Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nunzio, Sciammetta"'
Autor:
Hanguang Yu, Andrew Herschfelt, Shunyao Wu, Sharanya Srinivas, Yang Li, Nunzio Sciammetta, Leslie Smith, Klaus Rueger, Hyunseok Lee, Chaitali Chakrabarti, Daniel W. Bliss
Publikováno v:
Sensors, Vol 23, Iss 3, p 1343 (2023)
Spectral congestion and modern consumer applications motivate radio technologies that efficiently cooperate with nearby users and provide several services simultaneously. We designed and implemented a joint positioning-communications system that simu
Externí odkaz:
https://doaj.org/article/844fdd33af7146a2baa7ac73f82f1032
Autor:
Benjamin Umiker, Hyun-Hee Lee, Julia Cope, Nadim J. Ajami, Jean-Philippe Laine, Christine Fregeau, Heidi Ferguson, Stephen E Alves, Nunzio Sciammetta, Melanie Kleinschek, Michael Salmon
Publikováno v:
Innate Immunity, Vol 25 (2019)
Crohn’s disease (CD) is a chronic disorder of the gastrointestinal tract characterized by inflammation and intestinal epithelial injury. Loss of function mutations in the intracellular bacterial sensor NOD2 are major risk factors for the developmen
Externí odkaz:
https://doaj.org/article/cc0221bbdaa040889d91e9a575c129f6
Autor:
Markus Klugel, Aygun Baltaci, Fabien Geyer, Nunzio Sciammetta, Svetoslav Duhovnikov, Dominic Schupke
Publikováno v:
IEEE Communications Magazine. 60:32-37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ad13aa499f00864185250956c73712
https://doi.org/10.1109/mcom.001.2100901
https://doi.org/10.1109/mcom.001.2100901
Autor:
Chunhui Huang, Christian Fischer, Michelle R. Machacek, Stephane Bogen, Tesfaye Biftu, Xianhai Huang, Michael H. Reutershan, Ryan Otte, Qingmei Hong, Zhicai Wu, Yang Yu, Min Park, Lei Chen, Purakkattle Biju, Ian Knemeyer, Ping Lu, Christopher J. Kochansky, Michael Brendan Hicks, Yong Liu, Roy Helmy, Xavier Fradera, Anthony Donofrio, Josh Close, Matthew L. Maddess, Catherine White, David L. Sloman, Nunzio Sciammetta, Jun Lu, Craig Gibeau, Vladimir Simov, Hongjun Zhang, Peter Fuller, David Witter
Publikováno v:
ACS Med Chem Lett
[Image: see text] Mutant isocitrate dehydrogenase 1 (IDH1) has been identified as an attractive oncology target for which >70% of grade II and III gliomas and ∼10% of acute myeloid leukemia (AML) harbor somatic IDH1 mutations. These mutations confe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ecfd534a4182e5c705a82b16c3ffcc
https://europepmc.org/articles/PMC9014435/
https://europepmc.org/articles/PMC9014435/
Autor:
Derun Li, David L. Sloman, Abdelghani Achab, Hua Zhou, Meredeth A. McGowan, Catherine White, Craig Gibeau, Hongjun Zhang, Qinglin Pu, Indu Bharathan, Brett Hopkins, Kun Liu, Heidi Ferguson, Xavier Fradera, Charles A. Lesburg, Theodore A. Martinot, Ji Qi, Zhiguo J. Song, Jingjun Yin, Huangguang Zhang, Licheng Song, Baoqiang Wan, Suzanne DAddio, Nicolas Solban, J. Richard Miller, Beata Zamlynny, Alan Bass, Elizabeth Freeland, Bridget Ykoruk, Catherine Hilliard, Jude Ferraro, Jin Zhai, Ian Knemeyer, Karin M. Otte, Stella Vincent, Nunzio Sciammetta, Alexander Pasternak, David Jonathan Bennett, Yongxin Han
Publikováno v:
Journal of medicinal chemistry. 65(8)
3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane functionalities. We report the discovery of a novel class of oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors suitable for Q3W (once every 3 weeks) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65de888aa90fb7088ca022d5b5ddf12
https://pubmed.ncbi.nlm.nih.gov/35239336
https://pubmed.ncbi.nlm.nih.gov/35239336
Autor:
Nicolas Solban, Alexander Pasternak, Qinglin Pu, Amy C. Doty, David Jonathan Bennett, Charles A. Lesburg, Wensheng Yu, Prasanthi Geda, Nunzio Sciammetta, J. Richard Miller, Hua Zhou, Xuelei Song, Yongxin Han, Lars Neumann, David L. Sloman, Mangeng Cheng, Heidi Ferguson, Karin M. Otte, Liangqin Guo, Hongjun Zhang, Alfred Lammens, Xavier Fradera, Meredeth A. McGowan
Publikováno v:
ACS Med Chem Lett
[Image: see text] Indoleamine-2,3-dioxygenase 1 (IDO1) inhibition and its combination with immune checkpoint inhibitors like pembrolizumab have drawn considerable attention from both academia and the pharmaceutical industry. Here, we describe the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc457a333eeebf89280777405619540
https://doi.org/10.1021/acsmedchemlett.0c00195
https://doi.org/10.1021/acsmedchemlett.0c00195
Autor:
Matthew H. Daniels, Sunil Nagpal, Blair T. Lapointe, Jos Cals, Mario van der Stelt, Vladimir Simov, Willem Jan Karstens, Sujal V. Deshmukh, Kenneth Jay Barr, J. Richard Miller, Hans van Eenenaam, Craig C. Correll, John Maclean, Laxminarayan G Hegde, Lily Y. Moy, B. Wesley Trotter, Rachel L. Palte, Janice D Woodhouse, Nunzio Sciammetta, Gopal Parthasarathy, Heidi Ferguson, Rita Azevedo, Hongjun Zhang, Arthur Oubrie, Neville J. Anthony
Publikováno v:
ACS Medicinal Chemistry Letters. 11:114-119
The clinical success of anti-IL-17 monoclonal antibodies (i.e., Cosentyx and Taltz) has validated Th17 pathway modulation for the treatment of autoimmune diseases. The nuclear hormone receptor RORγt is a master regulator of Th17 cells and affects th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927a9a20903f38d39770d2e5897d3e47
https://doi.org/10.1021/acsmedchemlett.9b00431
https://doi.org/10.1021/acsmedchemlett.9b00431
Autor:
Theodore A. Martinot, Xavier Fradera, Meredeth A. McGowan, Wensheng Yu, Heidi Ferguson, Purakattle J Biju, H. Zhou, Nicolas Solban, Qinglin Pu, Yongxin Han, Xiao Wang, Kun Liu, Ravi Kurukulasuriya, Yu-hong Lam, Abdelghani Achab, Karin M. Otte, Michael J. Ardolino, Amy C. Doty, Charles A. Lesburg, J. Richard Miller, Yongqi Deng, Mangeng Cheng, Hongjun Zhang, Ian Knemeyer, Nunzio Sciammetta, David Jonathan Bennett
Publikováno v:
ACS Med Chem Lett
[Image: see text] Checkpoint inhibitors have demonstrated unprecedented efficacy and are evolving to become standard of care for certain types of cancers. However, low overall response rates often hamper the broad utility and potential of these break
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30fa3b8f261ace5c7d56e064b7047fa
https://doi.org/10.1021/acsmedchemlett.9b00344
https://doi.org/10.1021/acsmedchemlett.9b00344
Autor:
Sookhee Ha, Nunzio Sciammetta, Graham Smith, Spencer McMinn, Berengere Sauvagnat, Brett A. Hopkins, Hyelee Lee, Lisa Nogle
Publikováno v:
ACS Med Chem Lett
[Image: see text] As more macrocycle structures are utilized to drug intracellular targets, new platforms are needed to facilitate the discovery of cell permeable compounds in this unique chemical space. Herein, a method is disclosed that allows for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5267830998450d6258eb800b78fb6d1e
https://doi.org/10.1021/acsmedchemlett.9b00036
https://doi.org/10.1021/acsmedchemlett.9b00036
Autor:
Stephen E. Alves, Christine Fregeau, Nadim J. Ajami, Julia L. Cope, Michael Salmon, Jean-Philippe Laine, Nunzio Sciammetta, Hyun-Hee Lee, Heidi Ferguson, Melanie A. Kleinschek, Benjamin R. Umiker
Publikováno v:
Innate Immunity
Crohn’s disease (CD) is a chronic disorder of the gastrointestinal tract characterized by inflammation and intestinal epithelial injury. Loss of function mutations in the intracellular bacterial sensor NOD2 are major risk factors for the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa874f14b54bb52149878cc6fab7643
https://doi.org/10.1177/1753425919826367
https://doi.org/10.1177/1753425919826367