Výsledky vyhledávání - "Nuria Assa-Munt"

Analysis of Apoptosis Protein Expression in Early-Stage Colorectal Cancer Suggests Opportunities for New Prognostic Biomarkers

Autor: Michelle M Tsukamoto, Nuria Assa-Munt, John C. Reed, Zhe Piao, Chul Kim, M Krajewska, Shu-ichi Matsuzawa, Kate Welsh, Hoguen Kim, Koichi Suzuki, Haeyoun Kang, Stan Krajewski, Manuel Perucho, Ronald G. Thomas

Publikováno v: Clinical Cancer Research. 11:5451-5461

Purpose: Although most stage II colon cancers are potentially curable by surgery alone, ∼20% of patients relapse, suggesting a need for establishing prognostic markers that can identify patients who may benefit from adjuvant chemotherapy. We tested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72341ee2131143f8bcc1ebf42ad65d7f
https://doi.org/10.1158/1078-0432.ccr-05-0094

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Selection and Structure of Ion-selective Ligands for Platelet Integrin αIIbβ3

Autor: Jeffrey W. Smith, Hervé Le Calvez, Nicholas E. Preece, Nuria Assa-Munt, Xin Jia, Lilian Parra-Gessert

Publikováno v: Journal of Biological Chemistry. 277:10298-10305

Integrins contain a number of divalent cation binding sites that control ligand binding affinity. Ions such as Ca(2+) and Mg(2+) bind to distinct sites on integrin and can have opposing effects on ligand binding. These effects are presumably brought

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https://doi.org/10.1074/jbc.m108071200

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Dimerization-dependent block of the proapoptotic effect of P75NTR

Autor: Shahrooz Rabizadeh, Andrea Tasinato, Sabina Sperandio, David M. Spencer, Dale E. Bredesen, Michael Green, Nuria Assa-Munt, James Wang, Xin Ye

Publikováno v: Journal of Neuroscience Research. 60:587-593

The biochemical mechanism by which neurons become dependent on neurotrophins for survival is unknown. We found previously that the common neurotrophin receptor, p75NTR, is a mediator of neurotrophin dependence and that this effect requires a novel ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b11777c07535aa243391e5c73fc86d
https://doi.org/10.1002/(sici)1097-4547(20000601)60:5<587::aid-jnr3>3.0.co

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Backbone dynamics of a short PU.1 ETS domain 1 1Edited by P. E. Wright

Autor: Xin Jia, James Light, Larry K. Lee, Arthur G. Palmer, Nuria Assa-Munt

Publikováno v: Journal of Molecular Biology. 292:1083-1093

The resonance assignments, secondary structure and backbone dynamics of the ETS domain of the transcription factor PU.1 have been determined for the free protein in solution by NMR spectroscopy. The secondary structure for the free ETS domain is simi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcacea4dc6104d61a4f29e7e4fa7eb30
https://doi.org/10.1006/jmbi.1999.3123

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Mutants of ETS domain PU.1 and GGAA/T recognition: Free energies and kinetics

Autor: Juan Yguerabide, Richard A. Maki, Nuria Assa-Munt, Frederic Pio

Publikováno v: Protein Science. 8:2098-2109

The ETS family members display specific DNA binding site preferences. As an example, PU.1 and ETS-1 recognize different DNA sequences with a core element centered over 5'-GGAA-3' and 5'-GGAA/T-3', respectively. To understand the molecular basis of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe0a375228bb2771de32d9b0c1ba59c
https://doi.org/10.1110/ps.8.10.2098

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Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation

Autor: David W. Rose, Nuria Assa-Munt, Joseph Torchia, Michael V. Milburn, Tina-Marie Mullen, Stefan Westin, Anna Krones, Michael G. Rosenfeld, Robert T. Nolte, Eileen M. McInerney, Juan Inostroza, Sarah E. Flynn, Christopher K. Glass

Publikováno v: Genes & Development. 12:3357-3368

Ligand-dependent activation of gene transcription by nuclear receptors is dependent on the recruitment of coactivators, including a family of related NCoA/SRC factors, via a region containing three helical domains sharing an LXXLL core consensus sequ

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https://doi.org/10.1101/gad.12.21.3357

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p75NTR and the concept of cellular dependence: seeing how the other half die

Autor: Shahrooz Rabizadeh, Nuria Assa-Munt, Andrea Tasinato, Sabina Sperandio, Xin Ye, James Wang, Dale E. Bredesen

Publikováno v: Cell Death & Differentiation. 5:365-371

Cells depend on specific stimuli, such as trophic factors, for survival and in the absence of such stimuli, undergo apoptosis. How do cells initiate apoptosis in response to the withdrawal of trophic factors or other dependent stimuli? Recent studies

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https://doi.org/10.1038/sj.cdd.4400378

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A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

Autor: John C. Reed, Kate Welsh, Quinn Deveraux, Ryosuke Takahashi, Guy S. Salvesen, Ingo Tamm, Nuria Assa-Munt

Publikováno v: Journal of Biological Chemistry. 273:7787-7790

The inhibitor of apoptosis proteins (IAPs) constitute an evolutionarily conserved family of homologous proteins that suppress apoptosis induced by multiple stimuli. Some IAP family proteins, including XIAP, cIAP-1, and cIAP-2, can bind and directly i

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https://doi.org/10.1074/jbc.273.14.7787

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A cytoplasmic peptide of the neurotrophin receptor p75NTR: induction of apoptosis and NMR determined helical conformation

Autor: Shahrooz Rabizadeh, Dale E. Bredesen, Barbara S. Chapman, Nuria Assa-Munt, Leigh A. Plesniak, Viswanathan V Krishnan, Matthew R. Hileman

Publikováno v: FEBS Letters. 415:145-154

The neurotrophin receptor (NTR) and tumor necrosis factor receptor family of receptors regulate apoptotic cell death during development and in adult tissues [Beutler and van Huffel, Science 264 (1994) 667–668]. We have examined a fragment of p75NTR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fe4dc42e31c00903c03dbdcd097ab4
https://doi.org/10.1016/s0014-5793(97)01113-7

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Solution conformation of an immunogenic peptide derived from the principal neutralizing determinant of the HIV-2 envelope glycoprotein gp125

Autor: Nuria Assa-Munt, Erling Norrby, Brian D. Sykes, A. Patricia Campbell, H. Jane Dyson

Publikováno v: Scopus-Elsevier

Backgound: The conformational preferences of a number of peptides with sequences related to the envelope glycoproteins of HIV-1 have been investigated in the past few years. Similar studies have not been made for HIV-2, which is a distinct virus with

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https://doi.org/10.1016/s1359-0278(96)00024-7

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