Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans.

Autor: Minniti ME; Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institute, Stockholm, Sweden., Pedrelli M; Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institute, Stockholm, Sweden., Vedin LL; Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institute, Stockholm, Sweden., Delbès AS; Unit of Functional and Adaptive Biology, Paris Diderot University, Sorbonne Paris Cité, Paris, France., Denis RGP; Unit of Functional and Adaptive Biology, Paris Diderot University, Sorbonne Paris Cité, Paris, France., Öörni K; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland., Sala C; Department of Physics and Astronomy, University of Bologna, Bologna, Italy., Pirazzini C; Institute of Neurological Sciences of Bologna, Bologna, Italy., Thiagarajan D; Department of Laboratory Medicine, Clinical Research Center, Karolinska Institute, Stockholm, Sweden., Nurmi HJ; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland.; Center of Excellence in Translational Cancer Biology, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland., Grompe M; Department of Pediatrics, Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR.; Yecuris Corporation, Tualatin, OR., Mills K; Center for Inborn Errors of Metabolism, University College London, London, UK., Garagnani P; Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institute, Stockholm, Sweden.; Department of Experimental, Diagnostic, and Specialty Medicine, and 'L. Galvani' Interdepartmental Research Center, University of Bologna, Bologna, Italy., Ellis ECS; Department of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden., Strom SC; Department of Laboratory Medicine, Division of Pathology, Karolinska Institute, Stockholm, Sweden., Luquet SH; Unit of Functional and Adaptive Biology, Paris Diderot University, Sorbonne Paris Cité, Paris, France., Wilson EM; Yecuris Corporation, Tualatin, OR., Bial J; Yecuris Corporation, Tualatin, OR., Steffensen KR; Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institute, Stockholm, Sweden., Parini P; Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institute, Stockholm, Sweden.; Department of Medicine, Metabolism Unit, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden.; Patient Area Nephrology and Endocrinology, Inflammation and Infection Theme, Karolinska University Hospital, Stockholm, Sweden.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2020 Aug; Vol. 72 (2), pp. 656-670. Date of Electronic Publication: 2020 Mar 23.