Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Nurdan Akogul"'
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Akademický článek
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
Autor: Tim van Groningen, Nurdan Akogul, Ellen M. Westerhout, Alvin Chan, Nancy E. Hasselt, Danny A. Zwijnenburg, Marloes Broekmans, Peter Stroeken, Franciska Haneveld, Gerrit K. J. Hooijer, C. Dilara Savci-Heijink, Arjan Lakeman, Richard Volckmann, Peter van Sluis, Linda J. Valentijn, Jan Koster, Rogier Versteeg, Johan van Nes
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Neuroblastoma includes adrenergic and mesenchymal cell types that can interconvert. Here, the authors show that this transdifferentiation is driven by a NOTCH feedforward loop that allows a swift transition between two semi-stable cellular states.
Externí odkaz: https://doaj.org/article/514276fb271e42e0afc3df43c40d7742
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4
Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Autor: Linda J. Valentijn, Ellen M. Westerhout, Rogier Versteeg, Alvin Chan, Arjan Lakeman, Peter van Sluis, Natalia E Nowakowska, Mohamed Hamdi, Igor Adameyko, Nancy E. Hasselt, Boris Bleijlevens, Tim van Groningen, Franciska Haneveld, Jan Koster, Carel J. M. van Noesel, Nurdan Akogul, Richard Volckmann, Peter Stroeken, Danny A. Zwijnenburg, Jennemiek van Arkel, Johan van Nes
Publikováno v: Cancer research, 82(3), 484-496. American Association for Cancer Research Inc.
Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed adrenergic (ADRN) or an i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8eca38a6b36d94471b13429c50ac12
http://www.scopus.com/inward/record.url?scp=85124056607&partnerID=8YFLogxK
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7
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
Autor: Richard Volckmann, Ellen M. Westerhout, C. Dilara Savci-Heijink, Alvin Chan, Tim van Groningen, Gerrit K. J. Hooijer, Linda J. Valentijn, Franciska Haneveld, Peter Stroeken, Arjan Lakeman, Jan Koster, Johan van Nes, Nancy E. Hasselt, Danny A. Zwijnenburg, Marloes Broekmans, Peter van Sluis, Nurdan Akogul, Rogier Versteeg
Publikováno v: Nature communications, 10(1):1530. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Transition between differentiation states in development occurs swift but the mechanisms leading to epigenetic and transcriptional reprogramming are poorly understood. The pediatric cancer neuroblastoma includes adrenergic (ADRN) and mesenchymal (MES
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f46c8e4e72477cacc07720f2f7cbe7
https://doi.org/10.1038/s41467-019-09470-w
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8
Neuroblastoma is composed of two super-enhancer-associated differentiation states
Autor: Bart A. Westerman, Rogier Versteeg, Arjan Lakeman, Johannes Bras, Peter van Sluis, Aldo Jongejan, Frank Baas, Antoine H. C. van Kampen, Jan J. Molenaar, Linda Koster, Margriet Huizer-Smit, Carel J. M. van Noesel, Nancy E. Hasselt, Danny A. Zwijnenburg, Lianne van Dijk-Kerkhoven, Marloes Broekmans, Mohamed Hamdi, Richard Volckmann, Tim van Groningen, Godelieve A.M. Tytgat, Franciska Haneveld, Natalia E Nowakowska, Linda J. Valentijn, Jan Koster, Nurdan Akogul, Piet Molenaar, Maria C. Lecca, Ellen M. Westerhout, Alvin Chan, Johan van Nes, Marli E. Ebus
Publikováno v: Nature Genetics, 49(8), 1261
Nature Genetics, 49(8), 1261-1266. Nature Publishing Group
Van Groningen, T, Koster, J, Valentijn, L J, Zwijnenburg, D A, Akogul, N, Hasselt, N E, Broekmans, M, Haneveld, F, Nowakowska, N E, Bras, J, Van Noesel, C J M, Jongejan, A, Van Kampen, A H, Koster, L, Baas, F, Van Dijk-Kerkhoven, L, Huizer-Smit, M, Lecca, M C, Chan, A, Lakeman, A, Molenaar, P, Volckmann, R, Westerhout, E M, Hamdi, M, Van Sluis, P G, Ebus, M E, Molenaar, J J, Tytgat, G A, Westerman, B A, Van Nes, J & Versteeg, R 2017, ' Neuroblastoma is composed of two super-enhancer-associated differentiation states ', Nature Genetics, vol. 49, no. 8, pp. 1261-1266 . https://doi.org/10.1038/ng.3899
Nature genetics, 49(8), 1261-1266. Nature Publishing Group
Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has sparked an interest in their epigenetic regulation. Several tumor types include phenotypically divergent cells, resembling cells from different lineage development s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f05e663859e4d514b96ffa508717332
https://doi.org/10.1038/ng.3899
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