Real-world characteristics of 'super-responders' to mepolizumab and benralizumab in severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis

Autor: Andrea Portacci, Raffaele Campisi, Enrico Buonamico, Santi Nolasco, Corrado Pelaia, Nunzio Crimi, Alida Benfante, Massimo Triggiani, Giuseppe Spadaro, Maria Filomena Caiaffa, Giulia Scioscia, Aikaterini Detoraki, Giuseppe Valenti, Francesco Papia, Alessandra Tomasello, Nicola Scichilone, Girolamo Pelaia, Claudia Crimi, Giovanna Elisiana Carpagnano

Publikováno v: ERJ Open Research, Vol 9, Iss 5 (2023)

Background The current definition of severe eosinophilic asthma (SEA) super-responders to biologic treatment does not include patients with other eosinophil-based comorbidities. Although eosinophilic granulomatosis with polyangiitis (EGPA) is frequen

Externí odkaz: https://doaj.org/article/b1a1bdca6fce4144a5bdd669637b5ce2

Real-life effects of dupilumab in patients with severe type 2 asthma, according to atopic trait and presence of chronic rhinosinusitis with nasal polyps

Autor: Corrado Pelaia, Alida Benfante, Maria Teresa Busceti, Maria Filomena Caiaffa, Raffaele Campisi, Giovanna Elisiana Carpagnano, Nunzio Crimi, Maria D’Amato, Maria Pia Foschino Barbaro, Angelantonio Maglio, Elena Minenna, Santi Nolasco, Giuseppe Paglino, Francesco Papia, Girolamo Pelaia, Andrea Portacci, Luisa Ricciardi, Nicola Scichilone, Giulia Scioscia, Massimo Triggiani, Giuseppe Valenti, Alessandro Vatrella, Claudia Crimi

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundThe efficacy of dupilumab as biological treatment of severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) depends on its ability to inhibit the pathophysiologic mechanisms involved in type 2 inflammation.ObjectiveTo assess in

Externí odkaz: https://doaj.org/article/6af27269a4a84e099db8d6152853d722

Impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system

Autor: Maria Stella Valle, Antonino Casabona, Eugenia Di Fazio, Claudia Crimi, Cristina Russo, Lucia Malaguarnera, Nunzio Crimi, Matteo Cioni

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Chronic obstructive pulmonary disease (COPD) produces skeletal muscle atrophy and weakness, leading to impairments of exercise performance. The mechanical work needed for movement execution is also provided by the passive tension developed b

Externí odkaz: https://doaj.org/article/e069f6202571426090b02b2dcd35e36c

Defining type 2 asthma and patients eligible for dupilumab in Italy: a biomarker-based analysis

Autor: Giorgio Walter Canonica, Francesco Blasi, Nunzio Crimi, Pierluigi Paggiaro, Alberto Papi, Francesca Fanelli, Annalisa Stassaldi, Gianluca Furneri

Publikováno v: Clinical and Molecular Allergy, Vol 19, Iss 1, Pp 1-11 (2021)

Abstract Background Asthma is a chronic disease characterized by airway hyperresponsiveness, inflammation and mucus production. In Type 2 asthma, two phenotypic components are often co-expressed (eosinophilic and allergic). Elevated biomarker levels,

Externí odkaz: https://doaj.org/article/b51099291e614fb0b0787ff7a6fcbed3

Severe asthma: One disease and multiple definitions

Autor: Diego Bagnasco, MD, PhD, Pierluigi Paggiaro, MD, Manuela Latorre, MD, Chiara Folli, BS, Elisa Testino, MD, Arianna Bassi, MD, Manlio Milanese, MD, Enrico Heffler, MD, Andrea Manfredi, Anna Maria Riccio, BS, Laura De Ferrari, BS, Francesco Blasi, Rikki Frank Canevari, MD, Giorgio Walter Canonica, MD, Giovanni Passalacqua, MD, Gabriella Guarnieri, Vincenzo Patella, Foschino Barbaro Maria Pia, Giovanna Elisiana Carpagnano, Anna del Colle, Giulia Scioscia, Pelaia Gerolamo, Francesca Puggioni, Francesca Racca, Elisabetta Favero, Sandra Iannacone, Eleonora Savi, Marcello Montagni, Gianna Camiciottoli, Chiara Allegrini, Carlo Lombardi, Giuseppe Spadaro, Caterina Detoraki, Francesco Menzella, Carla Galeone, Patrizia Ruggiero, Monna Rita Yacoub, Alvise Berti, Nicola Scichilone, Carmen Durante, Maria Teresa Costantino, Chiara Roncallo, Mariachiara Braschi, Alice D’Adda, Erminia Ridolo, Massimo Triggiani, Roberta Parente, D’Amato Maria, Maria Vittoria Verrillo, Giovanni Rolla, Luisa Brussino, Agata Valentina Frazzetto, Zappa Maria Cristina, Marianna Lilli, Nunzio Crimi, Marco Bonavia, Angelo Guido Corsico, Amelia Grosso, Stefano Del Giacco, Margherita Deidda, Luisa Ricciardi, Stefania Isola, Francesca Cicero, Giuliana Amato, Federica Vita, Antonio Spanevello, Patrizia Pignatti, Francesca Cherubino, Dina Visca, Fabio Luigi Massimo Ricciardolo, Vitina Maria Anna Carriero, Francesca Bertolini, Pierachille Santus, Roberta Barlassina, Andrea Airoldi, Giuseppe Guida, Nucera Eleonora, Arianna Aruanno, Angela Rizzi, Cristiano Caruso, Stefania Colantuono, Gianenrico Senna, Marco Caminati, Alessandra Arcolaci, Andrea Vianello, Fulvia Chieco Bianchi, Maria Rita Marchi, Stefano Centanni, Simone Luraschi, Silvia Ruggeri, Rocco Rinaldo, Elena Parazzini, Cecilia Calabrese, Martina Flora, Lorenzo Cosmi, Linda Di Pietro, Enrico Maggi, Laura Pini, Luigi Macchia, Danilo Di Bona, Luca Richeldi, Carola Condoluci, Leonello Fuso, Matteo Bonini, Alessandro Farsi, Giulia Carli, Paolo Montuschi, Giuseppe Santini, Maria Elisabetta Conte, Elisa Turchet, Carlo Barbetta, Francesco Mazza, Simona D’Alo, Stefano Pucci, Maria Filomena Caiaffa, Elena Minenna, Luciana D'Elia, Carlo Pasculli, Vittorio Viviano, Paolo Tarsia, Joyce Rolo, Mariacarmela Di Proietto, Salvatore Lo Cicero

Publikováno v: World Allergy Organization Journal, Vol 14, Iss 11, Pp 100606- (2021)

Introduction: There is, so far, no universal definition of severe asthma. This definition usually relies on: number of exacerbations, inhaled therapy, need for oral corticosteroids, and respiratory function. The use of such parameters varies in the d

Externí odkaz: https://doaj.org/article/8bd465ece0db4a60b1326728338e4570