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Transcriptional and Metabolic Profiling of Nicotinamide-Enhanced Natural Killer (NAM-NK) Cells (GDA-201)

Publikováno v: Transplantation and Cellular Therapy. 28:S214-S215

Adoptive transfer of NK cells is a promising immunotherapeutic modality, however limited NK cell persistence and proliferation in vivo have historically been barriers to clinical success. Nicotinamide (NAM), an allosteric inhibitor of NAD-dependent e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5590b23fc199f599dbffa03824bdfcf7
https://doi.org/10.1016/s2666-6367(22)00427-4

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Enhanced In Vivo Persistence and Proliferation of NK Cells Expanded in Culture with the Small Molecule Nicotinamide: Development of a Clinical-Applicable Method for NK Expansion

Autor: Veronika Bachanova, Amnon Peled, Jeffrey S. Miller, Einat Galamidi, Chana Lador, Esti Olesinski, Tony Peled, Nurit Persi, Efrat Landau, Guy Brachya

Publikováno v: Blood. 130:657-657

Adoptive transfer of cytolitic Natural Killer (NK) cells is a promising immunotherapeutic modality for hematologic and other malignancies. However, limited NK cell in vivo persistence and proliferation have been challenging clinical success of this t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7ae8049fbea3b54d9fd48e87f8c8727
https://doi.org/10.1182/blood.v130.suppl_1.657.657

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Molecular analysis of transitional cell carcinoma using cDNA microarray

Autor: Aviv Regev, Ayelet Rahav, Lion Novak, Nurit Persi, Daniel Rothenstein, Avi Stein, Orna Mor, Yoel Shiboleth, Yoram Mor, Dana Lehavi, Leonid Brodsky, Ofer Nativ, Elena Feinstein, Rami Skaliter, Ada Rozen, Keren Morag, Eva Berent

Publikováno v: Oncogene. 22:7702-7710

The incidence of transitional cell carcinoma (TCC), the fourth most common neoplasm diagnosed in men, is rising. Despite the development of several noninvasive diagnostic tests, none have gained full recognition by the clinicians. Gene expression pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd271fd217b9ecfdd3c7ea534c2ed8a
https://doi.org/10.1038/sj.onc.1207039

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Improved Homing To Bone Marrow, Spleen and Lung Of Adoptively Infused NK Cells Expanded Ex Vivo With The Small Molecule Nicotinamide Using Feeder-Free Conditions

Autor: Amnon Peled, Richard W. Childs, Maria Berg, Toshihiro Onishi, Tony Peled, Nurit Persi, Chana Lador, Ritesh Kotecha, Robert Reger, Luis Espinoza-Calderon, Gabi M. Frei

Publikováno v: Blood. 122:897-897

Clinical results with NK cells in investigational tumor immunotherapy protocols have at best resulted in partial responses only. The inability of ex vivo expanded NK cells to proliferate in vivo, as well as to home to and be retained in the tumor mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0442f928c9d0373f27a0cb11f346dd85
https://doi.org/10.1182/blood.v122.21.897.897

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Nicotinamide, a Form of Vitamin B3, Promotes Expansion of Natural Killer Cells That Display Increased In Vivo Survival and Cytotoxic Activity

Autor: Nurit Persi, Chana Lador, Yael C Cohen, Tony Peled, Amnon Peled, Gabi M. Frei, Arnon Nagler

Publikováno v: Blood. 118:4035-4035

Abstract 4035 NK cells are cytotoxic lymphocytes that have drawn considerable attention in recent years as a promising tool for immunotherapy in patients with various refractory hematological malignancies and metastatic solid tumors. Clinical results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8ffb2698099008b0c0f3413c288799b
https://doi.org/10.1182/blood.v118.21.4035.4035

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