Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nupura Hirve"'
Autor:
Aparna Gudlur, Ana Eliza Zeraik, Nupura Hirve, V. Rajanikanth, Andrey A. Bobkov, Guolin Ma, Sisi Zheng, Youjun Wang, Yubin Zhou, Elizabeth A. Komives, Patrick G. Hogan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological activ
Externí odkaz:
https://doaj.org/article/500001afbcee44e78123ce02e0c9e9ab
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 72-83 (2018)
Summary: STIM1 and STIM2 are endoplasmic reticulum (ER) membrane proteins that sense decreases in ER-luminal free Ca2+ and, through a conformational change in the STIM cytoplasmic domain, control gating of the plasma membrane Ca2+ channel ORAI1. To d
Externí odkaz:
https://doaj.org/article/f963463348c34d2590f33531becfef7b
Autor:
David M Guimond, Nicholas R Cam, Nupura Hirve, Wei Duan, John D Lambris, Michael Croft, Constantine D Tsoukas
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63645 (2013)
The inducible T cell kinase (ITK) regulates type 2 (Th2) cytokines that provide defense against certain parasitic and bacterial infections and are involved in the pathogenesis of lung inflammation such as allergic asthma. Activation of ITK requires t
Externí odkaz:
https://doaj.org/article/edf470c0afbc4eea888e37cb6147f104
Autor:
Nupura Hirve, Roman M Levytskyy, Stephanie Rigaud, David M Guimond, Tomasz Zal, Karsten Sauer, Constantine D Tsoukas
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45158 (2012)
Binding of the membrane phospholipid phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protein tyrosine kinase, Inducible T cell Kinase (ITK), is critical for the recruitment of the kinase to t
Externí odkaz:
https://doaj.org/article/97cbf54ebbe84f86a9ad66d1ea411332
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 72-83 (2018)
Summary: STIM1 and STIM2 are endoplasmic reticulum (ER) membrane proteins that sense decreases in ER-luminal free Ca2+ and, through a conformational change in the STIM cytoplasmic domain, control gating of the plasma membrane Ca2+ channel ORAI1. To d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e529592e6636ff6ba7fca63448ceb75b
http://www.sciencedirect.com/science/article/pii/S2211124717318399
http://www.sciencedirect.com/science/article/pii/S2211124717318399
Publikováno v:
J Physiol
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular calcium balance. Stromal interaction mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fe779e623ac172ccc5afc2b5d52279
https://europepmc.org/articles/PMC6925660/
https://europepmc.org/articles/PMC6925660/
Autor:
Andrey A. Bobkov, Vangipurapu Rajanikanth, Sisi Zheng, Yubin Zhou, Youjun Wang, Nupura Hirve, Patrick G. Hogan, Guolin Ma, Aparna Gudlur, Elizabeth A. Komives, Ana Eliza Zeraik
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2+ levels to maintain cellular Ca2+ balance and to support Ca2+ signalling. The prevailing view has been that STIM1 senses reduced ER Ca2+ through dissociation of bound Ca2+ from a single E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e74c3a68c318f33178b0e8e79689e2
https://doi.org/10.1038/s41467-018-06816-8
https://doi.org/10.1038/s41467-018-06816-8
Autor:
Vangipurapu Rajanikanth, Nupura Hirve, Aparna Gudlur, Andrey A. Bobkov, Elizabeth A. Komives, Patrick G. Hogan, Ana Eliza Zeraik
Publikováno v:
Biophysical Journal. 116:43a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::440a08f0b0f3a889a2683f6120ba47ef
https://doi.org/10.1016/j.bpj.2018.11.276
https://doi.org/10.1016/j.bpj.2018.11.276
Autor:
Yubin Zhou, Aparna Gudlur, Youjun Wang, Andrey A. Bobkov, Elizabeth A. Komives, Rajanikanth Vangipurapu, Sisi Zheng, Ana Eliza Zeraik, Guolin Ma, Patrick G. Hogan, Nupura Hirve
Publikováno v:
Biophysical Journal. 114:285a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ff4f9d72e0d48b9f9edd19d0d0c6d5a
https://doi.org/10.1016/j.bpj.2017.11.1635
https://doi.org/10.1016/j.bpj.2017.11.1635
Autor:
Aparna Gudlur, Sahasransu Mahapatra, Ariel Quintana, Nupura Hirve, Patrick G. Hogan, Yubin Zhou
Publikováno v:
Nature communications
The ER-resident regulatory protein STIM1 triggers store-operated Ca(2+) entry by direct interaction with the plasma membrane Ca(2+) channel ORAI1. The mechanism of channel gating remains undefined. Here we establish that STIM1 gates the purified reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74f09132c5281dfbba0acc4ae6d1816
https://doi.org/10.1038/ncomms6164
https://doi.org/10.1038/ncomms6164