Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Nunzio Del Gaudio"'
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-4 (2024)
Abstract Gene expression is an intricate biological process that bridges gap between the genotype and the phenotype. Canonical and hereditable epigenetic mechanisms, such as histone and DNA modifications, regulate the release of genetic information e
Externí odkaz:
https://doaj.org/article/a3c1e332af5f46608acfc61505896699
Autor:
Chiara Papulino, Ugo Chianese, Ahmad Ali, Gregorio Favale, Concetta Tuccillo, Fortunato Ciardiello, Annabella Di Mauro, Chiara Mignogna, Gerardo Ferrara, Alfredo Budillon, Wouter Leonard Megchelenbrink, Nunzio Del Gaudio, Mariarosaria Conte, Fabrizio Merciai, Pietro Campiglia, Lucia Altucci, Vincenzo Carafa, Eduardo Sommella, Rosaria Benedetti
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Breast cancer manifests as a heterogeneous pathology marked by complex metabolic reprogramming essential to satisfy its energy demands. Oncogenic signals boost the metabolism, modifying fatty acid synthesis and glucose use from th
Externí odkaz:
https://doaj.org/article/e1c9da9a03da4c08b5e34b1d243a2230
Autor:
Liliana Montella, Luigi Di Marino, Maria Adele Marino, Vittorio Riccio, Nunzio Del Gaudio, Lucia Altucci, Massimiliano Berretta, Gaetano Facchini
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundHormone receptor-positive tumors are unlikely to exhibit a complete pathological tumor response. The association of CDK 4/6 inhibitor plus hormone therapy has changed this perspective.Case presentationIn this study, we retrospectively revie
Externí odkaz:
https://doaj.org/article/7505e308e5744e11b929d6a0c6747758
Autor:
Roberta Pacifico, Nunzio Del Gaudio, Guglielmo Bove, Lucia Altucci, Lydia Siragusa, Gabriele Cruciani, Menotti Ruvo, Rosa Bellavita, Paolo Grieco, Mauro F. A. Adamo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1987-1994 (2022)
We have recently developed a new synthetic methodology that provided both N-aryl-5-hydroxytriazoles and N-pyridine-4-alkyl triazoles. A selection of these products was carried through virtual screening towards targets that are contemporary and valida
Externí odkaz:
https://doaj.org/article/f9c5fcf1b41543b299f0dd8f3efb65c3
Autor:
Yanan Zhai, Prashant Singh, Anna Dolnik, Peter Brazda, Nader Atlasy, Nunzio del Gaudio, Konstanze Döhner, Hartmut Döhner, Saverio Minucci, Joost Martens, Lucia Altucci, Wout Megchelenbrink, Lars Bullinger, Hendrik G. Stunnenberg
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background Acute myeloid leukemia (AML) is a heterogeneous and aggressive blood cancer that results from diverse genetic aberrations in the hematopoietic stem or progenitor cells (HSPCs) leading to the expansion of blasts in the hematopoieti
Externí odkaz:
https://doaj.org/article/cdc5c6225a8845a29d882f5c207da3a3
Autor:
Nunzio Del Gaudio, Antonella Di Costanzo, Ning Qing Liu, Lidio Conte, Carmela Dell’Aversana, Guglielmo Bove, Rosaria Benedetti, Liliana Montella, Fortunato Ciardiello, Vincenzo Carafa, Concetta Ambrosino, Valeria Tucci, Mariarosaria Conte, Joost H. A. Martens, Hendrik G. Stunnenberg, Angela Nebbioso, Lucia Altucci
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovered chromatin readers i
Externí odkaz:
https://doaj.org/article/07529a4a602742c3a53ad8261632a83c
Autor:
Ugo Chianese, Chiara Papulino, Eugenia Passaro, Tom MJ. Evers, Mehrad Babaei, Antonella Toraldo, Tommaso De Marchi, Emma Niméus, Vincenzo Carafa, Maria Maddalena Nicoletti, Nunzio Del Gaudio, Nunzia Iaccarino, Antonio Randazzo, Dante Rotili, Antonello Mai, Salvatore Cappabianca, Alireza Mashaghi, Fortunato Ciardiello, Lucia Altucci, Rosaria Benedetti
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101561- (2022)
Objective: Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, fac
Externí odkaz:
https://doaj.org/article/df67d4dd16fd48ec98c9149449174dcf
Autor:
Liliana Montella, Nunzio Del Gaudio, Guglielmo Bove, Mariella Cuomo, Michela Buonaiuto, Davide Costabile, Roberta Visconti, Gaetano Facchini, Lucia Altucci, Lorenzo Chiariotti, Rosa Della Monica
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastomas are the most frequent and malignant brain tumor hallmarked by an invariably poor prognosis. They have been classically differentiated into primary isocitrate dehydrogenase 1 or 2 (IDH1 -2) wild-type (wt) glioblastoma (GBM) and secondary
Externí odkaz:
https://doaj.org/article/70f43cceeed8489eac57e87cf301a107
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Breast cancer (BC) is the second leading cause of cancer death in women, although recent scientific and technological achievements have led to significant improvements in progression-free disease and overall survival of patients. Genetic mutations an
Externí odkaz:
https://doaj.org/article/b97fca655c0f4f52a6ba5583fbd1b552
