DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal

Autor: Paola Cattaneo, Michael G. B. Hayes, Nina Baumgarten, Dennis Hecker, Sofia Peruzzo, Galip S. Aslan, Paolo Kunderfranco, Veronica Larcher, Lunfeng Zhang, Riccardo Contu, Gregory Fonseca, Simone Spinozzi, Ju Chen, Gianluigi Condorelli, Stefanie Dimmeler, Marcel H. Schulz, Sven Heinz, Nuno Guimarães-Camboa, Sylvia M. Evans

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

How and whether histone modifications regulate distinct gene networks remains insufficiently understood. Here Cattaneo et al show that DOT1L catalyzed H3K79me2 regulates fetal chamber-specific gene expression and neonatal cardiomyocyte cell cycle wit

Externí odkaz: https://doaj.org/article/af78efbb43a14df4a0071f5cb6653928

Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate.

Autor: C Chase Bolt, Soumya Negi, Nuno Guimarães-Camboa, Huimin Zhang, Joseph M Troy, Xiaochen Lu, Andreas Kispert, Sylvia M Evans, Lisa Stubbs

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0154413 (2016)

The T-box transcription factor TBX18 is essential to mesenchymal cell differentiation in several tissues and Tbx18 loss-of-function results in dramatic organ malformations and perinatal lethality. Here we demonstrate for the first time that Tbx18 is

Externí odkaz: https://doaj.org/article/f6ba77bcb90240929d6c94aa02deef55

The epigenetic modifier DOT1L regulates gene regulatory networks necessary for cardiac patterning and cardiomyocyte cell cycle withdrawal

Autor: Paola Cattaneo, Michael G. B. Hayes, Nina Baumgarten, Dennis Hecker, Sofia Peruzzo, Paolo Kunderfranco, Veronica Larcher, Lunfeng Zhang, Riccardo Contu, Gregory Fonseca, Simone Spinozzi, Ju Chen, Gianluigi Condorelli, Marcel H Schulz, Sven Heinz, Nuno Guimarães-Camboa, Sylvia M. Evans

Mechanisms by which specific histone modifications regulate distinct gene regulatory networks remain little understood. We investigated how H3K79me2, a modification catalyzed by DOT1L and previously considered a general transcriptional activation mar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7814856d49dce2c16706950430d256fe
https://doi.org/10.1101/2022.10.18.512679

Myocardial matrix hydrogel acts as a reactive oxygen species scavenger and supports a proliferative microenvironment for cardiomyocytes

Autor: Raymond M. Wang, Joshua M. Mesfin, Jervaughn Hunter, Paola Cattaneo, Nuno Guimarães-Camboa, Rebecca L. Braden, Colin Luo, Ryan C. Hill, Monika Dzieciatkowska, Kirk C. Hansen, Sylvia Evans, Karen L. Christman

Publikováno v: Acta biomaterialia. 152

As the native regenerative potential of adult cardiac tissue is limited post-injury, stimulating endogenous repair mechanisms in the mammalian myocardium is a potential goal of regenerative medicine therapeutics. Injection of myocardial matrix hydrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5baad045c059b270a68ffa6735b03694
https://pubmed.ncbi.nlm.nih.gov/36041648

Luma is not essential for murine cardiac development and function

Autor: Kirk L. Peterson, Yusu Gu, Xi Fang, Matthew J. Stroud, William H. Bradford, Larry Gerace, Nuno Guimarães-Camboa, Sylvia M. Evans, Nancy D. Dalton, Ju Chen, Jianlin Zhang, Jennifer Veevers

Publikováno v: Stroud, M J, Fang, X, Zhang, J, Guimaraes-Camboa, N, Veevers, J, Dalton, N D, Gu, Y, Bradford, W H, Peterson, K L, Evans, S M, Gerace, L & Chen, J 2018, ' Luma is not essential for murine cardiac development and function ', Cardiovascular Research, vol. 114, no. 3, pp. 378-388 . https://doi.org/10.1093/cvr/cvx205

AimsLuma is a recently discovered, evolutionarily conserved protein expressed in mammalian heart, which is associated with the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex. The LINC complex structurally integrates the nucleus and the cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d20eebd07ad7e81236802d474f827b
https://doi.org/10.1093/cvr/cvx205