Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nur Bruss"'
Autor:
Elana Thieme, Nur Bruss, Duanchen Sun, Edward C. Dominguez, Daniel Coleman, Tingting Liu, Carly Roleder, Melissa Martinez, Krystine Garcia-Mansfield, Brian Ball, Patrick Pirrotte, Lili Wang, Zheng Xia, Alexey V. Danilov
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-17 (2023)
Abstract Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which contributes to drug resistance, necessitating development of novel therapeutic approaches. Pharmacological inhibitors of cyclin-dependent kinases (CDK) de
Externí odkaz:
https://doaj.org/article/2ef2e1767bf742bb916cefc948518a5f
Autor:
Elana Thieme, Tingting Liu, Nur Bruss, Carly Roleder, Vi Lam, Xiaoguang Wang, Tamilla Nechiporuk, Geoffrey Shouse, Olga V. Danilova, Daniel Bottomly, Shannon K. McWeeney, Jeffrey W. Tyner, Stephen E. Kurtz, Alexey V. Danilov
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-11 (2022)
Abstract Aberrant B-cell receptor (BCR) signaling is a key driver in lymphoid malignancies. Bruton tyrosine kinase (BTK) inhibitors that disrupt BCR signaling have received regulatory approvals in therapy of mantle cell lymphoma (MCL). However, respo
Externí odkaz:
https://doaj.org/article/6ba6538ef93547b086ba5fe9d9f53329
Autor:
Alexey V. Danilov, Peter Hurlin, Justin Cidado, Lisa Drew, Prabhjot Kaur, Craig Y. Okada, Erin W. Gilbert, Joelle Wolf, Cody J. Paiva, Olga Danilova, Vi Lam, Scott Best, Nur Bruss, Taylor Hashiguchi
Deregulation of the MYC transcription factor is a key driver in lymphomagenesis. MYC induces global changes in gene expression that contribute to cell growth, proliferation, and oncogenesis by stimulating the activity of RNA polymerases. A key featur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412890042345346738aeab300ae609e8
https://doi.org/10.1158/1535-7163.c.6539653
https://doi.org/10.1158/1535-7163.c.6539653
Autor:
Alexey V. Danilov, Peter Hurlin, Justin Cidado, Lisa Drew, Prabhjot Kaur, Craig Y. Okada, Erin W. Gilbert, Joelle Wolf, Cody J. Paiva, Olga Danilova, Vi Lam, Scott Best, Nur Bruss, Taylor Hashiguchi
Supplemental Methods, Table and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca20e510aa6145a855b01ce36099cce0
https://doi.org/10.1158/1535-7163.22510558
https://doi.org/10.1158/1535-7163.22510558
Autor:
Vi Lam, Nur Bruss, Alexey V. Danilov, Olga V. Danilova, Guang Fan, Tingting Liu, Scott R Best, Adam Kittai
Publikováno v:
Oncotarget
Peripheral T-cell lymphoma (PTCL) is characterized by poor outcomes. We and others have shown that targeting the NEDD8-activating enzyme (NAE) with an investigational inhibitor pevonedistat deregulates cell cycle and mitosis in lymphoma and leukemia.
Autor:
Tingting Liu, Vi Lam, Elana Thieme, Olga Danilova, Nur Bruss, Lapo Alinari, Jeffrey W. Tyner, Stephen E. Kurtz, Zheng Xia, Alexey V Danilov
Publikováno v:
Blood. 140:6016-6017
Autor:
Tingting Liu, Vi Lam, Duanchen Sun, Elana Thieme, Tamilla Nechiporuk, Daniel Bottomly, Olga V Danilova, Nur Bruss, Martina Cusan, Lili Wang, Shannon K McWeeney, Jeffrey W Tyner, Steve Kurtz, Zheng Xia, Alexey Danilov
Publikováno v:
Blood Cancer Discovery. 3:A02-A02
SUMOylation is a post-translational modification that leads to covalent attachment of small ubiquitin-like modifiers (SUMO) proteins to a target protein. SUMOylation is essential for the regulation of genomic integrity, gene expression and intracellu
Autor:
Elana Thieme, Duanchen Sun, Nur Bruss, Geeta Sharma, Tingting Liu, Daniel Coleman, Tamilla Nechiporuk, Daniel Bottomly, Shannon McWeeney, Patrick Pirrotte, Zheng Xia, Alexey Danilov
Publikováno v:
Blood Cancer Discovery. 3:A06-A06
Introduction Oncogenic programs are facilitated by activators of transcriptional machinery, including certain CDKs. CDK9, a component of the positive transcription elongation factor b (pTEFb) complex, has arisen as an attractive target due to its reg
Autor:
Evan F. Lind, Vi Lam, Nathan D. Pennock, Scott R Best, Adam Kittai, Alexey V. Danilov, Nur Bruss, Allison Berger, Susan E. Murray, Tingting Liu, Olga V. Danilova
Publikováno v:
Leukemia
Novel targeted agents used in therapy of lymphoid malignancies, such as inhibitors of B-cell receptor-associated kinases, are recognized to have complex immune-mediated effects. NEDD8-activating enzyme (NAE) has been identified as a tractable target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcae410fe576a9e2b7a646012b4569dc
https://europepmc.org/articles/PMC8288064/
https://europepmc.org/articles/PMC8288064/
Autor:
Olga V. Danilova, Tanya Siddiqi, Scott R Best, Tingting Liu, Nur Bruss, Alexey V. Danilov, Xiaoguang Wang, Vi Lam, Nathan D. Pennock
Publikováno v:
Blood. 138:3719-3719
Introduction: CLL is characterized by deficient immunity which clinically manifests as increased predisposition towards malignancies and infectious complications. T-cells from patients with CLL exhibit a skewed repertoire with predominance of Tregs a