Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nungavaram S. Ramamurthy"'
Autor:
Barry L. Gruber, Tuula Salo, Timo Sorsa, Darius Sorbi, Nungavaram S. Ramamurthy, Lorne M. Golub, Hsi-Ming Lee, Yrjö T. Konttinen, Sebastian G. Ciancio
Publikováno v:
Journal of Clinical Periodontology. 22:100-109
We previously reported that low-dose doxycycline (DOXY) therapy reduces host-derived collagenase activity in gingival tissue of adult periodontitis (AP) patients. However, it was not clear whether this in vivo effect was direct or indirect. In the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df559280778fe2ec793dd0039cd1753
https://doi.org/10.1111/j.1600-051x.1995.tb00120.x
https://doi.org/10.1111/j.1600-051x.1995.tb00120.x
Publikováno v:
Journal of Periodontology. 76:229-233
Periodontal disease (PD) and rheumatoid arthritis (RA) share many common pathophysiologic features, but a clinical relationship between the two conditions remains controversial, in part because of the confounding effects of anti-inflammatory drug the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2da43137f450a940eb548379962791
https://doi.org/10.1902/jop.2005.76.2.229
https://doi.org/10.1902/jop.2005.76.2.229
Autor:
Maria Emanuel Ryan, Olli Teronen, Barry R. Rifkin, Analeyda Llavaneras, Pia Heikkilä, Timo Sorsa, Nungavaram S. Ramamurthy, Lorne M. Golub, Tuula Salo
Publikováno v:
Journal of Periodontology. 72:1069-1077
Chemically modified non-antimicrobial tetracyclines (CMTs) have been shown to inhibit pathologically elevated collagenase (and other matrix metalloproteinase, MMP) activity and bone resorption in vivo and in vitro.In the current study, suboptimal dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518095abf090bff5aad1762cb56b652d
https://doi.org/10.1902/jop.2001.72.8.1069
https://doi.org/10.1902/jop.2001.72.8.1069
Publikováno v:
Biochemical Pharmacology. 53:1901-1907
Sulfasalazine is widely used in rheumatoid arthritis and inflammatory bowel diseases. The mechanisms of its activity have not been elucidated. In leukocytes, sulfasalazine and its analogue, CL 42A, inhibited the formation of leukotrienes and possibly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d964874cb4db8251258ce22798da2af5
https://doi.org/10.1016/s0006-2952(97)00137-8
https://doi.org/10.1016/s0006-2952(97)00137-8
Autor:
Lars Kjeldsen, Olli Teronen, Anthony T. Vernillo, Jarkko Hietanen, Niels Borregaard, Tuula Salo, Barry R. Rifkin, Nungavaram S. Ramamurthy, Yrjö T. Konttinen, Timo Sorsa
Publikováno v:
Journal of Oral Pathology and Medicine. 24:78-84
The molecular mechanisms of jaw cyst expansion probably involve interactions of matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs). In this study, molecular species of gelatinases present in neutral salt extracts of cyst walls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7127ae5209fc7d7302678afb169caa7e
https://doi.org/10.1111/j.1600-0714.1995.tb01143.x
https://doi.org/10.1111/j.1600-0714.1995.tb01143.x
Publikováno v:
Calcified Tissue International. 50:411-419
Streptozotocin-induced, insulin-deficient diabetic rats were administrated either minocycline (MC) or a chemically modified non-antimicrobial tetracycline (CMT) by oral gavage for a 3-week period; untreated diabetic and nondiabetic rats served as con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14de617b56b4b0a5ca8e208cd1eceae6
https://doi.org/10.1007/bf00296771
https://doi.org/10.1007/bf00296771
Publikováno v:
The Anatomical Record. 227:427-436
Diabetes induces osteopenia, which is characterized by a deficiency of osteoid and decreased activity of osteoblasts. We recently found that tetracyclines prevent the loss of osteoid and bone matrix and the degeneration of osteoblasts in diabetic rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d8927f54263d4f7546553e8df32078
https://doi.org/10.1002/ar.1092270406
https://doi.org/10.1002/ar.1092270406
Autor:
Ranjev Bhogal, Bob Watson, Jing Wen Xu, Ruth Wills, Mark S. Wolff, Robert A. Greenwald, Nungavaram S. Ramamurthy, Andrew Douglas Baxter, John Bird, David A. Owen
Publikováno v:
Journal of periodontal research. 37(1)
Periodontal disease is characterized by excessive host collagenase resulting in loss of gingival and periodontal ligament collagen and adjacent alveolar bone. Intragingival endotoxin injection induces a model of periodontal disease characterized by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e19d30bbf9a3730565a25b5f0ed8ea3
https://pubmed.ncbi.nlm.nih.gov/11842933
https://pubmed.ncbi.nlm.nih.gov/11842933
Autor:
Kimmo Suomalainen, Hsi-Ming Lee, Y. T. Konttinen, Nungavaram S. Ramamurthy, Veli-Jukka Uitto, Timo Sorsa, Herkko Saari, L M Golub
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:227-229
The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f74a79c5c11ba573a17acc3c5d74ea
https://doi.org/10.1128/aac.36.1.227
https://doi.org/10.1128/aac.36.1.227
Autor:
Barry R. Rifkin, Nungavaram S. Ramamurthy, Robert A. Greenwald, Anthony T. Vernillo, Hsi-Ming Lee, Timo Sorsa, Lorne M. Golub
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 8(10)
Recent studies have demonstrated that tetracyclines (TCs) scavenge reactive oxygen species (ROS). Hypochlorous acid (HOCl), an ROS produced by neutrophils, has been shown to activate neutrophil procollagenase. The objective of the present study was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4803220612e17a22e07a0f5d4431b8e9
https://pubmed.ncbi.nlm.nih.gov/8256662
https://pubmed.ncbi.nlm.nih.gov/8256662