Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Nupam P. Mahajan"'
Autor:
Surbhi Chouhan, Dhivya Sridaran, Cody Weimholt, Jingqin Luo, Tiandao Li, Myles C. Hodgson, Luana N. Santos, Samantha Le Sommer, Bin Fang, John M. Koomen, Markus Seeliger, Cheng-Kui Qu, Armelle Yart, Maria I. Kontaridis, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded by PTPN11), promotes developmental disorders and several malignancies by varying phosphatase activity. We uncovered that SHP2 is a distinct class of
Externí odkaz:
https://doaj.org/article/8786074726574cf993ac21c17b758fad
Autor:
Duy T. Nguyen, Urvashi Mahajan, Duminduni Hewa Angappulige, Aashna Doshi, Nupam P. Mahajan, Kiran Mahajan
Publikováno v:
Cancers, Vol 16, Iss 9, p 1622 (2024)
Advanced localized prostate cancers (PC) recur despite chemotherapy, radiotherapy and/or androgen deprivation therapy. We recently reported HOXB13 lysine (K)13 acetylation as a gain-of-function modification that regulates interaction with the SWI/SNF
Externí odkaz:
https://doaj.org/article/4226f8d8e4254affad27d5e779eab6b0
Autor:
Thanh Nguyen, Dhivya Sridaran, Surbhi Chouhan, Cody Weimholt, Audrey Wilson, Jingqin Luo, Tiandao Li, John Koomen, Bin Fang, Nagireddy Putluri, Arun Sreekumar, Felix Y. Feng, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The testicular androgen biosynthesis is well understood, however, how cancer cells gauge dwindling androgen to dexterously initiate its de novo synthesis remained elusive. We uncover dual-phosphorylated form of sterol regulatory element-bind
Externí odkaz:
https://doaj.org/article/6796f1304f8b4aaf971cec547d08d83d
Autor:
Nimrod S. Barashi, Tiandao Li, Duminduni H. Angappulige, Bo Zhang, Harry O’Gorman, Charles U. Nottingham, Anup S. Shetty, Joseph E. Ippolito, Gerald L. Andriole, Nupam P. Mahajan, Eric H. Kim, Kiran Mahajan
Publikováno v:
Cancers, Vol 16, Iss 1, p 213 (2024)
Our objective was to identify variations in gene expression that could help elucidate the pathways for the development of prostate cancer (PCa) in men with Benign Prostatic Hyperplasia (BPH). We included 98 men with BPH, a positive prostate MRI (Pros
Externí odkaz:
https://doaj.org/article/4b211a42e523480ab81184d85d33c71a
Autor:
Dhivya Sridaran, Surbhi Chouhan, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Shambhavi Bhagwat, Melissa Reimers, Eric H. Kim, Manish K. Thakur, Muhammad A. Saeed, Russell K. Pachynski, Markus A. Seeliger, W. Todd Miller, Felix Y. Feng, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Immune checkpoint blockade is showing promise in cancer immune therapy, but many solid tumours are resistant. Authors here identify a pathway in T cells that leads to increased activity of C-terminal Src kinase, a negative regulator of T cell activit
Externí odkaz:
https://doaj.org/article/7caeec47da1c4212a9d6e0933f20b457
Autor:
Thanh Nguyen, Dhivya Sridaran, Surbhi Chouhan, Cody Weimholt, Audrey Wilson, Jingqin Luo, Tiandao Li, John Koomen, Bin Fang, Nagireddy Putluri, Arun Sreekumar, Felix Y. Feng, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/bd78901281fb43119a54924b66bf7d3f
Autor:
Duy T. Nguyen, Wei Yang, Arun Renganathan, Cody Weimholt, Duminduni H. Angappulige, Thanh Nguyen, Robert W. Sprung, Gerald L. Andriole, Eric H. Kim, Nupam P. Mahajan, Kiran Mahajan
Publikováno v:
Clin Cancer Res
Purpose: Androgen receptor (AR) antagonism is exacerbated by HOXB13 in castration-resistant prostate cancers (CRPC). However, it is unclear when and how HOXB13 primes CRPCs for AR antagonism. By mass-spectrometry analysis of CRPC extract, we uncovere
Autor:
Kiran Mahajan, Nupam P. Mahajan, Eric H. Kim, Gerald L. Andriole, Robert W. Sprung, Thanh Nguyen, Duminduni H. Angappulige, Cody Weimholt, Arun Renganathan, Wei Yang, Duy T. Nguyen
Supplementary Table from Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc956e3ca1e86c315b620390815b4b8
https://doi.org/10.1158/1078-0432.22488789
https://doi.org/10.1158/1078-0432.22488789
Autor:
Kiran Mahajan, Nupam P. Mahajan, Eric H. Kim, Gerald L. Andriole, Robert W. Sprung, Thanh Nguyen, Duminduni H. Angappulige, Cody Weimholt, Arun Renganathan, Wei Yang, Duy T. Nguyen
Purpose:Androgen receptor (AR) antagonism is exacerbated by HOXB13 in castration-resistant prostate cancers (CRPC). However, it is unclear when and how HOXB13 primes CRPCs for AR antagonism. By mass-spectrometry analysis of CRPC extract, we uncovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743076cce3cd4ab850bfe20212ed9c13
https://doi.org/10.1158/1078-0432.c.6532809
https://doi.org/10.1158/1078-0432.c.6532809
Autor:
Kiran Mahajan, Nupam P. Mahajan, Eric H. Kim, Gerald L. Andriole, Robert W. Sprung, Thanh Nguyen, Duminduni H. Angappulige, Cody Weimholt, Arun Renganathan, Wei Yang, Duy T. Nguyen
Supplementary Data from Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622607fb2a550ebfb80518c058b948b5
https://doi.org/10.1158/1078-0432.22488864
https://doi.org/10.1158/1078-0432.22488864