Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Nunziata Maio"'
Autor:
Nunziata Maio
Publikováno v:
Inorganics, Vol 12, Iss 8, p 216 (2024)
Iron–sulfur (Fe-S) clusters are critical to a wide range of biological processes, from DNA repair and transcriptional regulation to mitochondrial respiration and enzymatic catalysis [...]
Externí odkaz:
https://doaj.org/article/42fdf31834d34ce19f0024b6e9f18f25
Autor:
Erika M. Palmieri, Ronald Holewinski, Christopher L. McGinity, Ciro L. Pierri, Nunziata Maio, Jonathan M. Weiss, Vincenzo Tragni, Katrina M. Miranda, Tracey A. Rouault, Thorkell Andresson, David A. Wink, Daniel W. McVicar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase 2 and pyruvate dehydrogenase (PDH) activity. Here, we provide evidence that NO targets the PDH complex by usi
Externí odkaz:
https://doaj.org/article/c6b5815c95e344bdaaa97f1c13a3f7f7
Autor:
Audrey L. Heffner, Nunziata Maio
Publikováno v:
Inorganics, Vol 12, Iss 1, p 34 (2024)
Viruses rely on host cells to replicate their genomes and assemble new viral particles. Thus, they have evolved intricate mechanisms to exploit host factors. Host cells, in turn, have developed strategies to inhibit viruses, resulting in a nuanced in
Externí odkaz:
https://doaj.org/article/31788f8720b24e5dbfab94b8c85ff00c
Autor:
Elodie Mailler, Carlos M. Guardia, Xiaofei Bai, Michal Jarnik, Chad D. Williamson, Yan Li, Nunziata Maio, Andy Golden, Juan S. Bonifacino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
ATG9A is transmembrane autophagic machinery protein that delivers phospholipids to expanding autophagosomes. Mailler et al. show that ATG9A is required to mobilize lipids from lipid droplets for autophagosome expansion as well as mitochondrial fatty
Externí odkaz:
https://doaj.org/article/bc3b482686c54ef6a34fb727e681922d
Autor:
Nunziata Maio, Sara Cherry, David C. Schultz, Brett L. Hurst, W. Marston Linehan, Tracey A. Rouault
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105074- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide outbreak, known as coronavirus disease 2019 (COVID-19). Alongside vaccines, antiviral therapeutics is an important part of the healthcare response to COVID-1
Externí odkaz:
https://doaj.org/article/43d4c990e034466291b40eae203536e4
Autor:
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Kirsten Harvey, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David C Gershlick, Mark R Cookson
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001621 (2022)
[This corrects the article DOI: 10.1371/journal.pbio.3001480.].
Externí odkaz:
https://doaj.org/article/0cfb6188812b44e8a7612e5d6a062027
Autor:
Gang Liu, Debangsu Sil, Nunziata Maio, Wing-Hang Tong, J. Martin Bollinger, Carsten Krebs, Tracey Ann Rouault
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of whic
Externí odkaz:
https://doaj.org/article/e72a170c1c0d4aa795c47a4475b86629
Autor:
Erika M. Palmieri, Marieli Gonzalez-Cotto, Walter A. Baseler, Luke C. Davies, Bart Ghesquière, Nunziata Maio, Christopher M. Rice, Tracey A. Rouault, Teresa Cassel, Richard M. Higashi, Andrew N. Lane, Teresa W.-M. Fan, David A. Wink, Daniel W. McVicar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Production of inflammatory mediators by M1-polarized macrophages is thought to rely on suppression of mitochondrial metabolism in favor of glycolysis. Refining this concept, here the authors define metabolic targets of nitric oxide as responsible for
Externí odkaz:
https://doaj.org/article/1aabd0cb2c6e480fa1e6ac1eb3b1dd56
Autor:
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David C Gershlick, Mark R Cookson
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001480 (2021)
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicity in vitro
Externí odkaz:
https://doaj.org/article/71c689db45394c029f869d5ffc9ae238
Autor:
Christopher M. Rice, Luke C. Davies, Jeff J. Subleski, Nunziata Maio, Marieli Gonzalez-Cotto, Caroline Andrews, Nimit L. Patel, Erika M. Palmieri, Jonathan M. Weiss, Jung-Min Lee, Christina M. Annunziata, Tracey A. Rouault, Scott K. Durum, Daniel W. McVicar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Neutrophils normally fulfil their metabolic demands by glycolysis and have limited mitochondrial activity. Here the authors show that tumours promote neutrophils adapted to oxidative mitochondria metabolism that function in the glucose-restrained tum
Externí odkaz:
https://doaj.org/article/21ee446ffa5a4d17bace3aa38b5d4bbd