Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Nuno Bernardes"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Burkholderia cenocepacia is known for its capacity of adherence and interaction with the host, causing severe opportunistic lung infections in cystic fibrosis patients. In this work we produced Giant Plasma Membrane Vesicles (GPMVs) from a b
Externí odkaz:
https://doaj.org/article/d200559a02f64d75a6e8f60d2573552e
Autor:
Miguel de Almeida Fuzeta, Pedro P. Gonçalves, Ana Fernandes-Platzgummer, Joaquim M. S. Cabral, Nuno Bernardes, Cláudia L. da Silva
Publikováno v:
Bioengineering, Vol 9, Iss 11, p 675 (2022)
Extracellular vesicles (EVs) have been the focus of great attention over the last decade, considering their promising application as next-generation therapeutics. EVs have emerged as relevant mediators of intercellular communication, being associated
Externí odkaz:
https://doaj.org/article/f4f5e9cc1a8b4ab2bbb2290d3e721239
Autor:
Luís Borges-Araújo, Marina E. Monteiro, Dalila Mil-Homens, Nuno Bernardes, Maria J. Sarmento, Ana Coutinho, Manuel Prieto, Fábio Fernandes
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 912 (2022)
Despite its low abundance, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a key modulator of membrane-associated signaling events in eukaryotic cells. Temporal and spatial regulation of PI(4,5)P2 concentration can achieve localized increases in
Externí odkaz:
https://doaj.org/article/4a6a6ad87713480db90ac9bb71e2b748
Autor:
Miguel de Almeida Fuzeta, Nuno Bernardes, Filipa D. Oliveira, Ana Catarina Costa, Ana Fernandes-Platzgummer, José Paulo Farinha, Carlos A. V. Rodrigues, Sunghoon Jung, Rong-Jeng Tseng, William Milligan, Brian Lee, Miguel A. R. B. Castanho, Diana Gaspar, Joaquim M. S. Cabral, Cláudia Lobato da Silva
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mesenchymal stromal cells (MSC) hold great promise for tissue engineering and cell-based therapies due to their multilineage differentiation potential and intrinsic immunomodulatory and trophic activities. Over the past years, increasing evidence has
Externí odkaz:
https://doaj.org/article/b500df7c63514a22843cbaa239e4e991
Autor:
Marília Silva, Gabriel Amaro Monteiro, Arsenio M. Fialho, Nuno Bernardes, Cláudia Lobato da Silva
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Recently, cell-based therapies have been explored as a strategy to enhance the specificity of anticancer therapeutic agents. In this perspective, human mesenchymal stromal cells (MSC) hold a promising future as cell delivery systems for anticancer pr
Externí odkaz:
https://doaj.org/article/8438a5c8ddb44c5595bc0e331720c28f
Autor:
Maria J. Sarmento, Luís Borges-Araújo, Sandra N. Pinto, Nuno Bernardes, Joana C. Ricardo, Ana Coutinho, Manuel Prieto, Fábio Fernandes
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11727 (2021)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is an essential plasma membrane component involved in several cellular functions, including membrane trafficking and cytoskeleton organization. This function multiplicity is partially achieved through
Externí odkaz:
https://doaj.org/article/2e18d906e1f346aa964b02c4c62d8240
Autor:
Ana Rita Garizo, Lígia F. Coelho, Sandra Pinto, Tiago P. Dias, Fábio Fernandes, Nuno Bernardes, Arsénio M. Fialho
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1194 (2021)
Peptides have been thoroughly studied as new therapeutic strategies for cancer treatment. In this work, we explored in vitro the anticancer potential of three novel peptides derived from the C-terminal of azurin, an anticancer bacterial protein produ
Externí odkaz:
https://doaj.org/article/5e6b9e96f44145ab9b0e84785cccbb15
Autor:
Ken Peeters, Frederik Van Leemputte, Baptiste Fischer, Beatriz M. Bonini, Hector Quezada, Maksym Tsytlonok, Dorien Haesen, Ward Vanthienen, Nuno Bernardes, Carmen Bravo Gonzalez-Blas, Veerle Janssens, Peter Tompa, Wim Versées, Johan M. Thevelein
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Yeast and cancer cells both favor sugar fermentation in aerobic conditions. Here the authors describe a conserved mechanism from yeast to mammals where the glycolysis intermediate fructose-1,6-bisphosphate binds Cdc25/Sos1 and couples increased glyco
Externí odkaz:
https://doaj.org/article/d62a394b1ae143ca9a071cacf8de2008
Autor:
Maria J Fradinho, Luísa Mateus, Nuno Bernardes, Rui J B Bessa, Rui M Caldeira, Graça Ferreira-Dias
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219900 (2019)
Development of a healthy musculoskeletal system is of high concern for horse breeders and users. A longitudinal field study was performed in order to: (i) evaluate growth patterns and long-term changes on bone quality, bone metabolism, growth factors
Externí odkaz:
https://doaj.org/article/2794608adfaa4765a135ac73820c1713
Publikováno v:
AIMS Microbiology, Vol 2, Iss 3, Pp 292-303 (2016)
Bacterial proteins and their derivative peptides have emerged as promising anticancer agents. Nowadays they represent a valuable set of candidate drugs with different origins and modes of action. Among these, monomeric cupredoxins, which are metallop
Externí odkaz:
https://doaj.org/article/6897aaf74d3b413da06aff5f7363d0ac