Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Nurit P Azouz"'
Autor:
Nurit P Azouz, Andrea Klingler, Victoria Callahan, Ivan Akhrymuk, Katarina Elez, Lluís Raich, Brandon Henry, Justin Benoit, Stefanie Benoit, Frank Noé, Kylene Kehn-Hall, Marc Rothenberg
Publikováno v:
Pathogens and Immunity, Vol 6, Iss 1 (2021)
Background: Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine prote
Externí odkaz:
https://doaj.org/article/02d7c92c7edd4daab794fc904a01876d
Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis
Autor:
Steven P. Proper, Alexander T. Dwyer, Andrews Appiagyei, Jennifer M. Felton, Netali Ben-Baruch Morgenstern, Justin M. Marlman, Michael Kotliar, Artem Barski, Ty D. Troutman, Marc E. Rothenberg, Tesfaye B. Mersha, Nurit P. Azouz
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
IntroductionAtopic dermatitis (AD) is an allergic skin disease mediated by skin barrier impairment and IL-13-driven immune response. Activation of the aryl hydrocarbon receptor (AHR) has shown promise in early clinical trials for AD; however, the mec
Externí odkaz:
https://doaj.org/article/250f10865655442983c6157c3f1b2cd5
Autor:
Nurit P. Azouz, Andrea M. Klingler, Mark Rochman, Misu Paul, Julie M. Caldwell, Michael Brusilovsky, Alexander T. Dwyer, Xiaoting Chen, Daniel Miller, Arthur Lynch, Carmy Forney, Leah C. Kottyan, Matthew T. Weirauch, Marc E. Rothenberg
Eosinophilic esophagitis (EoE) is a type 2 allergic disease characterized by esophageal inflammation and epithelial cell dysfunction. Acquired loss of the anti-serine protease of kazal type 7 (SPINK7) in the squamous epithelium of the esophagus has a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f0b71c007d0a0f3391cfb22d5bf4b83
https://doi.org/10.1101/2023.05.17.541192
https://doi.org/10.1101/2023.05.17.541192
Autor:
Kylene Kehn-Hall, Justin L. Benoit, Andrea M. Klingler, Marc E. Rothenberg, Katarina Elez, Lluís Raich, Ivan V. Akhrymuk, Brandon Michael Henry, Nurit P. Azouz, Victoria Callahan, Frank Noé, Stefanie W. Benoit
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 2
Pathogens and Immunity
article-version (status) pre
article-version (number) 2
Pathogens and Immunity
Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine protease 2 (TMPRS
Publikováno v:
Expert Review of Clinical Immunology. 16:421-428
Introduction: Diagnostic and therapeutic strategies in eosinophilic esophagitis (EoE) are constantly evolving. Recently, the improved understanding of EoE pathogenesis has led to identification of a variety of other potential targets that have never
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Allergic diseases (atopic dermatitis, food allergy, eosinophilic esophagitis, asthma and allergic rhinitis), perhaps more than many other traditionally grouped disorders, share several overlapping inflammatory pathways and risk factors, though we are
Autor:
Dong Hee Chung, Partha Karmakar, Michael A Tartell, Andrea M. Klingler, Vishnu C. Damalanka, Markus Hoffmann, Cassandra E Thompson, Sean P. J. Whelan, Matthew Mahoney, Stefan Pöhlmann, Paul W. Rothlauf, Melody Lee, Jorine Voss, Anthony J. O’Donoghue, André Luiz Lourenço, Charles S. Craik, Christina L. Stallings, Marc E. Rothenberg, James W. Janetka, Nurit P. Azouz, Anne E. Mayer Bridwell, Dustin Pwee, Lidija Klampfer
Publikováno v:
bioRxiv
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Proceedings of the National Academy of Sciences of the United States of America
Significance MM3122 represents an advanced lead candidate for clinical development as a novel antiviral drug for COVID-19. In addition to being novel drugs, these selective TMRSS2 inhibitors can be used as valuable chemical probes to help elucidate m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375bc698f0a068ad5bcd60e5bac8a49a
https://europepmc.org/articles/PMC8204910/
https://europepmc.org/articles/PMC8204910/
Publikováno v:
Journal of Clinical Investigation. 130:3419-3421
Allergic asthma is a chronic inflammatory lung disease associated with increased cytokine secretion. Aspects of airway inflammation are also linked to a common genetic variant that corresponds to the small GTPase, Rab27, a protein involved in vesicul
Autor:
Nurit P. Azouz, Marc E. Rothenberg
Publikováno v:
Journal of Clinical Investigation. 129:1419-1430
Gastrointestinal (GI) allergic disease is an umbrella term used to describe a variety of adverse, food antigen-driven, immune-mediated diseases. Although these diseases vary mechanistically, common elements include a breakdown of immunologic toleranc
Autor:
Marc E. Rothenberg, Markus Hoffmann, Nurit P. Azouz, Lluís Raich, Andrea M. Klingler, Tim Hempel, Simon Olsson, Stefan Pöhlmann, Frank Noé
Publikováno v:
Chemical Science
The entry of the coronavirus SARS-CoV-2 into human lung cells can be inhibited by the approved drugs camostat and nafamostat. Here we elucidate the molecular mechanism of these drugs by combining experiments and simulations. In vitro assays confirm t