Výsledky vyhledávání - "Nuria Gutierrez"

Akademický článek

Autor: Analía Goenaga, Nuria Gutierrez, Geraldina Bauer

Publikováno v: Proyecciones, Iss 18 (2024)

Resulta ineludible atender uno de los mayores problemas a los que se enfrenta la sociedad hoy, que es el cambio climático. Las organizaciones que generan altos niveles de emisiones de gases de efecto invernadero se ven inducidas a cambiar sus modelo

Externí odkaz: https://doaj.org/article/00d4b95751924d7190fe4b84c3d2a5dd

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Akademický článek

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Set for Variability as a Critical Predictor of Word Reading: Potential Implications for Early Identification and Treatment of Dyslexia

Autor: Laura Steacy, Ashley Edwards, Valeria Maria Rigobon, Nuria Gutierrez, Nancy Marencin, Noam Siegelman, Alexandra Himelhoch, Cristina Himelhoch, Jay Rueckl, Donald Compton

Quasiregular orthographies such as English contain substantial ambiguities between orthography and phonology that force developing readers to acquire flexibility during decoding of unfamiliar words, a skill referred to as a “set for variability”

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ebe380c3b146e13329110dd4c90020c
https://doi.org/10.31234/osf.io/syhxq

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DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

Autor: Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco

Publikováno v: Life Science Alliance. 5:e202101235

MAPK inhibitors (MAPKi) remain an important component of the standard of care for metastatic melanoma. However, acquired resistance to these drugs limits their therapeutic benefit. Tumor cells can become refractory to MAPKi by reactivation of ERK. Wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afa85adf8e2169721aa0b222025ddf6
https://doi.org/10.26508/lsa.202101235

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Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation

Autor: Antoni Riera, Craig Donoghue, Xavier Verdaguer, Angel R. Nebreda, Carolina Sanchez-Zarzalejo, Monica Cubillos-Rojas, Nuria Gutierrez-Prat

Publikováno v: European journal of medicinal chemistry. 201

We report the rational design of hetero-bifunctional small molecules that selectively target p38a and p38b for degradation These proteolysis targeted chimeras (PROTACs) are based on an ATP competitive inhibitor of p38a and p38b, which is linked to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0662b6e1e7c77c9e5ce660ed199a8067
https://pubmed.ncbi.nlm.nih.gov/32634680

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Requirement for epithelial p38α in KRAS-driven lung tumor progression

Autor: Alberto Villanueva, Angel R. Nebreda, Jessica Vitos-Faleato, Nuria Gutierrez-Prat, Sebastián M Real, Matthias Drosten, Elisabet Llonch, Mariano Barbacid

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Proc Natl Acad Sci U S A

Malignant transformation entails important changes in the control of cell proliferation through the rewiring of selected signaling pathways. Cancer cells then become very dependent on the proper function of those pathways, and their inhibition offers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838c618af67e0a1744bfd26beb07f81a
http://hdl.handle.net/2445/158000

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Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling

Autor: Elisabet Llonch, Angel R. Nebreda, Nuria Gutierrez-Prat, Lorena Gonzalez, Raquel Batlle, Eva Andrés, Antoni Berenguer-Llergo, Ana Igea

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)

The formation of new blood vessels is essential for normal development, tissue repair and tumor growth. Here we show that inhibition of the kinase p38α enhances angiogenesis in human and mouse colon tumors. Mesenchymal cells can contribute to tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db43aca09ee92a7ad13ea97226aa5306
http://europepmc.org/articles/PMC6624205

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Radiomics textural features extracted from subcortical structures of Gray matter probability for Alzheimers disease detection

Autor: Roberto Garrido Garcia, Alejandro Rodríguez González, Cesar Antonio Ortiz Toro, Consuelo Gonzalo-Martin, Ernestina Menasalvas Ruiz, Nuria Gutierrez Sanchez

Publikováno v: EEE 32nd International Symposium on Computer-Based Medical Systems (CBMS), 2019 | 2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS) | 5-7 June 2019 | Cordoba, España
Archivo Digital UPM
Universidad Politécnica de Madrid
CBMS

Alzheimer’s disease (AD) is characterized by a progressive deterioration of cognitive and behavioural functions as a result of the atrophy of specific regions of the brain. It is estimated that by 2050 there will be 131.5 million people affected. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630c4a14887c74a67dc3844385a8005d

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Akademický článek

Identifying Preservice Teachers’ Belief Profiles and their Performance in a Web-based Training for Writing Instruction

Autor: Rocío C. Seoane, Juan E. Jiménez, Nuria Gutiérrez

Publikováno v: Psicología Educativa: Revista de los Psicólogos de la Educación, Vol 29, Iss 2, Pp 121-132 (2023)

This research aims to fill the need to provide writing education to preservice teachers by using web-based instruction. The novel contribution of this work lies in the consideration of beliefs as a methodological prerequisite when measuring the effec

Externí odkaz: https://doaj.org/article/1b791a328dbb4f75a084e2324a5cb270

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