Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nuno Charro"'
Autor:
Lia Domingues, David W. Holden, Ahmad Ismail, Luís Jaime Mota, Nuno Charro, Víctor J. Cid, Isabel Rodríguez-Escudero, María Molina
Publikováno v:
Cellular Microbiology. 18:949-969
Many bacterial pathogens use specialized secretion systems to deliver virulence effector proteins into eukaryotic host cells. The function of these effectors depends on their localization within infected cells, but the mechanisms determining subcellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae39418d343c71003bc06ab5ee308f8
https://doi.org/10.1111/cmi.12558
https://doi.org/10.1111/cmi.12558
Autor:
Nuno Charro, Luís Jaime Mota
Publikováno v:
Expert Opinion on Drug Discovery. 10:373-387
The type III secretion system (T3SS) injectisome is an essential virulence mechanism used by many bacterial pathogens to inject host cells with effector proteins. Bacteria harboring T3SSs can cause significant disease in humans. As bacterial antibiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1764d0fda5cb93296dccf1cce80ec9
https://doi.org/10.1517/17460441.2015.1019860
https://doi.org/10.1517/17460441.2015.1019860
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1615
The identification of effector proteins delivered into mammalian host cells by bacterial pathogens possessing syringelike nanomachines is an important step toward understanding the mechanisms underlying the virulence of these pathogens. In this chapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65050789d04f2e3468d0e0a5028d41ee
https://pubmed.ncbi.nlm.nih.gov/28667633
https://pubmed.ncbi.nlm.nih.gov/28667633
Publikováno v:
Methods in Molecular Biology ISBN: 9781493970315
The identification of effector proteins delivered into mammalian host cells by bacterial pathogens possessing syringelike nanomachines is an important step toward understanding the mechanisms underlying the virulence of these pathogens. In this chapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::190cd60b1559df0b8863b1ad6593f6ff
https://doi.org/10.1007/978-1-4939-7033-9_35
https://doi.org/10.1007/978-1-4939-7033-9_35
Autor:
Josip Blonder, DaRue A. Prieto, Haleem J. Issaq, King C. Chan, Nuno Charro, Pilar Azevedo, Deborah Penque, Timothy D. Veenstra, Bruno M. Alexandre, Carlos M. Lopes, António Almeida
Publikováno v:
Journal of Proteomics. 76:259-269
Structural and metabolic alterations in erythrocytes play an important role in the pathophysiology of Chronic Obstructive Pulmonary Disease (COPD). Whether these dysfunctions are related to the modulation of erythrocyte membrane proteins in patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0868bbd173abe7846f20380d5a7469c7
https://doi.org/10.1016/j.jprot.2012.04.008
https://doi.org/10.1016/j.jprot.2012.04.008
Autor:
Francisco M. Couto, Daniel Faria, Josip Blonder, Nuno Charro, King C. Chan, Haleem J. Isaaq, Timothy J. Waybright, Deborah Penque, Timothy D. Veenstra, Tânia Simões
Publikováno v:
Journal of Proteomics
A comprehensive proteomic profiling of nasal epithelium (NE) is described. This study relies on simple subcellular fractionation used to obtain soluble- and membrane-enriched fractions followed by 2-dimensional liquid chromatography (2D-LC) separatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4861c1827c94bf29df6e6901c4a1cc11
http://europepmc.org/articles/PMC7185466
http://europepmc.org/articles/PMC7185466
Autor:
Carlos M. Lopes, António Almeida, Deborah Penque, Paula Pacheco, Francisco M. Couto, Brian L. Hood, Pilar Azevedo, Thomas P. Conrads, Daniel Faria, Nuno Charro
Publikováno v:
Journal of Proteomics. 74:110-126
Complementary 2D-PAGE and ‘shotgun’ LC–MS/MS approaches were combined to identify medium and low-abundant proteins in sera of Cystic Fibrosis (CF) patients (mild or severe pulmonary disease) in comparison with healthy CF-carrier and non-CF carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b7ff5483300b824ba2a6f87ad77cb4
https://doi.org/10.1016/j.jprot.2010.10.001
https://doi.org/10.1016/j.jprot.2010.10.001
Autor:
Thomas P. Conrads, Melanie S. Flint, Mai Sun, Dorothea Becker, Jelena Grahovac, Nuno Charro, Brian L. Hood, Alan Wells
Publikováno v:
Journal of Proteome Research. 9:3656-3663
Gaining insights into the molecular events that govern the progression from melanoma in situ to advanced melanoma, and understanding how the local microenvironment at the melanoma site influences this progression, are two clinically pivotal aspects t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e2b9447d4e30aca4f32f03a21e845f
https://doi.org/10.1021/pr100164x
https://doi.org/10.1021/pr100164x
Autor:
Mark K. Titulaer, Ruvalic M. Buijs-Offerman, Martina Wilke, Jamil Aarbiou, Bob J. Scholte, Thomas Schettgen, Thomas Kraus, Theo M. Luider, Nuno Charro, Deborah Penque, Peter Burgers, Isabel Carvalho-Oliveira
Publikováno v:
Journal of Proteome Research, 8(7), 3606-3616. American Chemical Society
Combined results from laser capture microdissection of mouse airway epithelial cells followed by high power (MALDI-FTICR) MS, and fluorescent two-dimensional gel elctrophoresis (2D-DIGE) of the whole lung, allowed us to identify proteins differential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba9149838616519341fd6ece31c2591
https://hdl.handle.net/1765/32558
https://hdl.handle.net/1765/32558
Autor:
M. H. Florêncio, Lurdes Mira, M J Rodríguez-Gómez, Nuno Charro, Gonçalo C. Justino, Marta R. Santos
Publikováno v:
British Journal of Pharmacology. 153:1750-1761
Background and purpose Flavonoids are known to possess a broad set of pharmacological effects, some of which have been attributed to their antioxidant properties and, more recently, to cell signalling modulation. Nevertheless, flavonoids are extensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1305d67b385ca45fb70e82ec5f63ad9c
https://doi.org/10.1038/bjp.2008.46
https://doi.org/10.1038/bjp.2008.46