Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Nuno L. Alves"'
Autor:
Camila Ribeiro, Pedro Ferreirinha, Jonathan J. M. Landry, Fátima Macedo, Laura G. Sousa, Rute Pinto, Vladimir Benes, Nuno L. Alves
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-12 (2024)
Abstract Within the thymus, thymic epithelial cells (TECs) create dedicated microenvironments for T cell development and selection. Considering that TECs are sensitive to distinct pathophysiological conditions, uncovering the molecular elements that
Externí odkaz:
https://doaj.org/article/da79fc1d0d6943c2bccb3c8dd321965f
Autor:
Rute Gonçalves, Joana Couto, Pedro Ferreirinha, José Maria Costa, Diogo Silvério, Marta L. Silva, Ana Isabel Fernandes, Pedro Madureira, Nuno L. Alves, Sofia Lamas, Margarida Saraiva
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105972- (2023)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved to variants associated with milder disease. We employed the k18-hACE2 mouse model to study how differences in the course of infection by SARS-CoV-2 variants alpha, delt
Externí odkaz:
https://doaj.org/article/3d37c31a0cb84333b741b667787563b0
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/b8f43de353754ee79eb6ffd60dac62fa
Autor:
Ruben G. R. Pinheiro, Nuno L. Alves
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The microenvironments formed by cortical (c) and medullary (m) thymic epithelial cells (TECs) play a non-redundant role in the generation of functionally diverse and self-tolerant T cells. The role of TECs during the first weeks of the murine postnat
Externí odkaz:
https://doaj.org/article/953121fe0f19494db4b468f3a159081d
Autor:
Inês Alves, Beatriz Santos-Pereira, Noelia de la Cruz, Ana Campar, Vanda Pinto, Pedro M. Rodrigues, Marco Araújo, Sofia Santos, Javier Ramos-Soriano, Carlos Vasconcelos, Roberto Silva, Nuno Afonso, Filipe Mira, Cristina C. Barrias, Nuno L. Alves, Javier Rojo, Lélita Santos, António Marinho, Salomé S. Pinho
Publikováno v:
Science Translational Medicine. 15
Autoimmune diseases are life-threatening disorders that cause increasing disability over time. Systemic lupus erythematosus (SLE) and other autoimmune diseases arise when immune stimuli override mechanisms of self-tolerance. Accumulating evidence has
Autor:
Pedro M. Rodrigues, Laura G. Sousa, Chiara Perrod, Ana R. Maceiras, Pedro Ferreirinha, Rita Pombinho, Gema Romera-Cárdenas, María Gomez-Lazaro, Meryem Senkara, Jelena Pistolic, Didier Cabanes, Ludger Klein, Paul Saftig, Nuno L. Alves
Publikováno v:
Autophagy.
Within the thymus, thymic epithelial cells (TECs) provide dedicated thymic stroma microenvironments for T cell development. Because TEC functionality is sensitive to aging and cytoablative therapies, unraveling the molecular elements that coordinate
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Publikováno v:
European Journal of Immunology. 50:918-920
Autor:
Mitsuru Matsumoto, Vladimir Benes, Izumi Ohigashi, Leonor Araújo, Jonathan J M Landry, Junko Morimoto, Andrea J. White, Pedro Ferreirinha, Yousuke Takahama, Catarina Meireles, Nuno L. Alves, Minoru Matsumoto, Graham Anderson, Camila Ribeiro
Publikováno v:
European Journal of Immunology
Autoimmune regulator+ (Aire) medullary thymic epithelial cells (mTECs) play a critical role in tolerance induction. Several studies demonstrated that Aire+mTECs differentiate further into Post‐Aire cells. Yet, the identification of terminal stages