Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Nunzio Iraci"'
Autor:
Emanuele Martorana, Gabriele Raciti, Raffaella Giuffrida, Elena Bruno, Vincenzo Ficarra, Giuseppe Mario Ludovico, Nazareno Roberto Suardi, Nunzio Iraci, Loredana Leggio, Benedetta Bussolati, Cristina Grange, Aurelio Lorico, Rosario Leonardi, Stefano Forte
Publikováno v:
Cells, Vol 13, Iss 15, p 1286 (2024)
Background: Prostate cancer is the second most common cancer in males worldwide, and its incidence is rising. Early detection is crucial for improving the outcomes, but the current screening methods have limitations. While prostate-specific antigen (
Externí odkaz:
https://doaj.org/article/2745159f79614f2baa9b1953abc5afc8
Autor:
Claudio Stagno, Francesca Mancuso, Tania Ciaglia, Carmine Ostacolo, Anna Piperno, Nunzio Iraci, Nicola Micale
Publikováno v:
Molecules, Vol 29, Iss 13, p 3234 (2024)
The growing interest in Kv7.2/7.3 agonists originates from the involvement of these channels in several brain hyperexcitability disorders. In particular, Kv7.2/7.3 mutants have been clearly associated with epileptic encephalopathies (DEEs) as well as
Externí odkaz:
https://doaj.org/article/81562414ff3f4ae3b8d16f1636c21cc4
Autor:
Francesca Di Matteo, Francesca Mancuso, Rita Turcio, Tania Ciaglia, Claudio Stagno, Carla Di Chio, Pietro Campiglia, Alessia Bertamino, Salvatore Vincenzo Giofrè, Carmine Ostacolo, Nunzio Iraci
Publikováno v:
Molecules, Vol 29, Iss 12, p 2940 (2024)
Potassium channels have recently emerged as suitable target for the treatment of epileptic diseases. Among potassium channels, KCNT1 channels are the most widely characterized as responsible for several epileptic and developmental encephalopathies. N
Externí odkaz:
https://doaj.org/article/a8ece3bfd3c04e12bd279b9e1518a461
Autor:
Loredana Leggio, Greta Paternò, Silvia Vivarelli, Aurelio Bonasera, Bruno Pignataro, Nunzio Iraci, Giuseppe Arrabito
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108105- (2023)
Summary: Extracellular vesicles (EVs) represent pivotal mediators in cell-to-cell communication. They are lipid-membranous carriers of several biomolecules, which can be produced by almost all cells. In the current Era of precision medicine, EVs gain
Externí odkaz:
https://doaj.org/article/db207794b2724f29b470298fcd63f320
The Anti-Cancer Activity of the Naturally Occurring Dipeptide Carnosine: Potential for Breast Cancer
Autor:
Salvatore Maugeri, Jay Sibbitts, Anna Privitera, Vincenzo Cardaci, Lucia Di Pietro, Loredana Leggio, Nunzio Iraci, Susan M. Lunte, Giuseppe Caruso
Publikováno v:
Cells, Vol 12, Iss 22, p 2592 (2023)
Carnosine is an endogenous dipeptide composed of β-alanine and L-histidine, possessing a multimodal pharmacodynamic profile that includes anti-inflammatory and anti-oxidant activities. Carnosine has also shown its ability to modulate cell proliferat
Externí odkaz:
https://doaj.org/article/de1dc1e053f94f37b23769dd963e7520
Autor:
Giulia Marsili, Chiara Acchioni, Anna Lisa Remoli, Donatella Amatore, Rossella Sgarbanti, Marta De Angelis, Roberto Orsatti, Marta Acchioni, Andrea Astolfi, Nunzio Iraci, Simona Puzelli, Marzia Facchini, Edvige Perrotti, Violetta Cecchetti, Stefano Sabatini, Fabiana Superti, Mariangela Agamennone, Maria Letizia Barreca, John Hiscott, Lucia Nencioni, Marco Sgarbanti
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10495 (2023)
There is an urgent need to identify efficient antiviral compounds to combat existing and emerging RNA virus infections, particularly those related to seasonal and pandemic influenza outbreaks. While inhibitors of the influenza viral integral membrane
Externí odkaz:
https://doaj.org/article/d243f30a22d54fe2883c6705e50abb4f
Autor:
Antonella Smeriglio, Nunzio Iraci, Marcella Denaro, Giuseppina Mandalari, Salvatore Vincenzo Giofrè, Domenico Trombetta
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 972 (2023)
Recently, we demonstrated that a Citrus flavanone mix (FM) shows antioxidant and anti-inflammatory activity, even after gastro-duodenal digestion (DFM). The aim of this study was to investigate the possible involvement of the cyclooxygenases (COXs) i
Externí odkaz:
https://doaj.org/article/448cae54dd884f8d8c922c1d53b6fd17
Autor:
Federica De Gaetano, Angela Scala, Consuelo Celesti, Kim Lambertsen Larsen, Fabio Genovese, Corrado Bongiorno, Loredana Leggio, Nunzio Iraci, Antonino Mazzaglia, Cinzia Anna Ventura
Publikováno v:
Molecules, Vol 28, Iss 7, p 3023 (2023)
Idebenone (IDE), a synthetic short-chain analogue of coenzyme Q10, is a potent antioxidant able to prevent lipid peroxidation and stimulate nerve growth factor. Due to these properties, IDE could potentially be active towards cerebral disorders, but
Externí odkaz:
https://doaj.org/article/ce6288f35af24867af5b819332a9a32a
Autor:
Maria Letizia Di Pietro, Claudio Stagno, Thomas Efferth, Ejlal A. Omer, Valeria D’Angelo, Maria Paola Germanò, Anna Cacciola, Federica De Gaetano, Nunzio Iraci, Nicola Micale
Publikováno v:
Molecules, Vol 27, Iss 24, p 9000 (2022)
Transition metal complexes have continued to constitute an appealing class of medicinal compounds since the exceptional discovery of cisplatin in the late 1960s. Pt(II)-based complexes are endowed with a broad range of biological properties, which ar
Externí odkaz:
https://doaj.org/article/88e26b6182bb41c2aae610376ea752a1
Autor:
Federica De Gaetano, Maria Chiara Cristiano, Donatella Paolino, Consuelo Celesti, Daniela Iannazzo, Venerando Pistarà, Nunzio Iraci, Cinzia Anna Ventura
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1716 (2022)
Bicalutamide (BCL) is a nonsteroidal antiandrogen drug that represents an alternative to castration in the treatment of prostate cancer, due to its relatively long half-life and tolerable side effects. However, it possesses a very low water solubilit
Externí odkaz:
https://doaj.org/article/82b03bbf308847a8aa2e20ef95938b8c