Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Nupam P, Mahajan"'
Autor:
Surbhi Chouhan, Dhivya Sridaran, Cody Weimholt, Jingqin Luo, Tiandao Li, Myles C. Hodgson, Luana N. Santos, Samantha Le Sommer, Bin Fang, John M. Koomen, Markus Seeliger, Cheng-Kui Qu, Armelle Yart, Maria I. Kontaridis, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded by PTPN11), promotes developmental disorders and several malignancies by varying phosphatase activity. We uncovered that SHP2 is a distinct class of
Externí odkaz:
https://doaj.org/article/8786074726574cf993ac21c17b758fad
Autor:
Thanh Nguyen, Dhivya Sridaran, Surbhi Chouhan, Cody Weimholt, Audrey Wilson, Jingqin Luo, Tiandao Li, John Koomen, Bin Fang, Nagireddy Putluri, Arun Sreekumar, Felix Y. Feng, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The testicular androgen biosynthesis is well understood, however, how cancer cells gauge dwindling androgen to dexterously initiate its de novo synthesis remained elusive. We uncover dual-phosphorylated form of sterol regulatory element-bind
Externí odkaz:
https://doaj.org/article/6796f1304f8b4aaf971cec547d08d83d
Autor:
Dhivya Sridaran, Surbhi Chouhan, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Shambhavi Bhagwat, Melissa Reimers, Eric H. Kim, Manish K. Thakur, Muhammad A. Saeed, Russell K. Pachynski, Markus A. Seeliger, W. Todd Miller, Felix Y. Feng, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Immune checkpoint blockade is showing promise in cancer immune therapy, but many solid tumours are resistant. Authors here identify a pathway in T cells that leads to increased activity of C-terminal Src kinase, a negative regulator of T cell activit
Externí odkaz:
https://doaj.org/article/7caeec47da1c4212a9d6e0933f20b457
Autor:
Thanh Nguyen, Dhivya Sridaran, Surbhi Chouhan, Cody Weimholt, Audrey Wilson, Jingqin Luo, Tiandao Li, John Koomen, Bin Fang, Nagireddy Putluri, Arun Sreekumar, Felix Y. Feng, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/bd78901281fb43119a54924b66bf7d3f
Autor:
Duy T. Nguyen, Wei Yang, Arun Renganathan, Cody Weimholt, Duminduni H. Angappulige, Thanh Nguyen, Robert W. Sprung, Gerald L. Andriole, Eric H. Kim, Nupam P. Mahajan, Kiran Mahajan
Publikováno v:
Clin Cancer Res
Purpose: Androgen receptor (AR) antagonism is exacerbated by HOXB13 in castration-resistant prostate cancers (CRPC). However, it is unclear when and how HOXB13 primes CRPCs for AR antagonism. By mass-spectrometry analysis of CRPC extract, we uncovere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63004ae596807ca9cbc8293255fed56
https://doi.org/10.1158/1078-0432.ccr-21-3603
https://doi.org/10.1158/1078-0432.ccr-21-3603
Autor:
Kiran Mahajan, Nupam P. Mahajan, Eric H. Kim, Gerald L. Andriole, Robert W. Sprung, Thanh Nguyen, Duminduni H. Angappulige, Cody Weimholt, Arun Renganathan, Wei Yang, Duy T. Nguyen
Supplementary Table from Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc956e3ca1e86c315b620390815b4b8
https://doi.org/10.1158/1078-0432.22488789
https://doi.org/10.1158/1078-0432.22488789
Autor:
Kiran Mahajan, Nupam P. Mahajan, Eric H. Kim, Gerald L. Andriole, Robert W. Sprung, Thanh Nguyen, Duminduni H. Angappulige, Cody Weimholt, Arun Renganathan, Wei Yang, Duy T. Nguyen
Purpose:Androgen receptor (AR) antagonism is exacerbated by HOXB13 in castration-resistant prostate cancers (CRPC). However, it is unclear when and how HOXB13 primes CRPCs for AR antagonism. By mass-spectrometry analysis of CRPC extract, we uncovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743076cce3cd4ab850bfe20212ed9c13
https://doi.org/10.1158/1078-0432.c.6532809
https://doi.org/10.1158/1078-0432.c.6532809
Autor:
Kiran Mahajan, Nupam P. Mahajan, Eric H. Kim, Gerald L. Andriole, Robert W. Sprung, Thanh Nguyen, Duminduni H. Angappulige, Cody Weimholt, Arun Renganathan, Wei Yang, Duy T. Nguyen
Supplementary Data from Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622607fb2a550ebfb80518c058b948b5
https://doi.org/10.1158/1078-0432.22488864
https://doi.org/10.1158/1078-0432.22488864
Autor:
Kiran Mahajan, Nupam P. Mahajan, Eric H. Kim, Gerald L. Andriole, Robert W. Sprung, Thanh Nguyen, Duminduni H. Angappulige, Cody Weimholt, Arun Renganathan, Wei Yang, Duy T. Nguyen
Supplementary Figure from Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4510aff9b0cb729271688d374654c7
https://doi.org/10.1158/1078-0432.22488828
https://doi.org/10.1158/1078-0432.22488828
Autor:
Nupam P. Mahajan, Felix Y. Feng, Christopher A. Maher, Ha X. Dang, Jingqin Luo, Eric H. Kim, Kiran Mahajan, Arun Renganathan, Mithila Sawant, Ruchi Ghildiyal
Supplementary Figures 1-10 and Tables 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027624eefe0bbfdc5d1b5528b3b9db23
https://doi.org/10.1158/0008-5472.22429800
https://doi.org/10.1158/0008-5472.22429800