Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Nuno J, Machado"'
Autor:
Nuno J. Machado, Ana Paula Ardais, Ana Nunes, Eszter C. Szabó, Vasco Silveirinha, Henrique B. Silva, Manuella P. Kaster, Rodrigo A. Cunha
Publikováno v:
Nutrients, Vol 16, Iss 17, p 2920 (2024)
Coffee intake is increasingly recognized as a life-style factor associated with the preservation of health, but there is still a debate on the relative effects of caffeinated and decaffeinated coffee. We now tested how the regular drinking of caffein
Externí odkaz:
https://doaj.org/article/86210eba164f44fda6a825b3ee93a253
Autor:
Liliana Dias, Cátia R. Lopes, Francisco Q. Gonçalves, Ana Nunes, Daniela Pochmann, Nuno J. Machado, Angelo R. Tomé, Paula Agostinho, Rodrigo A. Cunha
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Depressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P2X7 receptors (P2X7R) and adenosine A2A receptors (A2AR) antagonists attenuate behavioral modifications
Externí odkaz:
https://doaj.org/article/91c658f68075479683e3ae34069f7cb4
Autor:
António C. Silva, Cristina Lemos, Francisco Q. Gonçalves, Anna V. Pliássova, Nuno J. Machado, Henrique B. Silva, Paula M. Canas, Rodrigo A. Cunha, João Pedro Lopes, Paula Agostinho
Publikováno v:
Neurobiology of Disease, Vol 117, Iss , Pp 72-81 (2018)
Alzheimer's disease (AD) begins with a deficit of synaptic function and adenosine A2A receptors (A2AR) are mostly located in synapses controlling synaptic plasticity. The over-activation of adenosine A2A receptors (A2AR) causes memory deficits and th
Externí odkaz:
https://doaj.org/article/7eac53947721403c9a17b334ba8169ed
Autor:
Ana Bruna de Araújo, Francisco Vinícius Clemente Serra Azul, Francisca Raysse Mesquita Silva, Talysson Silva de Almeida, João Victor Nunes Oliveira, Antônia Torres Ávila Pimenta, Antônio Marcos Esmeraldo Bezerra, Nuno J. Machado, Luzia Kalyne Almeida Moreira Leal
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-14
Microglia plays an important role in the neuroinflammatory response, identified as one of the major factors in the development and progression of neurodegenerative diseases. Amburana cearensis and its bioactive compounds, including coumarin (CM), van
Autor:
Douglas T. Leffa, Pablo Pandolfo, Nélio Gonçalves, Nuno J. Machado, Carolina M. de Souza, Joana I. Real, António C. Silva, Henrique B. Silva, Attila Köfalvi, Rodrigo A. Cunha, Samira G. Ferreira
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Adenosine A2A receptors (A2ARs) were recently described to control synaptic plasticity and network activity in the prefrontal cortex (PFC). We now probed the role of these PFC A2AR by evaluating the behavioral performance (locomotor activity, anxiety
Externí odkaz:
https://doaj.org/article/7f828bbc6a6b4a82be3384e5d9ff7c7c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 461 (2021)
The lack of effective disease-modifying therapeutics to tackle Alzheimer’s disease (AD) is unsettling considering the actual prevalence of this devastating neurodegenerative disorder worldwide. Intermittent hypoxic conditioning (IHC) is a powerful
Externí odkaz:
https://doaj.org/article/54ff70994ae84c9bb681f50617f7381b
Autor:
Ana I. Duarte, Emanuel Candeias, Inês N. Alves, Débora Mena, Daniela F. Silva, Nuno J. Machado, Elisa J. Campos, Maria S. Santos, Catarina R. Oliveira, Paula I. Moreira
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1746 (2020)
Alzheimer’s disease (AD) is the most common form of dementia worldwide, being characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the amyloid beta (Aβ) peptide and hyperphosphorylated tau (p-tau), respectively)
Externí odkaz:
https://doaj.org/article/919a4addff9d4c4ca3558df746dc3ef1
Autor:
Marta Regina Santos do Carmo, Amanda Aragão Alves, Geanne Matos de Andrade, Ícaro Gusmão Pinto Vieira, Stephen Rathinara Benjamin, Juliana Fernandes Pereira, Patrícia de Araújo Rodrigues, Selene Maia de Morais, Nuno J. Machado, Albert Layo Costa de Assis
Publikováno v:
Conjecturas. 21:68-86
A doença de Parkinson (DP) é um distúrbio neurológico caracterizado pela destruição neuronal dopaminérgica. Devido à óbvia existência de ácidos graxos poliinsaturados (PUFA) principalmente em sementes de uva, Vitis Vinifera L era mais comu
Autor:
Ana Bruna, de Araújo, Francisco Vinícius Clemente Serra, Azul, Francisca Raysse Mesquita, Silva, Talysson Silva, de Almeida, João Victor Nunes, Oliveira, Antônia Torres Ávila, Pimenta, Antônio Marcos Esmeraldo, Bezerra, Nuno J, Machado, Luzia Kalyne Almeida Moreira, Leal
Publikováno v:
Oxidative medicine and cellular longevity. 2022
Microglia plays an important role in the neuroinflammatory response, identified as one of the major factors in the development and progression of neurodegenerative diseases.
Autor:
Fernanda da Rosa, Nuno J. Machado, Pablo Pandolfo, Cristiane Ribeiro de Carvalho, Carolina Melo de Souza, Lisiane O. Porciúncula, Rodrigo A. Cunha, Douglas Teixeira Leffa, Grasielle C. Kincheski, Diogo O. Souza, Samira G. Ferreira, Reinaldo N. Takahashi
Publikováno v:
European Journal of Neuroscience. 49:1673-1683
Attention deficit and hyperactivity disorder (ADHD) is characterized by impaired levels of hyperactivity, impulsivity, and inattention. Adenosine and endocannabinoid systems tightly interact in the modulation of dopamine signaling, involved in the ne