Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nuria A. Tamayo"'
Autor:
Brian Belmontes, Jodi Moriguchi, Grace Chung, Jan Sun, Maria Stefania S. Ninniri, Kelly Hanestad, Kui Chen, John D. McCarter, Upendra P. Dahal, Sudipa Ghimire-Rijal, Yue Hao, Christopher P. Mohr, Xinchao Yu, Matthew G. Rees, Melissa Ronan, Jennifer Roth, Sheroy Minocherhomji, Jennifer R. Allen, Matthew P. Bourbeau, Paul E. Hughes, Nuria A Tamayo, Marc N. Payton
Publikováno v:
Cancer Research. 83:516-516
Chromosomal instability (CIN) is a hallmark of human cancers and is caused by persistent errors in chromosome segregation during mitosis. Aggressive types of human cancer such as high-grade serous ovarian cancer and triple-negative breast cancer have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35caf28e90cc86d95a85ee0af8c0a54
https://doi.org/10.1158/1538-7445.am2023-516
https://doi.org/10.1158/1538-7445.am2023-516
Autor:
Nuria A. Tamayo, Matthew P. Bourbeau, Jennifer R. Allen, Kate S. Ashton, Jian Jeffrey Chen, Matthew R. Kaller, Thomas T. Nguyen, Nobuko Nishimura, Liping H. Pettus, Mary Walton, Brian Belmontes, Jodi Moriguchi, Kui Chen, John D. McCarter, Kelly Hanestad, Grace Chung, Maria Stefania S. Ninniri, Jan Sun, Leszek Poppe, Chris Spahr, John Hui, Lei Jia, Tian Wu, Upendra P. Dahal, Katheryne Z. Edson, Marc Payton
Publikováno v:
Journal of medicinal chemistry. 65(6)
Chromosomal instability (CIN) is a hallmark of cancer that results from errors in chromosome segregation during mitosis. Targeting of CIN-associated vulnerabilities is an emerging therapeutic strategy in drug development. KIF18A, a mitotic kinesin, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b073c07dd2504a104516bc02d88ed4
https://pubmed.ncbi.nlm.nih.gov/35286090
https://pubmed.ncbi.nlm.nih.gov/35286090
Autor:
Brian A. Lanman, Jennifer R. Allen, John G. Allen, Albert K. Amegadzie, Kate S. Ashton, Shon K. Booker, Jian Jeffrey Chen, Ning Chen, Michael J. Frohn, Guy Goodman, David J. Kopecky, Longbin Liu, Patricia Lopez, Jonathan D. Low, Vu Ma, Ana E. Minatti, Thomas T. Nguyen, Nobuko Nishimura, Alexander J. Pickrell, Anthony B. Reed, Youngsook Shin, Aaron C. Siegmund, Nuria A. Tamayo, Christopher M. Tegley, Mary C. Walton, Hui-Ling Wang, Ryan P. Wurz, May Xue, Kevin C. Yang, Pragathi Achanta, Michael D. Bartberger, Jude Canon, L. Steven Hollis, John D. McCarter, Christopher Mohr, Karen Rex, Anne Y. Saiki, Tisha San Miguel, Laurie P. Volak, Kevin H. Wang, Douglas A. Whittington, Stephan G. Zech, J. Russell Lipford, Victor J. Cee
Publikováno v:
Journal of Medicinal Chemistry. 63:52-65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d131821132bab6ea5628a8639f9d9435
https://doi.org/10.1021/acs.jmedchem.9b01180
https://doi.org/10.1021/acs.jmedchem.9b01180
Autor:
Heather Eastwood, Andrew Tasker, Yuping Chen, David Powers, Nadia Guerrero, Christopher Mohr, Anthony B. Reed, Jimmy Laszlo, Paul Wang, Yihong Zhou, Ryan Wurz, Mark H. Norman, Karen Rex, Jeffrey T. Winston, Liping H. Pettus, Dean Hickman, Yang Xu, Brian A. Lanman, Tian Wu, Yen Nguyen, Kristin L. Andrews, J. Russell Lipford, Frank Chavez, Hui-Ling Wang, Christine Sastri, Matthew R. Lee, Bethany Mattson, Nuria A. Tamayo, Victor J. Cee, Jie Chen, Bradley J. Herberich, Bin Wu, Shon Booker
Publikováno v:
Journal of Medicinal Chemistry. 59:6407-6430
The high expression of proviral insertion site of Moloney murine leukemia virus kinases (Pim-1, -2, and -3) in cancers, particularly the hematopoietic malignancies, is believed to play a role in promoting cell survival and proliferation while suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f85b2099ac31a14dc5abf0c6c20c999
https://doi.org/10.1021/acs.jmedchem.6b00610
https://doi.org/10.1021/acs.jmedchem.6b00610
Autor:
Kevin Yang, Rod Cupples, Gwyneth Van, Nobuko Nishimura, Longbin Liu, David J. St. Jean, Clarence Hale, Glenn Sivits, Jie Chen, Nuria A. Tamayo, Steven R. Jordan, Fang-Tsao Hong, Mark H. Norman, Michael D. Bartberger, Yunxin Bo, Christopher H. Fotsch, Samer Chmait, Seifu Tadesse, David Lloyd
Publikováno v:
Journal of Medicinal Chemistry. 58:4462-4482
The glucokinase-glucokinase regulatory protein (GK-GKRP) complex plays an important role in controlling glucose homeostasis in the liver. We have recently disclosed a series of arylpiperazines as in vitro and in vivo disruptors of the GK-GKRP complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0067ff276fb22038ac064d47a32d35c8
https://doi.org/10.1021/jm5018175
https://doi.org/10.1021/jm5018175
Autor:
Bradley J. Herberich, Tian Wu, Paul E. Hughes, Claire L. M. Jackson, Nobuko Nishimura, Nancy Zhang, Ryan Wurz, Douglas A. Whittington, Shon Booker, Sean Caenepeel, Tisha San Miguel, Jian Jiang, Anthony B. Reed, Adrian L. Smith, Seifu Tadesse, Brian A. Lanman, Andrew Tasker, Erin L. Mullady, John D. McCarter, Fang-Tsao Hong, Liping H. Pettus, Divesh Aidasani, Victor J. Cee, Ling Wang, Bin Wu, Mark H. Norman, Daniel J. Freeman, Kevin Yang, Longbin Liu, Leeanne Zalameda, Yunxin Y. Bo, Xiaochun Zhu, Kristin L. Andrews, Markian Stec, Nuria A. Tamayo, Raju Subramanian, Noel D'angelo
Publikováno v:
Journal of Medicinal Chemistry. 55:7796-7816
The phosphoinositide 3-kinase family catalyzes the phosphorylation of phosphatidylinositol-4,5-diphosphate to phosphatidylinositol-3,4,5-triphosphate, a secondary messenger which plays a critical role in important cellular functions such as metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7379e5002efb24d810fb0e1f33a3641
https://doi.org/10.1021/jm300846z
https://doi.org/10.1021/jm300846z
Autor:
Yunxin Y. Bo, Leeanne Zalameda, Kevin Yang, Fang-Tsao Hong, Longbin Liu, Anthony B. Reed, Kristin L. Andrews, Tisha San Miguel, Brian A. Lanman, Paul E. Hughes, Noel D'angelo, Brad Herberich, Jian Jiang, Victor J. Cee, Claire L. M. Jackson, Ryan Wurz, Nobuko Nishimura, Raju Subramanian, Seifu Tadesse, Nancy Zhang, John D. McCarter, Daniel J. Freeman, Ling Wang, Nuria A. Tamayo, Erin L. Mullady, Mark H. Norman, Liping H. Pettus, Tian Wu, Douglas A. Whittington, Sean Caenepeel, Adrian L. Smith, Shon Booker
Publikováno v:
Journal of Medicinal Chemistry. 55:5188-5219
A highly selective series of inhibitors of the class I phosphatidylinositol 3-kinases (PI3Ks) has been designed and synthesized. Starting from the dual PI3K/mTOR inhibitor 5, a structure-based approach was used to improve potency and selectivity, res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e14c947647f0ff5c20164ffa4566dd
https://doi.org/10.1021/jm300184s
https://doi.org/10.1021/jm300184s
Autor:
Sonya G. Lehto, Weiya Wang, Narender R. Gavva, Hong Deng, Mark H. Norman, Lana Klionsky, Nobuko Nishimura, Brad Youngblood, Phi Tang, Vu Van Ma, Jiyun Chen, Vijay Keshav Gore, Michael D. Bartberger, Nuria A. Tamayo, Tiffany L. Correll, Yunxin Bo
Publikováno v:
Journal of Medicinal Chemistry. 55:1593-1611
The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation channel primarily expressed in a subpopulation of sensory neurons that can be activated by a wide range of stimuli, including menthol, icilin, and cold temperatures (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1beaabfc08eed8ea8dfb711873a8ed34
https://doi.org/10.1021/jm2013634
https://doi.org/10.1021/jm2013634
Autor:
Kristin L. Andrews, Kevin Yang, Markian Stec, Tisha San Miguel, Ling Wang, John McCarter, Mark H. Norman, Shon Booker, Jian Jiang, Nan Zhang, Daniel J. Freeman, Erin L. Mullady, Hongyu Liao, Paul E. Hughes, Leeanne Zalameda, Sean Caenepeel, Raju Subramanian, Nuria A. Tamayo
Publikováno v:
Journal of Medicinal Chemistry. 54:5174-5184
N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide (1) is a potent and efficacious inhibitor of PI3Kα and mTOR in vitro and in vivo. However, in hepatocyte and in vivo metabolism studies, 1 was found to undergo d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a9feddc793ad895a56aaf047e435fd
https://doi.org/10.1021/jm2004442
https://doi.org/10.1021/jm2004442
Autor:
Ling Wang, Leeanne Zalameda, Hongyu Liao, Kristin L. Andrews, Yunxin Bo, Nobuko Nishimura, Paul E. Hughes, John D. McCarter, Erin L. Mullady, Tisha San Miguel, Douglas A. Whittington, Sean Caenepeel, Nancy Zhang, Daniel J. Freeman, Mark H. Norman, Shon Booker, Aaron C. Siegmund, Nuria A. Tamayo, Marian C. Bryan, Raju Subramanian, Kevin Yang, Longbin Liu
Publikováno v:
Journal of Medicinal Chemistry. 54:4735-4751
The phosphoinositide 3-kinase (PI3K) family catalyzes the ATP-dependent phosphorylation of the 3'-hydroxyl group of phosphatidylinositols and plays an important role in cell growth and survival. There is abundant evidence demonstrating that PI3K sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d51bb8cdaf63d264b7bb9e0cbc6de70
https://doi.org/10.1021/jm200386s
https://doi.org/10.1021/jm200386s