MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells

Autor: Rita B. Soares, Rita Manguinhas, João G. Costa, Nuno Saraiva, Nuno Gil, Rafael Rosell, Sérgio P. Camões, Ines Batinic-Haberle, Ivan Spasojevic, Matilde Castro, Joana P. Miranda, Filipa Amaro, Joana Pinto, Ana S. Fernandes, Paula Guedes de Pinho, Nuno G. Oliveira

Publikováno v: Antioxidants, Vol 11, Iss 11, p 2198 (2022)

The manganese(III) porphyrin MnTnHex-2-PyP5+ (MnTnHex) is a potent superoxide dismutase mimic and modulator of redox-based transcriptional activity that has been studied in the context of different human disease models, including cancer. Nevertheless

Externí odkaz: https://doaj.org/article/67a72876692d4ab0aff01917ce527f4b

A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies

Autor: Ana S. Serras, Joana S. Rodrigues, Madalena Cipriano, Armanda V. Rodrigues, Nuno G. Oliveira, Joana P. Miranda

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

The poor predictability of human liver toxicity is still causing high attrition rates of drug candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing authorization stages. This is in part caused by animal models th

Externí odkaz: https://doaj.org/article/5c2ae96c668549b1be074ca02a296405

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Autor: Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Ademowo, Catarina B. Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes, Mutay Aslan, Markus M. Bachschmid, Rui M. Barbosa, Vsevolod Belousov, Carsten Berndt, David Bernlohr, Esther Bertrán, Alberto Bindoli, Serge P. Bottari, Paula M. Brito, Guia Carrara, Ana I. Casas, Afroditi Chatzi, Niki Chondrogianni, Marcus Conrad, Marcus S. Cooke, João G. Costa, Antonio Cuadrado, Pham My-Chan Dang, Barbara De Smet, Bilge Debelec–Butuner, Irundika H.K. Dias, Joe Dan Dunn, Amanda J. Edson, Mariam El Assar, Jamel El-Benna, Péter Ferdinandy, Ana S. Fernandes, Kari E. Fladmark, Ulrich Förstermann, Rashid Giniatullin, Zoltán Giricz, Anikó Görbe, Helen Griffiths, Vaclav Hampl, Alina Hanf, Jan Herget, Pablo Hernansanz-Agustín, Melanie Hillion, Jingjing Huang, Serap Ilikay, Pidder Jansen-Dürr, Vincent Jaquet, Jaap A. Joles, Balaraman Kalyanaraman, Danylo Kaminskyy, Mahsa Karbaschi, Marina Kleanthous, Lars-Oliver Klotz, Bato Korac, Kemal Sami Korkmaz, Rafal Koziel, Damir Kračun, Karl-Heinz Krause, Vladimír Křen, Thomas Krieg, João Laranjinha, Antigone Lazou, Huige Li, Antonio Martínez-Ruiz, Reiko Matsui, Gethin J. McBean, Stuart P. Meredith, Joris Messens, Verónica Miguel, Yuliya Mikhed, Irina Milisav, Lidija Milković, Antonio Miranda-Vizuete, Miloš Mojović, María Monsalve, Pierre-Alexis Mouthuy, John Mulvey, Thomas Münzel, Vladimir Muzykantov, Isabel T.N. Nguyen, Matthias Oelze, Nuno G. Oliveira, Carlos M. Palmeira, Nikoletta Papaevgeniou, Aleksandra Pavićević, Brandán Pedre, Fabienne Peyrot, Marios Phylactides, Gratiela G. Pircalabioru, Andrew R. Pitt, Henrik E. Poulsen, Ignacio Prieto, Maria Pia Rigobello, Natalia Robledinos-Antón, Leocadio Rodríguez-Mañas, Anabela P. Rolo, Francis Rousset, Tatjana Ruskovska, Nuno Saraiva, Shlomo Sasson, Katrin Schröder, Khrystyna Semen, Tamara Seredenina, Anastasia Shakirzyanova, Geoffrey L. Smith, Thierry Soldati, Bebiana C. Sousa, Corinne M. Spickett, Ana Stancic, Marie José Stasia, Holger Steinbrenner, Višnja Stepanić, Sebastian Steven, Kostas Tokatlidis, Erkan Tuncay, Belma Turan, Fulvio Ursini, Jan Vacek, Olga Vajnerova, Kateřina Valentová, Frank Van Breusegem, Lokman Varisli, Elizabeth A. Veal, A. Suha Yalçın, Olha Yelisyeyeva, Neven Žarković, Martina Zatloukalová, Jacek Zielonka, Rhian M. Touyz, Andreas Papapetropoulos, Tilman Grune, Santiago Lamas, Harald H.H.W. Schmidt, Fabio Di Lisa, Andreas Daiber

Publikováno v: Redox Biology, Vol 13, Iss C, Pp 94-162 (2017)

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated t

Externí odkaz: https://doaj.org/article/637c0e34ca5240b4924d5b20463b39fc

MnTnHex-2-PyP

Autor: Rita B, Soares, Rita, Manguinhas, João G, Costa, Nuno, Saraiva, Nuno, Gil, Rafael, Rosell, Sérgio P, Camões, Ines, Batinic-Haberle, Ivan, Spasojevic, Matilde, Castro, Joana P, Miranda, Filipa, Amaro, Joana, Pinto, Ana S, Fernandes, Paula, Guedes de Pinho, Nuno G, Oliveira

Publikováno v: Antioxidants (Basel, Switzerland). 11(11)

The manganese(III) porphyrin MnTnHex-2-PyP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d167f3b6f2d2e6d09c95545202710515
https://pubmed.ncbi.nlm.nih.gov/36358570

[15]aneN4S: Synthesis, Thermodynamic Studies and Potential Applications in Chelation Therapy

Autor: Nuno Torres, Sandrina Gonçalves, Ana S. Fernandes, J. Franco Machado, Maria J. Villa de Brito, Nuno G. Oliveira, Matilde Castro, Judite Costa, Maria F. Cabral

Publikováno v: Molecules, Vol 19, Iss 1, Pp 550-567 (2014)

The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3. The prot

Externí odkaz: https://doaj.org/article/992cc1b9ab644357a50ed48c31da2fd8