Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nuno R, Nené"'
Autor:
Alexander Ney, Nuno R Nené, Eva Sedlak, Pilar Acedo, Oleg Blyuss, Harry J Whitwell, Eithne Costello, Aleksandra Gentry-Maharaj, Norman R Williams, Usha Menon, Giuseppe K Fusai, Alexey Zaikin, Stephen P Pereira
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 8, p e1012408 (2024)
BackgroundThe grim (Methods539 patient serum samples collected under the Accelerated Diagnosis of neuro Endocrine and Pancreatic TumourS (ADEPTS) study (benign disease controls and PDACs) and the UK Collaborative Trial of Ovarian Cancer Screening (UK
Externí odkaz:
https://doaj.org/article/1f19026cd6284ee88a22932d8ae38d4a
Autor:
Nuno R. Nené, Alexander Ney, Tatiana Nazarenko, Oleg Blyuss, Harvey E. Johnston, Harry J. Whitwell, Eva Sedlak, Aleksandra Gentry-Maharaj, Sophia Apostolidou, Eithne Costello, William Greenhalf, Ian Jacobs, Usha Menon, Justin Hsuan, Stephen P. Pereira, Alexey Zaikin, John F. Timms
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
Nené et al. construct machine learning models based on serum protein biomarker data to detect pancreatic ductal adenocarcinoma in a nested case-control study from the UKCTOCS cohort. Their ensemble modelling approach outperforms existing combination
Externí odkaz:
https://doaj.org/article/7cece6036b8243379037823c6a8d4e33
Autor:
Nuno R. Nené, Alexander Ney, Tatiana Nazarenko, Oleg Blyuss, Harvey E. Johnston, Harry J. Whitwell, Eva Sedlak, Aleksandra Gentry-Maharaj, Eithne Costello, William Greenhalf, Ian Jacobs, Usha Menon, Justin Hsuan, Stephen P. Pereira, Alexey Zaikin, John F. Timms
Earlier detection of pancreatic ductal adenocarcinoma (PDAC) is key to improving patient outcomes, as it is mostly detected at advanced stages which are associated with poor survival. Developing non-invasive blood tests for early detection would be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae40de5e0031270bcd48e7ff1b07fb59
https://doi.org/10.1101/2021.12.02.21267187
https://doi.org/10.1101/2021.12.02.21267187
Autor:
Nicoletta Colombo, Daniel Reisel, Andreas Leimbach, David Cibula, Line Bjørge, Martin Widschwendter, Tobias Paprotka, Allison Jones, Michal Zikan, John F. Timms, Dorella Franchi, Nuno R. Nené, Iona Evans, James E. Barrett
Publikováno v:
Clinical Epigenetics
Background The composition of the microbiome plays an important role in human health and disease. Whether there is a direct association between the cervicovaginal microbiome and the host’s epigenome is largely unexplored. Results Here we analyzed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9524497eda783b381ef20996d6598997
https://doi.org/10.1186/s13148-020-00966-7
https://doi.org/10.1186/s13148-020-00966-7
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32779 (2012)
Despite being governed by the principles of nonequilibrium transitions, gene expression dynamics underlying cell fate decision is poorly understood. In particular, the effect of signaling speed on cellular decision making is still unclear. Here we sh
Externí odkaz:
https://doaj.org/article/55d5162be33b440aa58363578426571d
Autor:
Nuno R Nené, Alexey Zaikin
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40085 (2012)
Induction of a specific transcriptional program by external signaling inputs is a crucial aspect of intracellular network functioning. The theoretical concept of coexisting attractors representing particular genetic programs is reasonably adapted to
Externí odkaz:
https://doaj.org/article/b94dec4afe3640c9bc773d8adce90fae
Publikováno v:
Journal of Theoretical Biology
Highlights • We assess the inferrability of a Wright–Fisher drift model from time-resolved genome sequence data. • We identify thresholds at which a Wright–Fisher model can be distinguished from Gaussian diffusion. • Considering a recent ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88b95845cc043fd11e7430353f49fcf
http://europepmc.org/articles/PMC5703635
http://europepmc.org/articles/PMC5703635
Autor:
Martin Widschwendter, Shohreh Ghazali, Susanne Knapp, David Cibula, Andreas Leimbach, Tobias Paprotka, Iona Evans, Dorella Franchi, Nicoletta Colombo, Andy Ryan, Daniel Reisel, Line Bjørge, Nuno R. Nené, Michal Zikan, John F. Timms, Allison Jones
Publikováno v:
The Lancet Oncology
Background: Various factors—including age, family history, inflammation, reproductive factors, and tubal ligation—modulate the risk of ovarian cancer. In this study, our aim was to establish whether women with, or at risk of developing, ovarian c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c254c893ee499960a5473b21cca29a
http://hdl.handle.net/10281/240149
http://hdl.handle.net/10281/240149
Publikováno v:
PLOS Genetics
PLoS Genetics, Vol 14, Iss 10, p e1007718 (2018)
PLoS Genetics
PLoS Genetics, Vol 14, Iss 10, p e1007718 (2018)
PLoS Genetics
Transmission between hosts is a critical part of the viral lifecycle. Recent studies of viral transmission have used genome sequence data to evaluate the number of particles transmitted between hosts, and the role of selection as it operates during t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d85f0327615e1d3065aaaa6085fa591
Publikováno v:
Genetics
A broad range of approaches have considered the challenge of inferring selection from time-resolved genome sequence data. Models describing deterministic changes in allele or haplotype frequency have been highlighted as providing accurate and computa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9011a41e89ede196ceb1c50228ac921
https://pubmed.ncbi.nlm.nih.gov/29500183
https://pubmed.ncbi.nlm.nih.gov/29500183