Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Nuria Lloberas"'
Autor:
Beatriz Fernández-Alarcón, Oscar Nolberger, Anna Vidal-Alabró, Raul Rigo-Bonnin, Josep M. Grinyó, Edoardo Melilli, Nuria Montero, Anna Manonelles, Ana Coloma, Alex Favà, Sergi Codina, Josep M. Cruzado, Helena Colom, Nuria Lloberas
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
AimsThe once-daily extended-release tacrolimus formulation (ER-Tac) has demonstrated similar efficacy and safety to the twice-daily immediate-release formulation (IR-Tac), but few population-based pharmacokinetic models have been developed in de novo
Externí odkaz:
https://doaj.org/article/e1e7a764787d4907916c5088a819c282
Autor:
Anna Vidal-Alabró, Helena Colom, Pere Fontova, Gema Cerezo, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Alex Favà, Josep M. Cruzado, Joan Torras, Josep M. Grinyó, Nuria Lloberas
Publikováno v:
Nefrología (English Edition), Vol 44, Iss 2, Pp 204-216 (2024)
Background and justification: The strategy of the concentration-dose (C/D) approach and the different profiles of tacrolimus (Tac) according to the cytochrome P450 polymorphisms (CYPs) focus on the metabolism of Tac and are proposed as tools for the
Externí odkaz:
https://doaj.org/article/080bb41af9964a478495db2667e29f1c
Autor:
Laura Martinez Valenzuela, Anna Vidal-Alabró, Belén Rubio, Paula Antón-Pàmpols, Francisco Gómez-Preciado, Xavier Fulladosa, Josep Maria Cruzado, Juan Torras, Nuria Lloberas, Juliana Draibe
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6479 (2024)
The inflammasome regulates the innate inflammatory response and is involved in autoimmune diseases. In this study, we explored the levels of IL-18 and IL-1β in serum and urine and the influence of various single-nucleotide polymorphisms (SNPs) on ki
Externí odkaz:
https://doaj.org/article/4ffe262b651e4742add7d897f292a447
Autor:
Zeyar Mohammed Ali, Marinda Meertens, Beatriz Fernández, Pere Fontova, Anna Vidal-Alabró, Raul Rigo-Bonnin, Edoardo Melilli, Josep M. Cruzado, Josep M. Grinyó, Helena Colom, Nuria Lloberas
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2699 (2023)
The aim of the study is to develop a population pharmacokinetic (PopPK) model and to investigate the influence of CYP3A5/CYP3A4 and ABCB1 single nucleotide polymorphisms (SNPs) on the Tacrolimus PK parameters after LCP-Tac formulation in stable adult
Externí odkaz:
https://doaj.org/article/9d949f15b70a4ab1b8f23ab50ab7990f
Autor:
Pere Fontova, Lisanne N. van Merendonk, Anna Vidal-Alabró, Raül Rigo-Bonnin, Gema Cerezo, Stefaan van Oevelen, Oriol Bestard, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Joan Torras, Josep M. Cruzado, Josep M. Grinyó, Helena Colom, Nuria Lloberas
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1481 (2023)
Despite intensive monitoring of whole blood tacrolimus concentrations, acute rejection after kidney transplantation occurs during tacrolimus therapy. Intracellular tacrolimus concentrations could better reflect exposure at the site of action and its
Externí odkaz:
https://doaj.org/article/17151f14f7b844a0abfe1718be0a1db2
Autor:
Elena Crespo, Anna Vidal-Alabró, Thomas Jouve, Pere Fontova, Maik Stein, Sonila Mocka, Maria Meneghini, Anett Sefrin, Petra Hruba, Montserrat Gomà, Alba Torija, Laura Donadeu, Alex Favà, Josep M. Cruzado, Edoardo Melilli, Francesc Moreso, Ondrej Viklicky, Frederike Bemelman, Petra Reinke, Josep Grinyó, Nuria Lloberas, Oriol Bestard
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Achieving fast immunosuppression blood exposure after kidney transplantation is key to abrogating both preformed and de novo anti-donor humoral and cellular alloresponses. However, while tacrolimus (TAC) is the cornerstone immunosuppressant inhibitin
Externí odkaz:
https://doaj.org/article/e1f40afe8ab94a93a922e44c70f720c5
Autor:
Maria Meneghini, Elena Crespo, Matthias Niemann, Alba Torija, Nuria Lloberas, Vincent Pernin, Pere Fontova, Edoardo Melilli, Alexandre Favà, Nuria Montero, Anna Manonelles, Josep Maria Cruzado, Eduard Palou, Jaume Martorell, Josep Maria Grinyó, Oriol Bestard
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Donor/recipient molecular human leukocyte antigen (HLA) mismatch predicts primary B-cell alloimmune activation, yet the impact on de novo donor-specific T-cell alloimmunity (dnDST) remains undetermined. The hypothesis of our study is that donor/recip
Externí odkaz:
https://doaj.org/article/ebaf9f1dcca14f848c8180699c05f2a0
Autor:
Pere Fontova, Helena Colom, Raül Rigo-Bonnin, Lisanne N. van Merendonk, Anna Vidal-Alabró, Nuria Montero, Edoardo Melilli, Maria Meneghini, Anna Manonelles, Josep M. Cruzado, Juan Torras, Josep Maria Grinyó, Oriol Bestard, Nuria Lloberas
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Introduction: Tacrolimus is the backbone immunosuppressant after solid organ transplantation. Tacrolimus has a narrow therapeutic window with large intra- and inter-patient pharmacokinetic variability leading to frequent over- and under-immunosuppres
Externí odkaz:
https://doaj.org/article/919fc8842deb4744a8f2acf7f43d07ac
Autor:
Jean-Baptiste Woillard, Michel Mourad, Michael Neely, Arnaud Capron, Ron H. van Schaik, Teun van Gelder, Nuria Lloberas, Dennis A. Hesselink, Pierre Marquet, Vincent Haufroid, Laure Elens
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacok
Externí odkaz:
https://doaj.org/article/3d7214df506f45e884e34c4182a984cf
Autor:
Ana Merino, Elia Ripoll, Laura De Ramon, Nuria Bolaños, Montserrat Goma, Oriol Bestard, Nuria Lloberas, Josep M. Grinyo, Juan Torras Ambròs
Publikováno v:
Cell Transplantation, Vol 26 (2017)
The immunomodulatory characteristics of mesenchymal stromal cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate, first, the effect of the donor-type MSCs from Wistar rats on t
Externí odkaz:
https://doaj.org/article/e4d25abca7c54b66a6ab7de7057ae6f3