Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia.

Autor: Andrés Dekanty, Nuria M Romero, Agustina P Bertolin, María G Thomas, Claudia C Leishman, Joel I Perez-Perri, Graciela L Boccaccio, Pablo Wappner

Publikováno v: PLoS Genetics, Vol 6, Iss 6, p e1000994 (2010)

Hypoxia-inducible factors (HIFs) are a family of evolutionary conserved alpha-beta heterodimeric transcription factors that induce a wide range of genes in response to low oxygen tension. Molecular mechanisms that mediate oxygen-dependent HIF regulat

Externí odkaz: https://doaj.org/article/77797d9c1feb40c79efdb23ea4dd140d

Timing the Juvenile-Adult Neurohormonal Transition: Functions and Evolution

Autor: Nuria M. Romero, Francisco A. Martín, Derya Deveci, Beatriz Gil-Marti, Celia G. Barredo

Publikováno v: Frontiers in Endocrinology, Vol 11 (2021)
Frontiers in Endocrinology

Puberty and metamorphosis are two major developmental transitions linked to the reproductive maturation. In mammals and vertebrates, the central brain acts as a gatekeeper, timing the developmental transition through the activation of a neuroendocrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128182c47fe84e9aed2008560f785c10

Growth and Maturation in Development: A Fly's Perspective

Autor: Nuria M. Romero, Renald Delanoue

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1260 (2020)
International Journal of Molecular Sciences, MDPI, 2020, 21 (4), pp.1260. ⟨10.3390/ijms21041260⟩
International Journal of Molecular Sciences, 2020, 21 (4), pp.1260. ⟨10.3390/ijms21041260⟩

In mammals like humans, adult fitness is improved due to resource allocation, investing energy in the developmental growth process during the juvenile period, and in reproduction at the adult stage. Therefore, the attainment of their target body heig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43411ff63d1ece980d1c2b66cb16f673
https://pubmed.ncbi.nlm.nih.gov/32070061

AstA Signaling Functions as an Evolutionary Conserved Mechanism Timing Juvenile to Adult Transition

Autor: Pierre Léopold, Nuria M. Romero, Derya Deveci, Francisco A. Martin

Publikováno v: Current Biology-CB
Current Biology-CB, 2019, 29 (5), pp.813-822.e4. ⟨10.1016/j.cub.2019.01.053⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Current Biology
Current Biology-CB, Elsevier, 2019, 29 (5), pp.813-822.e4. ⟨10.1016/j.cub.2019.01.053⟩

The onset of sexual maturation is the result of a hormonal cascade peaking with the production of steroid hormones. In animals undergoing a program of determinate growth, sexual maturation also coincides with the attainment of adult size. The exact s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98de4b728a3877e060e9b2796aba5e1b
https://hal.science/hal-02189162

Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability

Autor: Julien Colombani, Virginie Virolle, Michael J. Texada, Nuria M. Romero, Pierre Léopold, Ditte S. Andersen, Laura Boulan, Emilie Boone

Publikováno v: Current Biology-CB
Current Biology-CB, Elsevier, 2015, 25 (20), pp.2723-9
Current Biology

International audience; Early transplantation and grafting experiments suggest that body organs follow autonomous growth programs [1-3], therefore pointing to a need for coordination mechanisms to produce fit individuals with proper proportions. We r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8f852cb72da4e0ae99857e3eab1d3b
https://doi.org/10.1016/j.cub.2015.09.020