Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy

Autor: Nur Mehpare Kocaturk, Nesibe Peker, Karin Eberhart, Yunus Akkoc, Gamze Deveci, Joern Dengjel, Devrim Gozuacik

Publikováno v: Cell Death and Disease, Vol 13, Iss 11, Pp 1-15 (2022)

Abstract Autophagy is an evolutionarily conserved eukaryotic cellular mechanism through which cytosolic fragments, misfolded/aggregated proteins and organelles are degraded and recycled. Priming of mitochondria through ubiquitylation is required for

Externí odkaz: https://doaj.org/article/4c0b871a164c40d997c2cd1c55e069a3

Bi-allelic mutations in uncoordinated mutant number-45 myosin chaperone B are a cause for congenital myopathy

Autor: Hormos Salimi Dafsari, Nur Mehpare Kocaturk, Hülya-Sevcan Daimagüler, Anna Brunn, Jörg Dötsch, Joachim Weis, Martina Deckert, Sebahattin Cirak

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-5 (2019)

Abstract Congenital myopathies (CM) form a genetically heterogeneous group of disorders characterized by perinatal muscle weakness. Here, we report an 11-year old male offspring of consanguineous parents of Lebanese origin. He presented with proximal

Externí odkaz: https://doaj.org/article/772b453f3d4b44bca52d1245facc463d

IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation.

Autor: Oznur Bayraktar, Ozlem Oral, Nur Mehpare Kocaturk, Yunus Akkoc, Karin Eberhart, Ali Kosar, Devrim Gozuacik

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164864 (2016)

The ubiquitin-proteasome system (UPS) degrades soluble proteins and small aggregates, whereas macroautophagy (autophagy herein) eliminates larger protein aggregates, tangles and even whole organelles in a lysosome-dependent manner. VCP/p97 was implic

Externí odkaz: https://doaj.org/article/9e25664575e942fab4be1c9a13771abc

Inertial focusing of cancer cell lines in curvilinear microchannels

Autor: Ali Koşar, Mehrdad Karimzadehkhouei, Ozlem Kutlu, Seçil Erbil Bilir, Nur Mehpare Kocaturk, Arzu Özbey, Devrim Gozuacik

Publikováno v: Micro and Nano Engineering, Vol 2, Iss, Pp 53-63 (2019)

Circulating tumor cells (CTCs) are rare cancer cells, which originate from the primary tumors and migrate to the bloodstream. Separation of CTCs from blood is critical because metastatic CTCs might hold different genomic and phenotypic properties com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de193160ea4c61848311de7f39dd6533
https://doi.org/10.1016/j.mne.2019.01.002

Bi-allelic mutations in uncoordinated mutant number-45 myosin chaperone B are a cause for congenital myopathy

Autor: Joachim Weis, Anna Brunn, Nur Mehpare Kocaturk, Hülya-Sevcan Daimagüler, Jörg Dötsch, Martina Deckert, Sebahattin Cirak, Hormos Salimi Dafsari

Publikováno v: Acta Neuropathologica Communications 7(1), 211 (2019). doi:10.1186/s40478-019-0869-1
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-5 (2019)
Acta Neuropathologica Communications

Acta Neuropathologica Communications 7(1), 211 (2019). doi:10.1186/s40478-019-0869-1
Published by Biomed Central, London

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b10be31ff9d0a69204f920f2474256
https://publications.rwth-aachen.de/record/782617