Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Nunzio, Bottini"'
Autor:
John F. Imbery, Celina Wiik, Julia Heinzelbecker, Jenny K. Jebsen, Mia K. Dobbing, Nunzio Bottini, Stephanie M. Stanford, Ludvig A. Munthe, Geir E. Tjønnfjord, Anders Tveita, Peter Szodoray, Britt Nakken
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200841- (2024)
Chronic lymphocytic leukemia (CLL) growth is dependent on both B cell receptor (BCR) signaling and signals from microenvironmental T helper (Th) cells. We previously described a mechanism where Th cells enhance BCR signaling and proliferation through
Externí odkaz:
https://doaj.org/article/dccaffd146a34de9944a3fd659392210
Autor:
David A. McBride, Matthew D. Kerr, Wade T. Johnson, Anders Nguyen, Martina Zoccheddu, Mina Yao, Edward B. Prideaux, Nicholas C. Dorn, Wei Wang, Mattias N.D. Svensson, Nunzio Bottini, Nisarg J. Shah
Publikováno v:
Advanced Science, Vol 10, Iss 11, Pp n/a-n/a (2023)
Abstract Disease modifying antirheumatic drugs (DMARDs) have improved the prognosis of autoimmune inflammatory arthritides but a large fraction of patients display partial or nonresponsiveness to front‐line DMARDs. Here, an immunoregulatory approac
Externí odkaz:
https://doaj.org/article/ba36fd8c266e4995bef236e05e557a36
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 2, Pp n/a-n/a (2022)
Abstract Lipids constitute a diverse class of molecular regulators with ubiquitous physiological roles in sustaining life. These carbon‐rich compounds are primarily sourced from exogenous sources and may be used directly as structural cellular buil
Externí odkaz:
https://doaj.org/article/c465d74ff88b454486e3248f5ccc491c
Autor:
Ruiyuan Zhang, Ganesan Senthil Kumar, Uwe Hansen, Martina Zoccheddu, Cristiano Sacchetti, Zachary J. Holmes, Megan C. Lee, Denise Beckmann, Yutao Wen, Zbigniew Mikulski, Shen Yang, Eugenio Santelli, Rebecca Page, Francesco Boin, Wolfgang Peti, Nunzio Bottini
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Systemic sclerosis (SSc) is a fibrotic autoimmune disease characterized by pathogenic activation of fibroblasts enhanced by local oxidative stress. The tyrosine phosphatase PTP4A1 was identified as a critical promoter of TGF-β signaling in SSc. Oxid
Externí odkaz:
https://doaj.org/article/001f45b2204c49e390f35350bf24c3d6
Autor:
Peter Szodoray, Tor Kristian Andersen, Julia Heinzelbecker, John F. Imbery, Peter C. Huszthy, Stephanie M. Stanford, Bjarne Bogen, Ole B. Landsverk, Nunzio Bottini, Anders Tveita, Ludvig A. Munthe, Britt Nakken
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109525- (2021)
Summary: Humoral immunity relies on the efficient differentiation of memory B cells (MBCs) into antibody-secreting cells (ASCs). T helper (Th) signals upregulate B cell receptor (BCR) signaling by potentiating Src family kinases through increasing CD
Externí odkaz:
https://doaj.org/article/eb782f741c90461f80cc29c4bb22a13b
Autor:
Wan-Chen Hsieh, Mattias N.D. Svensson, Martina Zoccheddu, Michael L. Tremblay, Shimon Sakaguchi, Stephanie M. Stanford, Nunzio Bottini
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Loss-of-function variants of protein tyrosine phosphatase non-receptor type 2 (PTPN2) enhance risk of inflammatory bowel disease and rheumatoid arthritis; however, whether the association between PTPN2 and autoimmune arthritis depends on gut inflamma
Externí odkaz:
https://doaj.org/article/65333424551d4eefb0163c129e129b95
Autor:
Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini, Mitchell Kronenberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to h
Externí odkaz:
https://doaj.org/article/2bd3a4ecc15d4e2986a66ad37a5d8be1
Autor:
Stephanie M. Stanford, Nunzio Bottini
Publikováno v:
Nature Reviews Drug Discovery. 22:273-294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42e88c2dd89df5c21c4e1115524d1279
https://doi.org/10.1038/s41573-022-00618-w
https://doi.org/10.1038/s41573-022-00618-w
Autor:
Cristiano Sacchetti, Yunpeng Bai, Stephanie M. Stanford, Paola Di Benedetto, Paola Cipriani, Eugenio Santelli, Sonsoles Piera-Velazquez, Vladimir Chernitskiy, William B. Kiosses, Arnold Ceponis, Klaus H. Kaestner, Francesco Boin, Sergio A. Jimenez, Roberto Giacomelli, Zhong-Yin Zhang, Nunzio Bottini
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1
Externí odkaz:
https://doaj.org/article/bda2249f57354c398a9b7c97bc41a7fd
Autor:
Brianna Hurysz, Nunzio Bottini
Publikováno v:
Am J Physiol Cell Physiol
Rheumatoid arthritis (RA) is a common autoimmune disease that causes inflammation of the joints and damage to the cartilage and bone. The pathogenesis of RA is characterized in many patients by the presence of antibodies against citrullinated protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834849662ac5ff88f284ee22d4204c0b
https://pubmed.ncbi.nlm.nih.gov/35476502
https://pubmed.ncbi.nlm.nih.gov/35476502