long non-coding RNAs (lncRNAs) can exhibit cell-type and cancer-type specific expression profiles, making them highly attractive as therapeutic targets. Pan-cancer RNA sequencing data revealed broad expression of the SAMMSON lncRNA in uveal melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2581ad7896383dcdd1dbb534b7c760
https://doi.org/10.1038/s41388-021-02006-x
https://doi.org/10.1038/s41388-021-02006-x
Autor:
Eric de Bony, Fien Gysens, Nurten Yigit, Jasper Anckaert, Celine Everaert, Eveline Vanden Eynde, Kimberly Verniers, Willem van Snippenberg, Wim Trypsteen, Pieter Mestdagh
Publikováno v:
Biotechnology journalREFERENCES. 17(9)
Molecular phenotyping through shallow 3'-end RNA-sequencing workflows is increasingly applied in the context of large-scale chemical or genetic perturbation screens to study disease biology or support drug discovery. While these workflows enable accu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abd6a2886d7be6f9f61e65093625f3d
https://pubmed.ncbi.nlm.nih.gov/35535560
https://pubmed.ncbi.nlm.nih.gov/35535560
mTOR inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells
Autor:
Sven Eyckerman, Bram Bogaert, Boel De Paepe, Shanna Dewaele, Nurten Yigit, Pieter Mestdagh, Jasper Anckaert, Justine Nuytens, Ramiro Martinez, Koen Raemdonck, Rudy Van Coster, Louis Delhaye
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Due to a lack of effective treatments, patients with metastatic disease have a median survival time of 6-12 months. We recently demonstrated that the SAMMSON long non-co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c39d5f9289b2cc4cd46b12d1d8cded18
https://doi.org/10.1101/2021.09.29.462324
https://doi.org/10.1101/2021.09.29.462324