Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Nuno, Saraiva"'
Autor:
Arthur L Schneider, Rita Martins-Silva, Alexandre Kaizeler, Nuno Saraiva-Agostinho, Nuno L Barbosa-Morais
Publikováno v:
eLife, Vol 12 (2024)
We herein introduce voyAGEr, an online graphical interface to explore age-related gene expression alterations in 49 human tissues. voyAGEr offers a visualisation and statistical toolkit for the finding and functional exploration of sex- and tissue-sp
Externí odkaz:
https://doaj.org/article/32eb1b606c78440d8c495371487c8402
Autor:
Renee Salz, Nuno Saraiva-Agostinho, Emil Vorsteveld, Caspar I. van der Made, Simone Kersten, Merel Stemerdink, Jamie Allen, Pieter-Jan Volders, Sarah E. Hunt, Alexander Hoischen, Peter A.C. ’t Hoen
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Our incomplete knowledge of the human transcriptome impairs the detection of disease-causing variants, in particular if they affect transcripts only expressed under certain conditions. These transcripts are often lacking from reference trans
Externí odkaz:
https://doaj.org/article/d83c41876dc44e49a10f480b2d46d03a
Publikováno v:
Biology, Vol 13, Iss 1, p 1 (2023)
Although the discovery of the Golgi apparatus (GA) was made over 125 years ago, only a very limited number of therapeutic approaches have been developed to target this complex organelle. The GA serves as a modification and transport center for protei
Externí odkaz:
https://doaj.org/article/77402a24c8024c3ca40cbfd4f6838bdf
Autor:
Ana F. Raimundo, Sofia Ferreira, Vânia Pobre, Mafalda Lopes-da-Silva, José A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Cláudia N. dos Santos, Regina Menezes
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
IntroductionDiabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, the aggregation and deposition of Islet Amyloid Polypeptide (IAPP), or amylin, is a recognized histopathological marker of the disease.
Externí odkaz:
https://doaj.org/article/a547e5291eb2421b9237abf1524f1d42
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
LOX (Lysyl oxidase) and LOX like 1–4 (LOXL1–4) are amine oxidases that catalyse the cross-linking of elastin and collagen in the extracellular matrix (ECM). This activity can facilitate cell migration and the formation of metastases. Consequently
Externí odkaz:
https://doaj.org/article/f2c800a2a5eb49d1a998f9420686f449
Autor:
João Vieira, Jéssica Castelo, Marta Martins, Nuno Saraiva, Catarina Rosado, Catarina Pereira-Leite
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1209 (2023)
Transfersomes have been highlighted as an interesting nanotechnology-based approach to facilitate the skin delivery of bioactive compounds. Nevertheless, the properties of these nanosystems still need to be improved to enable knowledge transfer to th
Externí odkaz:
https://doaj.org/article/3b58a48fd7994601a35edc0fafd65736
Autor:
Rita B. Soares, Rita Manguinhas, João G. Costa, Nuno Saraiva, Nuno Gil, Rafael Rosell, Sérgio P. Camões, Ines Batinic-Haberle, Ivan Spasojevic, Matilde Castro, Joana P. Miranda, Filipa Amaro, Joana Pinto, Ana S. Fernandes, Paula Guedes de Pinho, Nuno G. Oliveira
Publikováno v:
Antioxidants, Vol 11, Iss 11, p 2198 (2022)
The manganese(III) porphyrin MnTnHex-2-PyP5+ (MnTnHex) is a potent superoxide dismutase mimic and modulator of redox-based transcriptional activity that has been studied in the context of different human disease models, including cancer. Nevertheless
Externí odkaz:
https://doaj.org/article/67a72876692d4ab0aff01917ce527f4b
Autor:
Ana Flórido, Nuno Saraiva, Sara Cerqueira, Nuno Almeida, Maddy Parsons, Ines Batinic-Haberle, Joana P. Miranda, João G. Costa, Guia Carrara, Matilde Castro, Nuno G. Oliveira, Ana S. Fernandes
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 367-378 (2019)
Manganese(III) porphyrins (MnPs) are superoxide dismutase (SOD) mimics with demonstrated beneficial effects in cancer treatment in combination with chemo- and radiotherapy regimens. Despite the ongoing clinical trials, little is known about the effec
Externí odkaz:
https://doaj.org/article/2187bc21422b4a2db5e3ceee7004d36e
Autor:
Nuno Almeida, Guia Carrara, Carlos M. Palmeira, Ana S. Fernandes, Maddy Parsons, Geoffrey L. Smith, Nuno Saraiva
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
The mechanisms by which the Golgi apparatus (GA) impacts on cell invasion are poorly understood. The human Golgi Anti-Apoptotic Protein (hGAAP, also known as TMBIM4) is a highly conserved Golgi cation channel that modulates intracellular Ca2+ fluxes.
Externí odkaz:
https://doaj.org/article/32f74a117a254011bb945414498ae063