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Akademický článek

Lung adenocarcinoma presenting with eosinophilic erythroderma associated with anti‐KRT6B antibodies: Case report

Autor: Nihan Erden, Saba Khoshbakht, Arda Yaycioglu, Ali Kizilirmak, Özgecan Kayalar, Cüyan Demirkesen, Ibrahim Kulaç, Nazlı Ezgi Özkan Küçük, Nurhan Ozlu, Thomas Ruzicka, Andreas Wollenberg, Seçil Vural

Publikováno v: JEADV Clinical Practice, Vol 2, Iss 2, Pp 351-355 (2023)

Abstract Paraneoplastic erythroderma (PE) is a rare and potentially life‐threatening inflammatory condition associated with malignancy. PE may potentially develop due to antibodies produced against tumoral antigens that cross‐react with epidermal

Externí odkaz: https://doaj.org/article/15b09b13a9334b0191566b7c00340422

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Akademický článek

Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Cryptochromes are transcriptional regulators of the circadian clock in mammals, and genetic loss of cryptochromes reduces p53-associated cancer risk in mice. Here the authors report the discovery of small molecule M47, which destabilizes cryptochrome

Externí odkaz: https://doaj.org/article/74ebf0d9b13b4f24b201b187236a7cc6

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Data from Quantitative Proteomics Identifies Secreted Diagnostic Biomarkers as well as Tumor-Dependent Prognostic Targets for Clear Cell Renal Cell Carcinoma

Autor: Nurhan Ozlu, Nurcan Tuncbag, Tarik Esen, Sidar Bagbudar, Selcuk Erdem, Omer Acar, Murat C. Kiremit, Ayse Armutlu, Ayse T. Sahin, Aydanur Senturk

Clear cell renal cell carcinoma (ccRCC) is the third most common and most malignant urological cancer, with a 5-year survival rate of 10% for patients with advanced tumors. Here, we identified 10,160 unique proteins by in-depth quantitative proteomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2cffc9c4df93e35249a6d61602076aa
https://doi.org/10.1158/1541-7786.c.6545342.v1

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Proteome analysis of the circadian clock protein PERIOD2

Autor: Huseyin Gul, Saba Selvi, Fatma Yilmaz, Gozde Ozcelik, Senanur Olfaz‐Aslan, Seyma Yazan, Busra Tiryaki, Seref Gul, Ali Yurtseven, Ibrahim Halil Kavakli, Nurhan Ozlu, Nuri Ozturk

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 90:1315-1330

Circadian rhythms are a series of endogenous autonomous 24-h oscillations generated by the circadian clock. At the molecular level, the circadian clock is based on a transcription-translation feedback loop, in which BMAL1 and CLOCK transcription fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cab20725e73fc691b4be6717fb3a6c5
https://doi.org/10.1002/prot.26314

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Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis

Autor: Nazlı Ezgi Özkan, Berfu Nur Yigit, Beste Senem Degirmenci, Mohammad Haroon Qureshi, Gamze Nur Yapici, Altuğ Kamacıoglu, Nima Bavili, Alper Kiraz, Nurhan Ozlu

Publikováno v: Journal of Cell Science. 136

Cell division requires dramatic reorganization of the cell cortex, which is primarily driven by the actomyosin network. We previously reported that protocadherin 7 (PCDH7) gets enriched at the cell surface during mitosis, which is required to build u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60c5fb895b621667aa4e8e7be8e0477f
https://doi.org/10.1242/jcs.260266

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Aurora B Kinase Dependent Phosphorylation of Keratin 8 is required for Cytokinesis in Mammalian Cells of Epithelial Origin

Autor: Busra Harmanda, Oyku Kaya, Xenia Waide, Muhammed Haroon Qureshi, Alexey Nesvizhskii, Timothy J Mitchison, Nurhan Ozlu

Keratins are the most diverse family of intermediate filaments and are expressed in most epithelial tissues and malignancies. They form highly stable polymers that need to be cut through during cytokinesis. Previous work suggested a role of phosphory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1d924d8441b74253797edf65202014a
https://doi.org/10.1101/2023.01.22.525045

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Quantitative phosphoproteomics analysis uncovers PAK2 and CDK1 mediated malignant signaling pathways in clear cell Renal Cell Carcinoma

Autor: Aydanur Senturk, Ayse T. Sahin, Ayse Armutlu, Murat Can Kiremit, Omer Acar, Selcuk Erdem, Sidar Bagbudar, Tarik Esen, Nurhan Ozlu

Publikováno v: Molecular and Cellular Proteomics

Clear cell Renal Cell Carcinoma (ccRCC) is among the 10 most common cancers in both men and women and causes more than 140,000 deaths worldwide every year. In order to elucidate the underlying molecular mechanisms orchestrated by phosphorylation modi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd879721710407adb370c0a9eb2a860
http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10862

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Reticulon-like REEP4 at the inner nuclear membrane promotes nuclear pore complex formation

Autor: Banafsheh Golchoubian, Andreas Brunner, Helena Bragulat-Teixidor, Annett Neuner, Busra A. Akarlar, Nurhan Ozlu, Anne-Lore Schlaitz

Publikováno v: Journal of Cell Biology (JCB)

Nuclear pore complexes (NPCs) are channels within the nuclear envelope that mediate nucleocytoplasmic transport. NPCs form within the closed nuclear envelope during interphase or assemble concomitantly with nuclear envelope reformation in late stages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5456a2f186478c74b4942464994b8971
https://doi.org/10.1083/jcb.202101049

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